Amyloid-β
β-amyloid peptide; Aβ; Abeta
Amyloid-β (Aβ) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of theamyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is being cut by certain enzymes to yield Aβ. Amyloid-β molecules can aggregate to form flexible soluble oligomers which may exist in several forms. Amyloid-β peptide is due to overproduction of Aβ and/or the failure of clearance mechanisms. Amyloid-β self-aggregates into oligomers, which can be of various sizes, and forms diffuse and neuritic plaques in the parenchyma and blood vessels. Amyloid-β oligomers and plaques are potent synaptotoxins, block proteasome function, inhibit mitochondrial activity, alter intracellular Ca2+levels and stimulate inflammatory processes. Loss of the normal physiological functions of Aβ is also thought to contribute to neuronal dysfunction.
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Amyloid-β Inhibitors
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Amyloid-β Agonists
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Amyloid-β Antagonists
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Amyloid-β Activators
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Amyloid-β Modulators
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Amyloid-β Chemicals
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Amyloid-β Inducers
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Amyloid-β Degraders
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Amyloid-β Controls
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Amyloid-β Substrate
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Amyloid-β Ligands
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Amyloid-β Related Products (761)
Related Products (761)
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Antibodies (9)
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TAK-070 Free base
0 ImagesCat. No.: HY-114234ACAS No.: 212571-56-7TAK-070 Free base is a noncompetitive and orally active BACE1 inhibitor (IC50: 3.15 μM). TAK-070 Free base can be used for research of Alzheimer’s disease (AD). TAK-070 Free base inhibits brain levels of soluble Aβ, and improves cognitive impairments in AD model.
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RS-0406
0 ImagesCat. No.: HY-114884CAS No.: 530112-00-6RS-0406 is a beta-sheet breaker targeting Amyloid-β. RS-0406 can inhibits Aβ(1-42) fibrillogenesis and protect against Aβ(1-42)-induced cytotoxicity in primary hippocampal neurons. RS-0406 can be used for the research of neurological disease, such as Alzheimer's disease (AD).
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β Amyloid (1-39)
0 ImagesCat. No.: HY-P4868CAS No.: 115427-62-8β Amyloid (1-39) is aAβ Fragment.
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4-(6-Bromo-2-benzothiazolyl)benzenamine
0 ImagesCat. No.: HY-111514CAS No.: 566169-97-94-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome.
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BChE-IN-8
0 ImagesCat. No.: HY-147859CAS No.: 2653349-78-9BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research.
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AChE/MAO-B-IN-9
0 ImagesCat. No.: HY-181861CAS No.: 2341935-88-2AChE/MAO-B-IN-9 (Compound E12) is an orally active, selective, reversible, non-competitive AChE and MAO-B inhibitor, with an IC50 of 0.156 μM against electric eel AChE. AChE/MAO-B-IN-9 inhibits Aβ40/42 fibril formation, promotes Aβ fibril depolymerization, and inhibits Tau protein fibril formation. AChE/MAO-B-IN-9 exerts antioxidant and neuroprotective effects, and improves scopolamine (HY-N0296)-induced memory impairment in mice. AChE/MAO-B-IN-9 can be used for the research of Alzheimer's disease.
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PTPA-QM
0 ImagesCat. No.: HY-D3430PTPA-QM is a low-cytotoxicity Aβ protein probe that can be used for live-cell imaging and tissue section staining (Lys. Ex/Em = 385/615 nm). PTPA-QM can intercalate into the β-sheet layered structure of β-amyloid fibrils, form intermolecular interactions with amino acid residues, restrict intramolecular rotation and trigger fluorescence activation for imaging purposes. PTPA-QM is applicable to Alzheimer's disease-related research. Maximum excitation/emission wavelength: 448/605 nm.
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AChE-IN-88
0 ImagesCat. No.: HY-176439CAS No.: 2758789-03-4AChE-IN-88 (Compound 26) is a novel pyridazine derivative. AChE-IN-88 is an orally active multi-target ligand for Alzheimer's disease (AD) that inhibits both acetylcholinesterase (AChE) and amyloid β protein (Aβ) aggregation (pIC50: 7.16).
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BuChE-IN-2
0 ImagesCat. No.: HY-143413CAS No.: 2745118-93-6BuChE-IN-2 is an excellent butyrylcholinesterase (BuChE) inhibitor (IC50s of 1.28 μM and 0.67 μM for BuChE and NO). BuChE-IN-2 can inhibit the aggregation of Aβ, ROS formation and chelate Cu2+, exhibiting proper blood-brain barrier (BBB) penetration. BuChE-IN-2 has potential to research Alzheimer’s disease.
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AF710B
0 ImagesCat. No.: HY-116586AF710B is an orally effective allosteric agonist for the M1 muscarinic receptor and σ1 receptor. AF710B activates the downstream phosphorylated ERK1/2 and phosphorylated CREB signaling pathways. AF710B simultaneously improves cognitive function and alleviates the core pathological features of Alzheimer's disease, including Aβ deposition, excessive Tau phosphorylation and neuroinflammation. AF710B is applicable to the research of Alzheimer's disease.
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Benzenesulphonamide (Standard)
0 ImagesBenzenesulphonamide (Standard) is the analytical standard of Benzenesulphonamide (HY-101087). This product is intended for research and analytical applications. Benzenesulphonamide (Compound 1) is a carbonic anhydrase inhibitor. Benzenesulphonamide exhibits CA II inhibitory activity. Benzenesulphonamide reduces ROS and improves the gene expression of amyloid-β40 and 42. Benzenesulphonamide is beneficial for Alzheimer's disease. Benzenesulphonamide derivatives have anticancer, anti-inflammatory, and anticonvulsant activities. Benzenesulphonamide can be used in the research of Alzheimer's disease, epilepsy, inflammatory diseases, leukemia, melanoma, lung cancer, and colon cancer.
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(Pyr3)-Amyloid β-Protein (3-42)
0 ImagesCat. No.: HY-P4882CAS No.: 183449-57-2(Pyr3)-Amyloid β-Protein (3-42) is an N-terminally truncated pyroglutamylated β-amyloid peptide. (Pyr3)-Amyloid β-Protein (3-42) forms stable β-sheet structures across different pH values, co-oligomerizes with Aβ1-42 to form cytotoxic oligomers, induces tau-dependent cytotoxicity and neuronal loss, inhibits hippocampal LTP, and exhibits stronger protease resistance. (Pyr3)-Amyloid β-Protein (3-42) exists in the brain tissues of human Alzheimer's disease patients, correlates with the pathogenesis of Alzheimer's disease, and follows a unique, faster oligomerization pathway. (Pyr3)-Amyloid β-Protein (3-42) can be used in Alzheimer's disease-related research.
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PMN310
0 ImagesCat. No.: HY-P991535PMN310 is a monoclonal antibody targeting amyloid-β oligomers (AβO). PMN310 prevents AβO-induced memory loss and reduces synaptic loss and inflammation in vivo. PMN310 is potentially useful in Alzheimer's disease research.
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AChE/BChE-IN-32
0 ImagesCat. No.: HY-179711AChE/BChE-IN-32 (Compound 4a) is an AChE and BChE inhibitor, with Ki values of 2.48 and 0.696 μM respectively. AChE/BChE-IN-32 inhibits Aβ aggregation and exhibits a strong ABTS•+ scavenging ability (TEAC = 2.40). AChE/BChE-IN-32 shows significant neuroprotective activity in glutamate and hydrogen peroxide-induced oxidative stress models. AChE/BChE-IN-32 can be used for the study of Alzheimer's disease.
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Spinosin (Standard)
0 ImagesCat. No.: HY-N0651RCAS No.: 72063-39-9Spinosin (Standard) is the analytical standard of Spinosin. This product is intended for research and analytical applications. Spinosyn is a kind of effective C-saccharide, which has a protective effect. Spinosyn is active through Nrf2/HO-1 pathway inhibition Aβ1-42's production and combination.
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γ-Secretase modulator 12
0 ImagesCat. No.: HY-146151CAS No.: 2204249-82-9γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice.
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LY-2434074
0 ImagesCat. No.: HY-10143CAS No.: 883446-27-3LY-2434074 is a selective β-secretase (BACE) inhibitor with an IC50 <100 nM. LY-2434074 can inhibit amyloid-β (Aβ40 and Aβ42) production. LY-2434074 can be used for the research of neurological disease, such as Alzheimer's disease.
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BTA-2
0 ImagesCat. No.: HY-W176465CAS No.: 10205-62-6BTA-2, a benzothiazole dye, is structurally similar to thioflavin T (ThT), which exhibits an enhanced fluorescence signal when bound to amyloid fibrils. BTA-2 has distinct absorption and emission characteristics in solution and when bound to amyloid fibrils, which makes it can used for identifying amyloid fibrils using spectroscopy.
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TPI-1917-49
0 ImagesCat. No.: HY-118972CAS No.: 1250849-11-6TPI-1917-49 is an agent that can cross the blood-brain barrier and reduce amyloid β (Aβ). TPI-1917-49 reduces the production of Aβ peptide segments by promoting the non-amyloidogenic pathway of amyloid precursor protein (APP) (increasing the generation of sAPPα mediated by α-secretase). TPI-1917-49 reduces amyloid plaques in mouse models. TPI-1917-49 can be used in Alzheimer's disease research.
