Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
All Product Categories
-
Calcium Channel Inhibitors
(599)
View all products
-
Calcium Channel Agonists
(35)
View all products
-
Calcium Channel Antagonists
(211)
View all products
-
Calcium Channel Activators
(98)
View all products
-
Calcium Channel Modulators
(46)
View all products
-
Calcium Channel Chemical
(1)
View all products
-
Calcium Channel Inducers
(13)
View all products
-
Calcium Channel Controls
(10)
View all products
-
Calcium Channel Ligands
(7)
View all products
-
Calcium Channel Related Products (1258)
Related Products (1258)
-
Antibodies (29)
-
Related Compound Screening Libraries (1)
-
Calcium Channel Isoform Comparison
-
DPP8/9-IN-2
0 ImagesCat. No.: HY-175226CAS No.: 3109603-86-0DPP8/9-IN-2 (Compound 21) is a DPP8/9 inhibitor with IC50 values of 0.22 nM and 3 nM, respectively, and Ki values of 2.9 nM and 6 nM, respectively . DPP8/9-IN-2 has certain cardiotoxicity, with IC50 values of 0.7 μM, 29.0 μM and 27.7 μM for hERG potassium channel, Nav1.5 sodium channel and Cav1.2 calcium channel, respectively. DPP8/9-IN-2 can be used in the research of diseases such as tumors.
-
Cicletanine
0 ImagesCat. No.: HY-183907CAS No.: 89943-82-8Cicletanine is a voltage-dependent Ca2+ channel inhibitor. Cicletanine inhibits α-adrenoceptor-mediated Ca2+ release pathway, and shows vasodilatory effects on isolated vascular smooth muscle. Cicletanine directly stimulates lysosomal and cytoplasmic cholesteryl ester hydrolase activity. Cicletanine can be used for the research of hypertension.
-
TTA-P2 (Standard)
0 ImagesCat. No.: HY-10035RCAS No.: 1072018-68-8Synonyms: T-Type calcium channel inhibitor (Standard)TTA-P2 (Standard) is the analytical standard of TTA-P2 (HY-10035). This product is intended for research and analytical applications. TTA-P2 (T-Type calcium channel inhibitor) is a selective, orally active, and BBB-penetrant T-type calcium channel blocker (IC50 = 22 nM). TTA-P2 reduces mechanical hypersensitivity and alleviates acute as well as chronic pain. TTA-P2 significantly reduces firing rates in temporal lobe epilepsy (TLE) neurons to control levels and suppresses synaptically evoked burst firing. TTA-P2 can be studied in research for neurological diseases such as tremor and absence epilepsy< sup>.
-
Norverapamil
0 ImagesCat. No.: HY-135328CAS No.: 67018-85-3Synonyms: (±)-Norverapamil; D591Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
-
Rhod-FF tripotassium
0 ImagesCat. No.: HY-172627CAS No.: 945462-68-0Rhod-FF tripotassium is a Rhod-2 derivative and cell-impermeant calcium indicator (Kd of 320 μM). Rhod-FF tripotassium indicates calcium concentration by fluorescence upon binding to calcium ions, with excitation at 552 nm and emission at 580 nm.
-
Monatepil
0 ImagesCat. No.: HY-106818CAS No.: 103377-41-9Synonyms: AJ-2615 free baseMonatepil (AJ-2615 free base) is a calcium antagonist with potent α1-adrenoceptor blocking activity. Monatepil inhibits vasopressin- or methacholine-induced ischemic electrocardiographic changes in a rat model of vasospastic angina and reduces the mean arterial pressure in anesthetized rats. Monatepil also enhances low-density lipoprotein (LDL) receptor activity in human skin fibroblasts. Monatepil can be used in research related to hypertension, atherosclerosis, hyperlipidemia and vasospastic angina.
-
Calcium Channel antagonist 5
0 ImagesCat. No.: HY-W037193CAS No.: 21829-09-4Calcium Channel antagonist 5 (compound 32) is a calcium channel antagonist with a pIC50 of 5.50.
-
RyR2 stabilizer-1
0 ImagesCat. No.: HY-149779CAS No.: 3012675-16-7RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias.
-
15-Methoxypinusolidic acid
0 ImagesCat. No.: HY-N1593CAS No.: 769928-72-515-Methoxypinusolidic acid (compound 1) is a labdane diterpene compound isolated from the leaves of Calocedrus microlepic.
-
Calcium channel-modulator-1
0 ImagesCalcium channel-modulator-1 is an orally active calcium channel modulator that blocks aortic contraction with an IC50 of 0.8 μM. Calcium channel-modulator-1 can be used for the study of cardiovascular conditions.
-
β-Amino Acid Imagabalin Hydrochloride
0 ImagesCat. No.: HY-U00250CAS No.: 610300-00-0Synonyms: PD-0332334β-Amino Acid Imagabalin Hydrochloride (PD-0332334) is a ligand for the α2δ subunit of the voltage-dependent calcium channel.
-
Myomodulin
0 ImagesCat. No.: HY-P0268CAS No.: 110570-93-9Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.
-
CP-060
0 ImagesCat. No.: HY-U00354CAS No.: 180090-15-7
-
McN5691
0 ImagesCat. No.: HY-U00218CAS No.: 99254-95-2Synonyms: RWJ26240McN5691 is a voltage-sensitive calcium channel blocker.
-
α2δ ligand 1
0 ImagesCat. No.: HY-U00388CAS No.: 313653-15-5α2δ ligand 1 is a ligand to the α2δ-1 subunit of voltage-sensitive calcium channel, extracted from patent US20040186177.
-
Dopropidil
0 ImagesCat. No.: HY-U00151CAS No.: 79700-61-1Dopropidil is a novel anti-anginal calcium ion modulating agent, possessing intracellular calcium antagonist activity and anti-ischemic effects in several predictive animal models.
-
Darodipine
0 ImagesCat. No.: HY-U00086CAS No.: 72803-02-2Synonyms: PY 108-068; PY-108068Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.
-
AE0047 Hydrochloride
0 ImagesCat. No.: HY-U00284CAS No.: 116308-56-6AE0047 Hydrochloride is a calcium blocker, used in the research of hypertensive disease.
