Collagen
Collagen
Collagens are the most abundant proteins in mammals. The collagen family comprises 28 members that contain at least one triple-helical domain. Beyond the existence of 28 collagen types, further diversity occurs in the collagen family because of the existence of several molecular isoforms for the same collagen type (e.g., collagens IV and VI) and of hybrid isoforms comprised of a chains belonging to two different collagen types (type V/XI molecules). Collagens are deposited in the extracellular matrix where most of them form supramolecular assemblies. Four collagens are type II membrane proteins that also exist in a soluble form released from the cell surface by shedding. Collagens play structural roles and contribute to mechanical properties, organization, and shape of tissues. They interact with cells via several receptor families and regulate their proliferation, migration, and differentiation[1].
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Collagen Related Products (93)
Related Products (93)
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Clofezone
0 ImagesCat. No.: HY-127150CAS No.: 17449-96-6Synonyms: PerclusoneClofezone (Perclusone) is an antirheumatic agent that inhibits collagen formation in rat Chondrus granulomas. Clofezone can be used in the study of various rheumatic diseases, especially arthritis (RA) and ankylosing spondylitis (AS).
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Salviamarinic acid A
0 ImagesCat. No.: HY-N17650CAS No.: 3038746-92-5Salviamarinic acid A is a water-soluble phenolic acid that can be extracted from Salvia miltiorrhiza with potent anti-pulmonary fibrosis activity. Salviamarinic acid A significantly increases cell viability, cell index, cell motility and E-cadherin expression, and reduces TGF-β1, α-SMA and Collagen I levels. Salviamarinic acid A can be used for pulmonary fibrosis research.
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Oxoglaucine
0 ImagesOxoglaucine (O-Methylatheroline) is a natural product with multiple activities including autophagy activation, anti-inflammation, antibacterial activity, and immunoregulation. Oxoglaucine inhibits the TRPV5/calmodulin/CAMK-II pathway, suppresses TGFβ-induced Smad2 phosphorylation by upregulating Smad7, blocks Ca2+ influx, activates autophagy, alleviates apoptosis and inflammation, inhibits ROS production and the expression of fibrosis markers in hepatocytes, and regulates immune cell populations and responses. Oxoglaucine protects against infections caused by Candida albicans and Klebsiella pneumoniae, and exerts effects on adjuvant-induced arthritis. Oxoglaucine can be used in studies related to arthritis, liver fibrosis, bacterial infections, and fungal infections.
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Methyl cholate (Standard)
0 ImagesMethyl cholate (Standard) is the analytical standard of Methyl cholate. This product is intended for research and analytical applications. Methyl cholate is a bile acid analog and a specific inhibitor of TcdB toxin from Clostridioides difficile. Methyl cholate exerts a stronger selective inhibitory effect on TcdB than on TcdA. Methyl cholate induces conformational stabilization by binding to a unique site of TcdB, thereby blocking the binding of the toxin to host receptors and its self-processing process. Methyl cholate effectively protects human fibroblasts from TcdB-induced cytopathic effects. Methyl cholate exhibits dose-dependent anti-hepatic fibrosis activity in both cellular and zebrafish models, and significantly reduces the expression levels of α-SMA and COL-I. Methyl cholate is suitable for in-depth research in the fields of Clostridioides difficile infection and hepatic fibrosis.
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Myristoyl pentapeptide-4
0 ImagesMyristoyl pentapeptide-4 is a bioactive peptide with promotion of hair growth effect and has been reported used as a cosmetic ingredient.
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Endotrophin (Mus musculus) TFA
0 ImagesCat. No.: HY-P5081AEndotrophin (Mus musculus) TFA is an adipokine, a cleavage fragment derived from Collagen VI, whose levels are elevated in adipose tissue and breast tumors of obese mice. Endotrophin (Mus musculus) TFA activates the TGF-β signaling pathway and reduces the expression of hormone-sensitive lipase. Endotrophin (Mus musculus) TFA induces adipogenesis, lipid accumulation, fibrosis, inflammation, angiogenesis, adipose tissue expansion, epithelial-mesenchymal transition, and insulin resistance; it also induces Cisplatin (HY-17394) resistance in cancer cells. Endotrophin (Mus musculus) TFA can be used in research related to metabolic diseases such as obesity and type 2 diabetes, as well as cancers such as breast cancer.
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Cyclo(Ala-Hyp)
0 ImagesCat. No.: HY-P11626CAS No.: 67943-21-9Cyclo(Ala-Hyp) is an orally effective collagen-derived hydroxyproline-containing cyclic dipeptide that can be isolated from the culture supernatant of Lactobacillus plantarum. Cyclo(Ala-Hyp) has an AUC0-6h of 2.350 μg/mL·h, significantly higher than traditional collagen oligopeptides. Cyclo(Ala-Hyp) can be used in research related to liver and kidney function protection, skin care, and joint health.
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Endotrophin (Mus musculus)
0 ImagesCat. No.: HY-P5081CAS No.: 1678414-54-4Endotrophin (Mus musculus) is an adipokine, a cleavage fragment derived from Collagen VI, whose levels are elevated in adipose tissue and breast tumors of obese mice. Endotrophin (Mus musculus) activates the TGF-β signaling pathway and reduces the expression of hormone-sensitive lipase. Endotrophin (Mus musculus) induces adipogenesis, lipid accumulation, fibrosis, inflammation, angiogenesis, adipose tissue expansion, epithelial-mesenchymal transition, and insulin resistance; it also induces Cisplatin (HY-17394) resistance in cancer cells. Endotrophin (Mus musculus) can be used in research related to metabolic diseases such as obesity and type 2 diabetes, as well as cancers such as breast cancer.
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Ac-Phospho-L-arginine
0 ImagesCat. No.: HY-175571Ac-Phospho-L-arginine is a ClpC ligand. Ac-Phospho-L-arginine can be used to synthesize BacPROTAC-1 (HY-153575). BacPROTAC-1 is a BacPROTAC degrader that induces the degradation of the target protein mSA by recruiting ClpC/ClpC1.
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GPVGPS
0 ImagesCat. No.: HY-P11890CAS No.: 1154403-54-9GPVGPS is a low-molecular-weight fish collagen peptide. GPVGPS upregulates the expression of vascular endothelial growth factor (VEGF), PCNA, hepatocyte growth factor, epidermal growth factor (EGF) , and insulin-like growth factor 1 (IGF-1), and downregulates the expression of negative regulatory proteins associated with hair health. GPVGPS inhibits MMP-1, MMP-2, and MMP-9, increases skin water content, reduces wrinkles, and improves oxidative stress status and pro-inflammatory cytokine levels. GPVGPS can be used in studies related to hair loss and UVB-induced skin photoaging.
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Antifibrotic agent 3
0 ImagesCat. No.: HY-184738CAS No.: 2103516-38-5Antifibrotic agent 3 is an orally active antifibrotic agent. Antifibrotic agent 3 reduces hepatic stellate cell activation by downregulating the expression of Collagen I and α-SMA. Antifibrotic agent 3 inhibits liver fibrosis in bile duct ligation and carbon tetrachloride-induced liver fibrosis models. Antifibrotic agent 3 can be used for the research of liver fibrosis.
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JNK3-IN-11
0 ImagesCat. No.: HY-181993JNK3-IN-11 is a selective JNK3 inhibitor with an IC50 of 2.08 nM. JNK3-IN-11 binds to the JNK3 ATP-binding pocket, forming conserved hydrogen bonds with Met149 and a water-mediated hydrogen bond with Lys93. JNK3-IN-11 suppresses TGF-β1-induced c-Jun phosphorylation, reduces profibrotic markers COL1A1 and PAI-1, restores E-cadherin expression, and has protection against podocyte injure. JNK3-IN-11 can be used for the research of chronic kidney disease.
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Phosphodiesterase-IN-5
0 ImagesCat. No.: HY-179645Phosphodiesterase-IN-5 is a potent, orally active and selective phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 6.2 nM. Phosphodiesterase-IN-5 shows >1612-fold selectivity over other PDEs. Phosphodiesterase-IN-5 exhibits potent antifibrotic efficacy in a Bleomycin (BLM) (HY-108345)-induced murine model of pulmonary fibrosis (PF) by blocking myofibroblast differentiation via the cAMP/PKA/CREB signaling pathway. Phosphodiesterase-IN-5 can be used for the research of PF.
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Laricitrin 3-rutinoside
0 ImagesCat. No.: HY-N7984CAS No.: 55481-90-8Synonyms: Laricitrin 3-O-rutinosideLaricitrin 3-rutinoside (Laricitrin 3-O-rutinoside) is a flavonol rutin. Laricitrin 3-rutinoside can be isolated from the fruits of Ginkgo biloba. Laricitrin 3-rutinoside inhibits ERK phosphorylation, reactive oxygen species (ROS) production, and matrix metalloproteinase-1 (MMP-1) secretion. Laricitrin 3-rutinoside inhibits Collagen degradation. Laricitrin 3-rutinoside reduces the secretion of proinflammatory cytokines interleukin 6 (IL-6) and interleukin 8 (IL-8). Laricitrin 3-rutinoside is applicable to research related to skin aging.
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HSF1/AMPK activator 1
0 ImagesCat. No.: HY-181808CAS No.: 2170935-59-6HSF1/AMPK activator 1 is a compound that modulates the HSF1/AMPK axis and the TGF-β1/Smad signaling pathway. HSF1/AMPK activator 1 exhibits anti-hepatic fibrosis activity and metabolic stability. HSF1/AMPK activator 1 inhibits fibrosis formation and cell proliferation in activated hepatic stellate cells. HSF1/AMPK activator 1 alleviates liver injury and hepatic fibrosis symptoms in fibrotic mice. HSF1/AMPK activator 1 is applicable to research related to hepatic fibrosis.
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GV-001
0 ImagesCat. No.: HY-182904CAS No.: 3082707-76-1GV-001 is a selective and orally active HDAC6 inhibitor with an IC50 of 1.18 nM against HDAC6. GV-001 selectively enhances α-tubulin acetylation, reduces sIL-6 and Collagen I levels, suppresses renal cyst growth, and upregulates PC1 expression. GV-001 can be used for the study of autosomal dominant polycystic kidney disease (ADPKD).
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Rebimastat
0 ImagesCat. No.: HY-14239CAS No.: 259188-38-0Synonyms: BMS 275291Rebimastat (BMS 275291) is an orally active, broad-spectrum MMP inhibitor and non-peptide collagen mimetic. Rebimastat has some selectivity because it does not inhibit all MMP activities. Rebimastat can be used in the research of colorectal cancer.
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AB-004
0 ImagesCat. No.: HY-P992166Synonyms: ADCE-D01 AntibodyAB-004 is a humanized monoclonal antibody and ADC targeting uPARAP. AB-004 can be conjugated with the topoisomerase-1 inhibitor P1021 via a protease-cleavable tetrapeptide linker to form the ADC ADCE-D01. AB-004 binds to tumor cells expressing uPARAP, triggering the endocytosis of the ADC. AB-004 is applicable for cancer research.
