Laricitrin 3-rutinoside
Laricitrin 3-rutinoside (Laricitrin 3-O-rutinoside) is a flavonol rutin. Laricitrin 3-rutinoside can be isolated from the fruits of Ginkgo biloba. Laricitrin 3-rutinoside inhibits ERK phosphorylation, reactive oxygen species (ROS) production, and matrix metalloproteinase-1 (MMP-1) secretion. Laricitrin 3-rutinoside inhibits Collagen degradation. Laricitrin 3-rutinoside reduces the secretion of proinflammatory cytokines interleukin 6 (IL-6) and interleukin 8 (IL-8). Laricitrin 3-rutinoside is applicable to research related to skin aging.
For research use only. We do not sell to patients.
- CAS No.: 55481-90-8
- Formula: C28H32O17
- Molecular Weight:640.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-6 |
IL-8 |
MMP-1 |
Laricitrin 3-rutinoside (25-100 μM; 1 h) potently inhibits TNF-α-induced intracellular ROS generation in normal human dermal fibroblasts, with the strongest effect at 100 μM[1].
Laricitrin 3-rutinoside (25-100 μM; 1 h pre-incubation, 24 h TNF-α treatment) suppresses TNF-α-induced MMP-1 secretion and protects against collagen degradation in normal human dermal fibroblasts, with significant effects observed at 25, 50, and 100 μM[1].
Laricitrin 3-rutinoside (25-100 μM; 1 h pre-incubation, 24 h TNF-α treatment) suppresses TNF-α-induced secretion of pro-inflammatory cytokines IL-6 and IL-8 in normal human dermal fibroblasts, with significant effects observed at concentrations of 25, 50, and 100 μM[1].
Laricitrin 3-rutinoside (25-100 μM; 1 h pre-incubation, 15 min TNF-α treatment) potently inhibits TNF-α-induced ERK phosphorylation and moderately reduces JNK phosphorylation in normal human dermal fibroblasts at concentrations of 25, 50, and 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TNF-α-stimulated normal human dermal fibroblasts (NHDFs)
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Concentration:25 μM; 50 μM; 100 μM
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Incubation Time:1 h (pre-incubation); 24 h (TNF-α treatment)
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Result:Diminished TNF-α-induced MMP-1 secretion to 13.5 ng/mL relative to the TNF-α-only group at 25 μM (p < 0.001).
Diminished TNF-α-induced MMP-1 secretion to 14.1 ng/mL relative to the TNF-α-only group at 50 μM (p < 0.001).
Diminished TNF-α-induced MMP-1 secretion to 8.80 ng/mL relative to the TNF-α-only group at 100 μM (p < 0.001).
Increased COLIA1 secretion to 12.9 ng/mL relative to the TNF-α-only group at 100 μM (p < 0.01).\nReduced TNF-α-induced IL-6 secretion to 5.88 ng/mL relative to the TNF-α-only group at 50 μM (p < 0.05).
Reduced TNF-α-induced IL-6 secretion to 4.32 ng/mL relative to the TNF-α-only group at 100 μM (p < 0.001).
Attenuated TNF-α-induced IL-8 secretion to 4.03 ng/mL relative to the TNF-α-only group at 25 μM (p < 0.001).
Attenuated TNF-α-induced IL-8 secretion to 3.38 ng/mL relative to the TNF-α-only group at 50 μM (p < 0.001).
Attenuated TNF-α-induced IL-8 secretion to 6.23 ng/mL relative to the TNF-α-only group at 100 μM (p < 0.001).
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Cell Line:TNF-α-stimulated normal human dermal fibroblasts (NHDFs)
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Concentration:25 μM; 50 μM; 100 μM
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Incubation Time:1 h (pre-incubation); 15 min (TNF-α treatment)
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Result:Inhibited TNF-α-induced ERK phosphorylation to 0.50-fold relative to the TNF-α-only group at 25 μM (p < 0.001).
Inhibited TNF-α-induced ERK phosphorylation to 0.75-fold relative to the TNF-α-only group at 50 μM (p < 0.001).
Inhibited TNF-α-induced ERK phosphorylation to 0.73-fold relative to the TNF-α-only group at 100 μM (p < 0.001).
Reduced TNF-α-induced JNK phosphorylation to 1.22-fold relative to the TNF-α-only group at 100 μM (p < 0.05).
Exerted no significant effect on p38 phosphorylation.
Chemical Information
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CAS No. 55481-90-8
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Molecular Weight 640.55
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Formula C28H32O17
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SMILES
O(C1=C(OC=2C(C1=O)=C(O)C=C(O)C2)C3=CC(OC)=C(O)C(O)=C3)[C@@H]4O[C@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@H]4O
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Synonyms
Laricitrin 3-O-rutinoside
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Laricitrin 3-rutinoside Related Classifications
HY-N7984 Related Classifications
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