2. Signaling Pathways
  3. GPCR/G Protein
  4. Endothelin Receptor
  5. ETB Isoform
  6. ETB Antagonist

ETB Antagonist

ETB Antagonists (12):

Cat. No. Product Name Effect Purity
  • HY-14184
    Macitentan
    		Antagonist 99.95%
    Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist.
  • HY-120295
    A-192621
    		Antagonist 99.85%
    A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM.
  • HY-B0323
    Sulfisoxazole
    		Antagonist 99.95%
    Sulfisoxazole (Sulfafurazole) is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively.
  • HY-106994A
    Nebentan potassium
    		Antagonist 99.53%
    Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013).
  • HY-103460
    IRL 2500
    		Antagonist ≥99.0%
    IRL 2500 is a potent Endothelin receptor antagonist.
  • HY-15895
    Aprocitentan
    		Antagonist 98.13%
    Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan.
  • HY-106994
    Nebentan
    		Antagonist 99.67%
    Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013).
  • HY-17351
    Tezosentan
    		Antagonist 98.79%
    Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively.
  • HY-19263
    BMS-193884
    		Antagonist
    BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor.
  • HY-B0323A
    Sulfisoxazole diethanolamine
    		Antagonist
    Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively.
  • HY-15895S
    Aprocitentan-d4
    		Antagonist
    Aprocitentan D4 (ACT-132577 D4) is a deuterium labeled Aprocitentan.
  • HY-19431
    Ro 46-8443
    		Antagonist 99.24%
    Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist.