Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
-
Fungal Related Products (2768)
Related Products (2768)
-
Antibodies (1)
-
Related Compound Screening Libraries (1)
-
Cynaroside (Standard)
0 ImagesSynonyms: Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities.
-
Isopyrazam
0 ImagesCat. No.: HY-W774934CAS No.: 881685-58-1Isopyrazam is a plant protection product with fungal activity. Isopyrazam exhibits excellent disease resistance on crops and effectively inhibits the growth of multiple plant pathogenic fungi. The application of Isopyrazam can significantly improve the yield and quality of crops.
-
SDZ285428
0 ImagesSDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h).
-
Polycarpine hydrochloride
0 ImagesPolycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50 = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC50 values of 30.0 nM and 0.12 μM against SARS-CoV-2 Mpro and PEDV Mpro, respectively.
-
Demethoxyencecalin
0 ImagesDemethoxyencecalin is a chromene isolated from Helianthus annuus, has antifungal activities.
-
Phenazine-1-carboxylic acid (Standard)
0 ImagesPhenazine-1-carboxylic acid (Standard) is the analytical standard of Phenazine-1-carboxylic acid. This product is intended for research and analytical applications. Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation[1][2][3][4].
-
Kakuol
0 ImagesKakuol is a natural compound with antifungal activity.
-
Nerol (Standard)
0 ImagesNerol (Standard) is the analytical standard of Nerol. This product is intended for research and analytical applications. Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity.
-
Bactenecin TFA
0 ImagesCat. No.: HY-P1508APurity: 98.02%Synonyms: Bactenecin, bovine TFABactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei.
-
Sulcatone (Standard)
0 ImagesSynonyms: 6-Methyl-5-hepten-2-one (Standard)Sulcatone (Standard) (6-Methyl-5-hepten-2-one (Standard)) is the analytical standard of Sulcatone (HY-W010435). This product is intended for research and analytical applications. Sulcatone (6-Methyl-5-hepten-2-one) is a plant-derived volatile organic compound with activities such as insecticidal, antifungal, and blood pressure-lowering effects. Sulcatone also serves as an insect pheromone and an endogenous metabolite, which can be found in feces. Changes in Sulcatone levels can be used for the auxiliary diagnosis of ulcerative colitis.
-
Asukamycin
0 ImagesCat. No.: HY-118893CAS No.: 61116-33-4Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines.
-
(S,S)-Valifenalate
0 ImagesSynonyms: (S,S)-IR5885; (S,S)-Valiphenal(S,S)-Valifenalate ((S,S)-IR5885) is an acylamino acid fungicide and is used to control a wide range of fungi belonging to the class of Oomycetes. (S,S)-Valifenalate ((S,S)-IR5885) interferes with the cell-wall synthesis thus affecting the growth stages of the pathogens controlled, both outside (on the spores) or inside the plant (on the mycelium).
-
Mutanocyclin
0 ImagesMutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candida albicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse.
-
(-)-Bornyl acetate
0 Images(-)-Bornyl acetate (L-(-)-Bornyl acetate), isolated from hyssop oil, is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate possesses antifungal activity.
-
Isorhapontin
0 ImagesIsorhapontin is an antifungal agent. Isorhapontin inhibits the hydrolytic activity of Trichoderma cellobiohydrolase I (CBH I) with a Ki of 57.2 μM. Isorhapontin also inhibits the activity of Trichoderma endoglucanase I.
-
Tetramethylkaempferol
0 ImagesTetramethylkaempferol is an antifungal agent. Tetramethylkaempferol shows antifungal activity against Candida albicansCandida albicans with an IC50 value of 17.63 µg/mL.
-
Ergosterol acetate
0 ImagesErgosterol acetate is a natural compound that can be isolated from fungi.
-
Penconazole (Standard)
0 ImagesPenconazole (Standard) is the analytical standard of Penconazole. This product is intended for research and analytical applications. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
-
Polyoxin D
0 ImagesSynonyms: PolyoxorimPolyoxin D (Polyoxorim) is an Antifungal Antibiotic. Polyoxin D inhibits Chitin synthase with an I50 of 1 mM for Stomoxys calcitrans chitin synthase. Polyoxin D causes swelling and rupture of fungal hyphal tips and budding yeast cells, haustorial encasement, haustorial wall thickening, widening of the extrahaustorial matrix, and cytoplasmic vesicles and tubular structures. Polyoxin D causes swelling of filamentous chains in Candida albicans and morphological changes in Agaricus bisporus and Coprinus cinereus. Polyoxin D is used in research on bean rust and Candida albicans infections.
