Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2768)
Related Products (2768)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Hydroxy Itraconazole (Standard)
0 ImagesSynonyms: Itraconazole metabolite Hydroxy Itraconazole (Standard); R-63373 (Standard)Levetiracetam (Standard) is the analytical standard of Levetiracetam. This product is intended for research and analytical applications. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent.
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Cinnamon bark oil, from Cinnamonum zeylanicum Blume
0 ImagesCinnamon bark oil, from Cinnamonum zeylanicum Blume is a antifungal agent against fungi causing respiratory tract mycoses.
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Dermaseptin TFA
0 ImagesDermaseptin TFA, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration.
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3-(Methylthio)propionic acid (Standard)
0 ImagesSynonyms: 3-Methylsulfanylpropionic acid (Standard)3-(Methylthio)propionic acid (Standard) is the analytical standard of 3-(Methylthio)propionic acid. This product is intended for research and analytical applications. 3-(Methylthio)propionic acid is an intermediate in the methionine metabolism.
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Veratrosine
0 ImagesVeratrosine is a Trihydroxynapthalene reductase (THR) inhibitor and fungal plant pathogen inhibitor. Veratrosine interacts with THR, an enzyme in the DHN melanin biosynthesis pathway of Curvularia lunata. Veratrosine can be used for the research of leaf blight of rice, brown spot of rice, and blast disease of foxtail millet.
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Faltan (Standard)
0 ImagesFaltan (Standard) is the analytical standard of Faltan. This product is intended for research and analytical applications. Faltan is a dicarboximide fungicide, widely used on vines and several vegetable crops, and is also cytotoxic effect on human bronchial epithelial cells.
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Methylisothiazolinone hydrochloride
0 ImagesMethylisothiazolinone hydrochloride is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone hydrochloride can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone hydrochloride can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone hydrochloride can cause mitochondrial damage in the endothelium of rat cerebral blood vessels.
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Citronellol (Standard)
0 ImagesCat. No.: HY-W010201RCAS No.: 106-22-9Synonyms: (±)-Citronellol (Standard); (±)-β-Citronellol (Standard)Citronellol (Standard) is the analytical standard of Citronellol. Citronellol (Standard) is an orally active inducer of apoptosis. Citronellol (Standard) can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol (Standard) can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol (Standard) can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol (Standard) exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.
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Bacimethrin
0 ImagesBacimethrin (NSC 66577) is an antibacterial agent and is thiamin biosynthesis antagonist.Bacimethrin inhibits bacterial and yeast growth.
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Diamthazole hydrochloride
0 ImagesSynonyms: Dimazole hydrochlorideDiamthazole (Dimazole) hydrochloride is an antifungal agent. Diamthazole hydrochloride can be used for the research of infection.
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Fenpicoxamid
0 ImagesCat. No.: HY-122298CAS No.: 517875-34-2Synonyms: XDE 777Fenpicoxamid is a new fungicide. Fenpicoxamid inhibits the growth of the fungus Z. tritici with an EC50 value of 0.051 mg/L.
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Defensin HNP-3 human
0 ImagesCat. No.: HY-P2302CAS No.: 136661-76-2Defensin HNP-3 human is an α-defensin stored in the azurophilic granules of human neutrophils. Defensin HNP-3 human exerts broad-spectrum bactericidal, antifungal and antiviral activities mainly by forming bacterial membrane pores, and acts as a chemoattractant for monocytes and T cells. Defensin HNP-3 human maintains epithelial integrity to support periodontal tissue homeostasis, and exerts concentration-dependent effects on epithelial cell proliferation, adhesion and bacterial adhesion. Defensin HNP-3 human targets solid tumors and leukemia by inducing single-strand DNA breaks and membrane permeabilization in tumor cells via electrostatic binding and pore formation. Defensin HNP-3 human is abundant in human tongue squamous cell carcinoma and neutrophils infiltrating oral squamous cell carcinoma. Defensin HNP-3 human can be applied to research related to periodontitis and human tongue squamous cell carcinoma.
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Antifungal agent 1
0 ImagesAntifungal agent 1 is a potent antifungal agent.
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Citronellyl butyrate
0 ImagesCat. No.: HY-W166491CAS No.: 141-16-2Citronellyl butyrate is a terpenoid ester with antibacterial, antifungal and other biological activities. Citronellyl butyrate has inhibitory effects on both Staphylococcus aureus and Escherichia coli. Citronellyl butyrate has inhibitory and bactericidal effects on various strains of Candida albicans (MIC: 156-1250 μg/mL). Citronellyl butyrate can be used in the research of infectious conditions.
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Solasodine (Standard)
0 ImagesSynonyms: Purapuridine (Standard); Solancarpidine (Standard); Solasodin (Standard)Solasodine (Standard) is the analytical standard of Solasodine. This product is intended for research and analytical applications. Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.
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Paclobutrazol-d4
0 ImagesCat. No.: HY-W749242Paclobutrazol-d4 is the deuterium labeled Paclobutrazol. Paclobutrazol is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins.
