Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2768)
Related Products (2768)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Sequosempervirin B
0 ImagesCat. No.: HY-N1289CAS No.: 864719-17-5Sequosempervirin B, a norlignan isolated from the branches and leaves of Sequoia sempervirens, has antifungal properties. Sequosempervirin B has an inhibitory effect on cyclic AMP phosphodiesterase.
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Antifungal agent 39
0 ImagesCat. No.: HY-151423CAS No.: 2725074-94-0Antifungal agent 39 (Compound 9h) is a broad-spectrum antifungal agent.
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Trigonelline chloride (Standard)
0 ImagesTrigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.
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2-Phenylethyl isothiocyanate-d5
0 ImagesCat. No.: HY-23155SCAS No.: 912627-98-6Synonyms: 2-PE ITC-d52-Phenylethyl isothiocyanate-d5 isothiocyanate-d5 is the deuterium labeled 2-Phenylethyl isothiocyanate[1]. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity[2][3].
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Fumonisin B3-13C34-1
0 ImagesCat. No.: HY-N6726S1CAS No.: 1217494-88-6Fumonisin B3-13C34-1 is the isotopic internal standard of Fumonisin B3 (HY-N6726). Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma.
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Pyrimorph
0 ImagesCat. No.: HY-123155CAS No.: 868390-90-3Pyrimorph is a fungicide with excellent antifungal activity against oomycetes.
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Topazolin
0 ImagesCat. No.: HY-133169CAS No.: 109605-79-0Topazolin is a flavone. Topazolin has weak fungi-toxic activity against Cladosporium herbarum AHU 9262.
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Elsinochrome A
0 ImagesCat. No.: HY-N10611CAS No.: 24568-67-0Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm).
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Hydroxyphenyllactic acid-d4
0 ImagesCat. No.: HY-113219SHydroxyphenyllactic acid-d4 is the deuterium labeled Hydroxyphenyllactic acid (HY-113219). Hydroxyphenyllactic acid is an antifungal metabolite.
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ECO-02301
0 ImagesCat. No.: HY-N19232CAS No.: 735316-93-5ECO-02301 is an antifungal agent identified in Streptomyces aizunensis NRRL B-11277. ECO-02301 exhibits antifungal activity against human pathogenic fungi including Candida albicans, and can be used in research related to fungal infections.
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5-(12Z-Heptadecenyl)-resorcinol
0 ImagesCat. No.: HY-N7519CAS No.: 103462-06-25-(12Z-Heptadecenyl)-resorcinol serves as the main component of Antifungal mixtures. 5-(12Z-Heptadecenyl)-resorcinol can be isolated from mango peels. Antifungal mixtures composed of 5-(12Z-Heptadecenyl)-resorcinol exhibit activity against Alternaria alternata. 5-(12Z-Heptadecenyl)-resorcinol can be used in studies related to mango fruit black spot disease.
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Aszonapyrone A
0 ImagesCat. No.: HY-N8258CAS No.: 83103-08-6Aszonapyrone A is a metabolite produced by Aspergillus zonatus.
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Wyerone
0 ImagesCat. No.: HY-N21819CAS No.: 20079-30-5Wyerone is a furan-acetylene phytoalexin that exhibits antifungal activity and selective toxicity against Gram-positive bacteria. Wyerone is abundantly biosynthesized and accumulated in broad bean tissues following infection by Botrytis, and it inhibits the growth of Gram-positive bacteria. Wyerone is applicable to studies related to plant infections.
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Hexetidine (Standard)
0 ImagesHexetidine (Standard) is the analytical standard of Hexetidine. This product is intended for research and analytical applications. Hexetidine is an orally active antiseptic with broad antibacterial and antifungal activity. Hexetidine give important potential for treatment of oral infections.
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(+)-Benalaxyl
0 ImagesCat. No.: HY-124894CAS No.: 97716-85-3(+)-Benalaxyl is a broad-spectrum benzamide fungicide. (+)-Benalaxyl inhibits the growth of the freshwater algae S. obliquus, with an EC50 value of 8.441 mg/L. (+)-Benalaxyl can induce the production of chlorophyll a and b, as well as increase the activity of superoxide dismutase (SOD) and the generation of malondialdehyde (MDA). (+)-Benalaxyl has inhibitory effects on catalase (CAT). (+)-Benalaxyl is effective against diseases caused by oomycetes.
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4-O-Methylsappanol
0 ImagesCat. No.: HY-N2640CAS No.: 104778-16-74-O-Methylsappanol is a natural isoflavonoid with antifungal activities. 4-O-Methylsappanol shows activity against Beauveria bassiana. 4-O-Methylsappanol (EC50 of 4.6 μM) strongly suppresses Melanin (Melanin) synthesis in HMV-II cells.
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Toonaciliatin M
0 ImagesCat. No.: HY-N11079CAS No.: 93930-04-2Toonaciliatin M (compound 6) is a pmaradiene-type diterpenoid that can be isolated from Toona ciliate. Toonaciliatin M show antifungal activity against Trichophyton rubrum with an MIC value of 12.5 µg/mL.
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Gly(Boc)-GGG
0 ImagesCat. No.: HY-187118CAS No.: 174308-47-5Gly (Boc)-GGG is a tetrapeptide that can be used to inhibit bacterial or fungal activity. Gly (Boc)-GGG acts synergistically with Fluconazole (HY-B0101) to inhibit fungal growth. Gly (Boc)-GGG acts synergistically with Erythromycin (HY-B0220) to inhibit bacterial growth. Gly (Boc)-GGG itself has no significant antifungal or antibacterial activity. Gly (Boc)-GGG can be used in the research of bacterial and fungal infections.
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CDA-IN-2
0 ImagesCat. No.: HY-171542CAS No.: 2559404-67-8CDA-IN-2 (Compound VS#2-3) is a chitin deacetylase (Chitin Deacetylase, CDA) inhibitor with antifungal activity. At a concentration of 100 μM, it can inhibit the CDA PxCDA1 and PxCDA2 of P. xanthii by 83.7% and 74.5% respectively. CDA-IN-2 can be applied to the research in the field of controlling agricultural fungal diseases, such as dealing with resistant powdery mildew and Botrytis cinerea .
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Paecilaminol
0 ImagesCat. No.: HY-N10184CAS No.: 540770-33-0Synonyms: FKI-0550Paecilaminol is an amino alcohol and NADH-fumarate reductase inhibitor (IC50 = 5.1 μM against Ascaris suum) that also inhibits both helminth and mammalian mitochondrial complexes I and III, exhibiting antifungal, antibacterial, nematocidal, insecticidal, and cancer cell growth-inhibitory activities. Paecilaminol can be used in research on helminth infections.
