GPR119
G Protein-Coupled Receptor 119
G protein-coupled receptor 119 (GPR119) is a member of the class A (rhodopsin-type) GPCR family, which is highly expressed on only a limited number of tissues, such as pancreatic β-cells and enteroendocrine cells of the gastrointestinal tract in humans. The activation of GPR119 has the stimulatory effects of glucose-dependent insulin secretion in pancreatic β-cells as well as intestinal secretion of incretin hormones including glucose-dependent insulinotropic peptide (GIP) and glucagon-likepeptide1 (GLP-1). Taken together, these effects represented a potential mechanism for modulation of glucose homeostasis and an attractive approach to the treatment of type 2 diabetes mellitus (T2DM). GPR119 can be activated by oleoylethanolamide and several other endogenous lipids containing oleic acid: these include N-oleoyl-dopamine, 1-oleoyl-lysophosphatidylcholine, generated in the tissue, and 2-oleoyl glycerol generated in the gut lumen.
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GPR119 Related Products (40)
Related Products (40)
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AS1907417
0 ImagesCat. No.: HY-126807CAS No.: 885038-66-4AS1907417 is a novel GPR119 agonist with an oral activity. AS1907417 is a modified form of AS1269574. AS1907417 has antihyperglycemic and can be used in the research of type 2 diabetes.
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GSK1104252A
0 ImagesCat. No.: HY-18354CAS No.: 1001397-20-1GSK1104252A is a potent and selective GPR119 agonist. GSK1104252A can be used for type 2 diabetes research.
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DPP-4/GPR119 modulator 2
0 ImagesCat. No.: HY-146469CAS No.: 2010927-65-6DPP-4/GPR119 modulator 2 (Compound 20i) is a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist with an IC50 of 0.22 μM for DPP-IV and an EC50 of 0.95 μM for GPR119. DPP-4/GPR119 modulator 2 can be used for diabetes research. DPP-4/GPR119 modulator 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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MK-8282
0 ImagesCat. No.: HY-124978CAS No.: 1147556-27-1MK-8282 is a potent, orally active GPR-119 agonist. MK-8282 shows improved glucose tolerance. MK-8282 can be used in the research of type 2 diabetes.
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GPR119 agonist 4
0 ImagesCat. No.: HY-182454CAS No.: 1353004-92-8GPR119 agonist 4 is a GPR119 agonist and oral glucose-lowering agent with a human GPR119 EC50 of 42 nM.GPR119 agonist 4 activates GPR119.GPR119 agonist 4 reduces blood glucose area under the curve in an oral glucose tolerance test.GPR119 agonist 4 exhibits improved clearance in liver microsomes.GPR119 agonist 4 can be used for the research of type 2 diabetes mellitus.
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PSN 375963 hydrochloride
0 ImagesCat. No.: HY-108258ACAS No.: 1781834-82-9
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2-Oleoylglycerol-d5
0 ImagesCat. No.: HY-W701772CAS No.: 946524-37-4Synonyms: 2-OG-d52-Oleoylglycerol-d5 (2-OG-d5) is the deuterium labeled 2-Oleoylglycerol (HY-W011121). 2-Oleoylglycerol (2-OG) is a lipid found in the diet. It is a GPR119 agonist, with an EC50 value of 2.5 μM in activating hGPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol enhances the inflammatory response of macrophages and promotes fibrosis by activating the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. It also stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol is expected to be used in the research of non-alcoholic steatohepatitis (NASH) .
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1-Oleoyl lysophosphatidylcholine
0 Images1-Oleoyl lysophosphatidylcholine is a GPR119 activator and insulin secretion potentiator with a human GPR119 EC50 of 1.5 μM.1-Oleoyl lysophosphatidylcholine acts as a bioactive lipid mediator with diverse physiological and pathological functions.1-Oleoyl lysophosphatidylcholine can be used for the research of diabetes.
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GSK2041706A
0 ImagesCat. No.: HY-113653CAS No.: 1032824-43-3Synonyms: GSK706GSK2041706A (GSK706) is a potent G protein-coupled receptor 119 (GPR119) agonist. GSK2041706A can be used for the research of type 2 diabetes.
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GSK-1292263 hydrochloride
0 ImagesCat. No.: HY-12066ACAS No.: 1032824-54-6GSK-1292263 (hydrochloride) is an orally active GPR119 agonist (pEC50 of approximately 6.9 and 6.7 nM for human and rat GPR119, respectively). GSK-1292263 is used in the research of type 2 diabetes and dyslipidemia.
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GPR119 agonist 2
0 ImagesCat. No.: HY-155553CAS No.: 1384951-03-4GPR119 agonist 2 (compound 43) is an orally active GPR119 agonist. GPR119 agonist 2 shows good pharmacokinetic characteristics in rodents and can effectively improve glucose tolerance in mice and rats. GPR119 agonist 2 has the potential to study type 2 diabetes.
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PSN 375963 (Standard)
0 ImagesCat. No.: HY-108258RCAS No.: 388575-52-8PSN 375963 (Standard) is the analytical standard of PSN 375963 (HY-108258). This product is intended for research and analytical applications. PSN 375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 shows similar potency to the endogenous agonist oleoylethanolamide (OEA).
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AS1269574 (Standard)
0 ImagesCat. No.: HY-107535RCAS No.: 330981-72-1AS1269574 (Standard) is the analytical standard of AS1269574 (HY-107535). This product is intended for research and analytical applications. AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes.
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AR 231453 (Standard)
0 ImagesAR 231453 (Standard) is the analytical standard of AR 231453. This product is intended for research and analytical applications. AR 231453 is a potent, specific and orally available GPR119 agonist. AR 231453 can stimulate β-cell replication and improve islet graft function s.
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APD668 (Standard)
0 ImagesAPD668 (Standard) is the analytical standard of APD668. This product is intended for research and analytical applications. APD668 is a potent, selective and orally active agonist of G-protein coupled receptor GPR119, with EC50s of 2.7 nM and 33 nM for hGPR119 and rGPR119, respectively. APD668 shows no significant inhibition of any of the five major CYP isoforms with the exception of CYP2C9 (Ki=0.1 μM). APD668 can be used for the research of steatohepatitis and diabetes.
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AS-1669058 free base
0 ImagesCat. No.: HY-117446ACAS No.: 1395553-31-7AS-1669058 free base is a GPR119 agonist and a potential inhibitor of type 2 diabetes. AS-1669058 free base induces insulin secretion induced by high blood glucose levels in vitro and in vivo and increases insulin promoter activity. In animal studies, AS-1669058 free base improved glucose tolerance and reduced blood glucose levels in db/db mice.
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AS-1669058
0 ImagesCat. No.: HY-117446CAS No.: 1395553-32-8AS-1669058 is a GPR119 agonist and a potential inhibitor of type 2 diabetes. AS-1669058 induces insulin secretion in response to high blood glucose levels in vitro and in vivo and increases insulin promoter activity. In animal studies, AS-1669058 improved glucose tolerance and reduced blood glucose levels in db/db mice.
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Firuglipel (Standard)
0 ImagesCat. No.: HY-109032RCAS No.: 1371591-51-3Synonyms: DS-8500a (Standard)Firuglipel (Standard) is the analytical standard of Firuglipel (HY-109032). This product is intended for research and analytical applications. Firuglipel (DS-8500a) is an orally available, potent and selective GPR119 agonist.
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GSK1292263 (Standard)
0 ImagesGSK1292263 (Standard) is the analytical standard of GSK1292263. This product is intended for research and analytical applications. GSK-1292263 is an orally available GPR119 agonist with pEC50s of 6.9 and 6.7 for human and rat GPR119, respectively. GSK-1292263 can be used for the research of type 2 diabetes mellitus (T2DM).
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