Glycosidase
Glycosidase
Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].
References:
- [1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.
- [2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]
All Product Categories
-
Glycosidase Inhibitors
(456)
View all products
-
Glycosidase Antagonist
(1)
View all products
-
Glycosidase Activators
(20)
View all products
-
Glycosidase Modulators
(8)
View all products
-
Glycosidase Chemical
(1)
View all products
-
Glycosidase Inducers
(2)
View all products
-
Glycosidase Degrader
(1)
View all products
-
Glycosidase Controls
(6)
View all products
-
Glycosidase Substrates
(25)
View all products
-
Glycosidase Ligands
(3)
View all products
-
Glycosidase Related Products (697)
Related Products (697)
-
Antibodies (3)
-
α-Amylase/α-Glucosidase-IN-27
0 ImagesCat. No.: HY-189388α-Amylase/α-Glucosidase-IN-27 is a dual-target inhibitor of α-glucosidase and α-amylase, with IC50 values of 18.12 and 37.85 μM, respectively. α-Amylase/α-Glucosidase-IN-27 inhibits the hydrolysis of internal α-1,4-glycosidic bonds in polysaccharides by α-amylase through acting on the amylase active site. α-Amylase/α-Glucosidase-IN-27 can be used in diabetes-related research.
-
(S)-N-(1H-Indole-3-acetyl)tryptophan-d4
0 ImagesCat. No.: HY-138815S(S)-N-(1H-Indole-3-acetyl)tryptophan-d4 is deuterium labeled (S)-N-(1H-Indole-3-acetyl)tryptophan. (S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase.
-
Dendrocandin U
0 ImagesCat. No.: HY-N21802CAS No.: 1922084-93-2Dendrocandin U is a bibenzyl compound found in Dendrobium officinale that exhibits anti-inflammatory activity and α-glucosidase inhibitory effect (IC50 = 9.46 mM). Dendrocandin U inhibits the expression of TLR4 and MyD88 in the TLR4/MyD88/NF-kB pathway, suppresses the phosphorylation of NF-kB p65 and I-kBα, and blocks the nuclear translocation of NF-kB p65. Dendrocandin U inhibits M1 polarization, NO secretion, and TNF-α release in alveolar macrophages, and reduces inflammatory morphological changes in macrophages. Dendrocandin U promotes neurite outgrowth in PC12 cells. Dendrocandin U can be used for research on inflammation-related diseases and type 2 diabetes.
-
Glyurallin A
0 ImagesCat. No.: HY-N8947CAS No.: 199331-36-7Glyurallin A (Compound 79) is isolated from the naturalGlycyrrhiza uralensis. Glyurallin A inhibitsα-Glucosidase(HY-P2802)(IC50=0.3 μM). Glyurallin A can be used in the study of anti-diabetes.
-
Migalastat-d2 hydrochloride
0 ImagesCat. No.: HY-14929SSynonyms: GR181413A-d2Migalastat-d2 hydrochloride (GR181413A-d2) is the deuterium labeled Migalastat hydrochloride (HY-14929A). Migalastat (GR181413A free base) is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity.
-
Giffonin P
0 ImagesCat. No.: HY-N9821CAS No.: 1830306-93-8Giffonin P is a selective inhibitor targeting α-glucosidase with an IC50 of 55.3 μM. Giffonin P delays carbohydrate hydrolysis and glucose absorption, exerting anti-hyperglycemic activity. Giffonin P reduces postprandial blood glucose levels and is primarily used in research on type 2 diabetes.
-
Sekikaic acid
0 ImagesSekikaic acid is an α-glucosidase (Glucosidase) and α-amylase (Amylases) inhibitor with hypolipidemic, antioxidant and antidiabetic activities. Sekikaic acid significantly reduces LDL, total cholesterol, and total glyceride levels and causes pancreatic beta cell regeneration.
-
Therapeutic agent-1
0 ImagesCat. No.: HY-153592CAS No.: 850020-01-8Therapeutic agent-1 is a heteroaryl compound that can be used in Gaucher disease glucocerebrosidase activity enzyme replacement therapy.
-
α-Glucosidase-IN-99
0 ImagesCat. No.: HY-178742α-Glucosidase-IN-99 (Compound 21) is an α-Glucosidase inhibitor, with an IC50 of 52.79 μM. α-Glucosidase-IN-99 can be used for the study of type 2 diabetes.
-
Kaempferol-3-O-a-L-(3'',4''-di-Z-p-coumaroyl)-rhamnopyranoside
0 ImagesCat. No.: HY-N19683CAS No.: 1067238-40-7Kaempferol-3-O-a-L-(3'',4''-di-Z-p-coumaroyl)-rhamnopyranoside is a 3-O-(coumaroyl-rhamnopyranosyl)-flavonol compound found in the leaf extract of Machilus philippinense Merr..
-
β-Glucosidase, Bacteroides fragilis
0 ImagesCat. No.: HY-P2775Dβ-Glucosidase, Bacteroides fragilis (EC 3.2.1.21), is a glucosidase that acts on the β1→4 glycosidic bond connecting two glucose molecules or glucose-substituted molecules (e.g., disaccharide cellobiose). β-Glucosidase is an exonuclease specific for a variety of β-D-glycosidic substrates. β-Glucosidase catalyzes the hydrolysis of the terminal non-reducing residues of β-D-glucosides, releasing glucose.
-
3,4-Dicaffeoylquinic acid (Standard)
0 ImagesCat. No.: HY-N0057RCAS No.: 14534-61-3Synonyms: 3,4-Di-O-caffeoylquinic acid (Standard); Isochlorogenic acid B (Standard)3,4-Dicaffeoylquinic acid (Standard) is the analytical standard of 3,4-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL.
-
α-Glucosidase-IN-90
0 ImagesCat. No.: HY-174223α-Glucosidase-IN-90 (Compound 7b) is an α-Glucosidase inhibitor (IC50: 14.48 nM). α-Glucosidase-IN-90 binds to HIS:280 and ASN:415 residues of α-glucosidase via hydrogen bonds, inhibiting the activity of the enzyme. α-Glucosidase-IN-90 can be used in the study of diabetes.
-
Chlorophenol red sodium
0 ImagesCat. No.: HY-W331502CAS No.: 123333-64-2Synonyms: 3,3''-Dichlorophenolsulfonphthalein sodiumChlorophenol Red sodium is a sulfonephthalein pH indicator dye and chromogenic beta-galactosidase substrate. Chlorophenol Red sodium enables the detection of coliform bacteria through β-galactosidase activity. Chlorophenol Red sodium can be used in research on drinking water quality monitoring.
-
α-Amylase-IN-12
0 ImagesCat. No.: HY-168495CAS No.: 1799667-33-6α-Amylase-IN-12 (Compound 5e) is an α-amylase inhibitor (IC50: 0.15 mM) with a mixed inhibition. α-Amylase-IN-12 has an IC50 of 9.40 mM against α-glucosidase. α-Amylase-IN-12 promotes glucose uptake in yeast cells and exhibits significant antiglycation activity at high concentrations. α-Amylase-IN-12 can be used for the research of diabetes.
-
Kifunensine (Standard)
0 ImagesSynonyms: FR-900494 (Standard)Bromperidol decanoate (Standard) is the analytical standard of Bromperidol decanoate. This product is intended for research and analytical applications. Bromperidol decanoate (R46541) is a compound used for the inhibition of schizophrenia and has certain clinical inhibitory activity.
-
XAT-13
0 ImagesCat. No.: HY-181891CAS No.: 3107904-58-2XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases.
