Glycosidase
Glycosidase
Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].
References:
- [1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.
- [2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]
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Glycosidase Inhibitors
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Glycosidase Antagonist
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Glycosidase Activators
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Glycosidase Modulators
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Glycosidase Chemical
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Glycosidase Inducers
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Glycosidase Degrader
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Glycosidase Controls
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Glycosidase Substrates
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Glycosidase Ligands
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Glycosidase Related Products (697)
Related Products (697)
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Antibodies (3)
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β-Galactosidase, Sweet almond
0 Imagesβ-Galactosidase, Sweet almond is a glycoside hydrolase that hydrolyzes the β-glycosidic bonds formed between galactose and its organic moieties. β-Galactosidase, Sweet almond can hydrolyze lactose to form glucose and galactose, and enter glycolysis; it can also catalyze the transgalactosylation of lactose into allolactose; allolactose can be cracked into monosaccharides.
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Alpha-1,6-fucosidase C
0 ImagesCat. No.: HY-E70029ASynonyms: AlfCAlpha-1,6-fucosidase C (AlfC) is a GH29 fucosidase that shows specificity to α1,6-linked Fuc48.
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HPA-IN-2
0 ImagesCat. No.: HY-143269CAS No.: 2885971-91-3HPA-IN-2 (Compound 2a-1) is a potent and selective human pancreatic α-amylase (HPA) inhibitor with IC50 values of 8.2 μM and 450.7 μM against HPA and α-glucosidase, respectively.
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Delphinidin-3-O-galactoside chloride (Standard)
0 ImagesCat. No.: HY-N6606RCAS No.: 28500-00-7Delphinidin-3-O-galactoside chloride (Standard) is the analytical standard of Delphinidin-3-O-galactoside chloride (HY-N6606). This product is intended for research and analytical applications. Delphinidin-3-O-galactoside chloride is an anthocyanin found in abbiteye blueberry. Delphinidin-3-O-galactoside chloride show inhibitory activitiesagainst α-glucosidase with an IC50 of 68.33 μM, and tyrosinase with an IC50 of 34.14 μM. Delphinidin-3-O-galactoside chloride attenuates HO-1 and HSP70 messenger RNA down-regulation, suppresses cytotoxicity, reduces endoplasmic reticulum stress responses, scavenges free radicals, reduces intracellular triglyceride levels and lipid droplet accumulation. Delphinidin-3-O-galactoside chloride can be used for the researches of diabesity, melanoma and inflammation.
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α-Glucosidase-IN-47
0 ImagesCat. No.: HY-157489CAS No.: 3029697-33-1α-Glucosidase-IN-47 (compound 8H) is a non-competitive α-glucosidase (α-glucosidase) inhibitor with IC50 value is 38.2 μM and Ki value is 38.2 μM. α-Glucosidase-IN-47 can be used in diabetes research..
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Dichotomine C
0 ImagesCat. No.: HY-N15708CAS No.: 755036-45-4Synonyms: (R)-(-)-Dichotomine CDichotomine C ((R)-(-)-Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of β-hexosaminidase in RBL-2H3 cells with an IC50 of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated TNF-α and IL-4 in RBL-2H3 cells with IC50s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions.
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Licheninase
0 ImagesCat. No.: HY-E70013ACAS No.: 37288-51-0Synonyms: EC 3.2.1.73Licheninase (EC 3.2.1.73) is a glycoside hydrolase that acts on the β-glucan cell walls of cereals, fungal and seaweeds. Licheninase specifically hydrolyzes the β(1→4) linkages in mixed-linkage β(1→3)/β(1→4)-glucans. Licheninase promotes cellulose degradation.
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5-C-phenethyl-DNJ
0 ImagesCat. No.: HY-178202CAS No.: 2734265-58-65-C-phenethyl-DNJ is a selective α-glucosidase GAA inhibitor, with its Ki value for rhGAA being 0.81 μM. 5-C-phenethyl-DNJ exhibits extremely high selectivity for GANAB, GBA1, and GBA2. 5-C-phenethyl-DNJ can be used for the study of Pompe disease.
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Kojibiose (Standard)
0 ImagesCat. No.: HY-113133RCAS No.: 2140-29-6Kojibiose (Standard) is the analytical standard of Kojibiose. This product is intended for research and analytical applications. Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo[1][2].
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Parvisoflavone B
0 ImagesCat. No.: HY-N17601CAS No.: 50277-02-6Parvisoflavone B is a prenylated flavonoid. Parvisoflavone B can be isolated from root bark of Erythrina mildbraedii. Parvisoflavone B inhibits PTP1B activity with an IC50 of 42.6 μM. Parvisoflavone B inhibits α-glucosidase with an IC50 of 12.19 μM. Parvisoflavone B can be used in the research of type 2 diabetes and obesity.
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α-Glucosidase-IN-91
0 ImagesCat. No.: HY-174310α-Glucosidase-IN-91 (Compound 15j) is a competitive and potent inhibitor for α-Glucosidase (IC50 = 6.6 μM). α-Glucosidase-IN-91 has a potent binding affinity towards α-Glucosidase. α-Glucosidase-IN-91 exhibits high stability, interacting and inhibiting α-Glucosidase selectively. α-Glucosidase-IN-91 can be studied in research for type 2 diabetes and blood glucose control.
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Chalcomoracin
0 ImagesCat. No.: HY-N20674CAS No.: 76472-89-4Chalcomoracin is an orally active anticancer agent. Chalcomoracin exhibits anticancer, antibacterial, and α-glucosidase inhibitory activities, with an IC50 of 14.23 µM against yeast α-glucosidase and an IC50 of 5.5 μM against FabI of Staphylococcus aureus. Chalcomoracin reduces the phosphorylation levels of ERK, JNK, and P38; enhances the phosphorylation level of ERK1/2; regulates the MAPK, mTOR, AKT, and p53 signaling pathways; upregulates the expression of Chop, Bip, PINK1, GRP78, and GADD153; and downregulates the expression of Alix. Chalcomoracin induces apoptosis (apoptosis), endoplasmic reticulum stress (endoplasmic reticulum stress), paraptosis (paraptosis), ROS production, mitophagy (mitophagy), and autophagy (autophagy); it inhibits cancer cell viability, colony-forming ability, migration, invasion, proliferation, tumorigenesis, fatty acid synthesis, S. aureus growth, vitreous-stimulated retinal cell activity, and cell cycle progression at the G0/G1 phase. Chalcomoracin can be used in research related to hepatocellular carcinoma, non-small cell lung cancer, triple-negative breast cancer, prostate cancer, proliferative vitreoretinopathy, pancreatic cancer, diabetes, and bacterial infections.
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α-Galactosidase, Clostridium cellulolyticum
0 ImagesCat. No.: HY-P2871Dα-Galactosidase, Clostridium cellulolyticum (EC 3.2.1.22) is a glycoside hydrolase enzyme that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. Two recombinant forms of α-Galactosidase are called agalsidase alfa (INN) and agalsidase beta (INN).
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α-Glucosidase-IN-125
0 ImagesCat. No.: HY-189401α-Glucosidase-IN-125 (compound 7h) is a potent α-glucosidase (α-glucosidase) inhibitor with an IC50 of 20.73 μM. α-Glucosidase-IN-125 inhibits α-glucosidase activity by binding to the active site of α-glucosidase, thereby delaying carbohydrate digestion and reducing postprandial hyperglycemia. α-Glucosidase-IN-125 can be used for research on type 2 diabetes.
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β-Mannosidase, Bacteroides thetaiotaomicron
0 ImagesCat. No.: HY-P2858Bβ-Mannosidase, Bacteroides thetaiotaomicron (EC 3.2.1.25), is the final exoglycosidase in the N-linked glycoprotein oligosaccharide catabolism pathway. β-Mannosidase catalyzes the following chemical reaction: hydrolysis of the terminal non-reducing β-D-mannose residue in β-D-mannoside.
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2'-Rhamnoechinacoside
0 ImagesCat. No.: HY-N13188CAS No.: 1422390-59-7Synonyms: Michelioside A2'-Rhamnoechinacoside (Michelioside A), a compound of phenylethanoid glycosides, is a α-glucosidase inhibitor with anti-tumor activity, which is derived from Phlomis stewartii. 2'-Rhamnoechinacoside can be used for research of UV-absorbing and cancers.
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α-Glucosidase-IN-124
0 ImagesCat. No.: HY-189389α-Glucosidase-IN-124 is an α-glucosidase inhibitor with an IC50 of 18.55 μM. α-Glucosidase-IN-124 also exhibits inhibitory activity against α-amylase. α-Glucosidase-IN-124 delays carbohydrate digestion and reduces postprandial hyperglycemia by inhibiting α-glucosidase and α-amylase. α-Glucosidase-IN-124 can be used in diabetes-related research.
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α-Glucosidase-IN-109
0 ImagesCat. No.: HY-181091α-Glucosidase-IN-109 is an orally active α-glucosidase inhibitor with an IC50 of 0.0136 μM. α-Glucosidase-IN-109 modulates carbohydrate and lipid metabolism, reduces fasting blood glucose levels, alleviates weight loss, and exhibits protective effects on liver and kidney function. α-Glucosidase-IN-109 can be used in research related to type 2 diabetes.
