HIV Protease Inhibitor

CGP 53820 is an inhibitor for HIV protease, inhibits the complex of HIV-1 and HIV-2 protease with K_i of 9 and 53 nM for HIV-1 protease and HIV-2 protease. CGP 53820 can be used in AIDS research.

Nelfinavir-d₄ is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent.

HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC₅₀ of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants.

Atazanavir (sulfate) (Standard) is the analytical standard of Atazanavir (sulfate). This product is intended for research and analytical applications. Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM.

Indinavir sulfate ethanolate (MK-639 ethanolate) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir sulfate ethanolate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate ethanolate is also a SARS-CoV 3CL^pro inhibitor.

Mozenavir (DMP-450) is an orally active cyclic urea HIV-1 protease inhibitor with an IC₅₀ of 76 nM. Mozenavir inhibits replication by targeting viral protease, blocks viral polyprotein processing, and induces the production of core-uncondensed, immature, non-infectious viral particles in chronically infected cells. Mozenavir is applicable to research related to HIV infection.

Longipedunin A is a HIV-1 Protease inhibitor with an IC₅₀ value of 50 µg/mL.

HIV-1 protease-IN-3 (compound 14) is a potent inhibitor of HIV-1 protease (IC₅₀=71 nM; EC₅₀=0.86 μM).

Ketoprofen (lysinate) (Standard) is the analytical standard of Ketoprofen (lysinate). This product is intended for research and analytical applications. Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity.

HIV-IN petide is a competitive inhibitor of HIV-1 protease (K_i=50 nM).

U-96988 (PNU-96988) is a non-peptide HIV-1 protease inhibitor with a K_i value of 38 nM. U-96988 is also effective against HIV-2 protease. U-96988 exhibits an IC₅₀ for HIV-1_IIIB of 5 μM. U-96988 can be used for research on HIV infection.

Droxinavir (SC-55389A free base) is an HIV-1 protease inhibitor. Droxinavir binds to the S2 and S2' subsites of HIV-1 protease, and this interaction is regulated by protease amino acid residue 88, where the N88S mutation confers viral resistance. Droxinavir can be used in studies related to human immunodeficiency virus type 1 infection.

U-75875 is a HIV-1 protease inhibitor. U-75875 can block Gag-Pol protein processing and viral maturation and replication. U-75875 can be used for the research of infection.

HIV-1 protease-IN-11 (compound 34a) is a HIV-1 protease inhibitor with an IC₅₀ of 0.41 nM. HIV-1 protease-IN-11 also exhibits significant activity against drug-resistant variant.

Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum.

Tipranavir (Standard) is the analytical standard of Tipranavir. This product is intended for research and analytical applications. Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM. Tipranavir inhibits SARS-CoV-2 3CL^pro activity.

HIV-1-IN-88 (compound 20a) is a potent HIV‑1 protease inhibitor (IC₅₀ = 10 pM) with an antiviral EC₅₀ of 10.4 nM. HIV-1-IN-88 exhibits potency against the multidrug-resistant variants HIV-1_Muta and HIV-1_I50V with EC₅₀ values of 30.0 and 34.3 nM, respectively. HIV-1-IN-88 can be used for HIV research.

AG-1284 is a HIV proteinase inhibitor with an EC₅₀ of 0.5 mg/mL. AG-1284 can be used for the research of infection.

HIV-IN-12 (Compound A1) is a dual HIV-1 Vif and reverse transcriptase (RT) inhibitor. HIV-IN-12 is promising for research of HIV infections.

Saquinavir (Standard) (Ro 31-8959 (Standard)) is the analytical standard of Saquinavir (HY-17007). This product is intended for research and analytical applications. Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.