Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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1-(a-D-ribofuranosyl)uracil
0 ImagesCat. No.: HY-W128112CAS No.: 3258-07-9Synonyms: alpha-D-Ribofuranoside,2,4(1H,3H)-pyrimidinedione-11-(a-D-ribofuranosyl)uracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3'-Deoxyuridine-5'-triphosphate
0 ImagesCat. No.: HY-135780CAS No.: 69199-40-2Synonyms: 3'-dUTP3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM.
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Alpha-Adenosine
0 ImagesAlpha-Adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-Methyl-2′-O-methyl-uridine
0 ImagesCat. No.: HY-W100234CAS No.: 55486-09-4Synonyms: 2'-O-Methyl-5-methyluridine5-Methyl-2’-O-methyl-uridine (2'-O-methyl-5-methyluridine) is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis. 5-Methyl-2’-O-methyl-uridine is a modified nucleoside that can be found in tRNA isolated from rabbit liver.
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2'-Deoxyadenosine-13C10
0 ImagesCat. No.: HY-W040329S1Purity: 99.0%2'-Deoxyadenosine-13C10 is 13C-labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
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N-6-Methyl-2-deoxyadenosine-d3
0 ImagesN-6-Methyl-2-deoxyadenosine-d3 is the deuterium labeled N-6-Methyl-2-deoxyadenosine (HY-W011725). N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue.
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2’-Deoxy-2’-fluoro-b-D-arabinocytidine
0 ImagesSynonyms: 4-amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)pyrimidin-2(1H)-one2’-Deoxy-2’-fluoro-b-D-arabinocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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VP-U-6
0 ImagesCat. No.: HY-154585CAS No.: 2361324-80-1VP-U-6 is a nucleoside analog that can be used in oligonucleotide synthesis.
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Vidarabine monohydrate
0 ImagesVidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus.
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Cytidine-5'-triphosphate disodium (Standard)
0 ImagesCat. No.: HY-W013100RCAS No.: 36051-68-0Synonyms: Cytidine triphosphate disodium (Standard); 5'-CTP disodium (Standard)Cytidine-5'-triphosphate (Cytidine triphosphate) (Standard) disodium is the analytical standard of Cytidine-5'-triphosphate disodium (HY-W013100). This product is intended for research and analytical applications. Cytidine-5'-triphosphate (Cytidine triphosphate; 5'-CTP) disodium is a nucleoside triphosphate, that is invovled in biosynthesis of DNA, RNA and lipid. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate disodium is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
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Fluorescein-12-dUTP
0 ImagesCat. No.: HY-178588CAS No.: 201682-73-7Fluorescein-12-dUTP is a fluorescent labeling and detection reagent that can be used for nucleic acid synthesis. Fluorescein-12-dUTP can be used to synthesize labeled DNA probes for in situ hybridization, microarray or western blot analysis.
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5-F-UTP trisodium
0 ImagesCat. No.: HY-134178ASynonyms: 5-Fluorouridine-5'-triphosphate trisodium5-F-UTP (5-Fluorouridine-5'-triphosphate) trisodium is a monomeric raw material that can be used for nucleic acid synthesis.
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Eritadenine
0 ImagesSynonyms: Lentinacin; D-Eritadenine; LentysineEritadenine (D-Eritadenine) is a potent AdoHcyase inhibitor, with an IC50 value of 7 nM. Eritadenine is also an acyclic sugar adenosine analogue. Eritadenine exhibits an inhibitory effect on the growth of Cryptosporidium parvum, with a MIC50 of 3 μM. Eritadenine can be used in the research of colorectal adenocarcinoma.
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2′-O-(2-Methoxyethyl)guanosine
0 ImagesSynonyms: 2'-O-MOE-rG2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG) is a 2'-O-methoxyethyl-modified nucleoside analogue and an important intermediate in the synthesis of nucleic acid drugs. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA.
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FMAU
0 ImagesSynonyms: D-FMAUFMAU is a nucleoside analog and cell proliferation marker that can be phosphorylated by human thymidine kinase and subsequently incorporated into DNA. FMAU is applicable to research related to herpes simplex virus infection, various cancers, hepatitis B virus infection, and Epstein-Barr virus infection.
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DMTr-5-fluoro-2'-deoxycytidine-phosphoramidite
0 ImagesCat. No.: HY-160428CAS No.: 143774-48-5DMTr-5-fluoro-2'-deoxycytidine-phosphoramidite (compound 1B) is a phosphoramidite of 5-Fluoro-2'-deoxycytidine.
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m7GpppGmpG ammonium solution (100 mM)
0 ImagesCat. No.: HY-145977ASynonyms: m7G(5')ppp(5')(2'OMeG)pG ammoniumm7GpppGmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.
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3-Methylcytidine (Standard)
0 Images3-Methylcytidine (Standard) is the analytical standard of 3-Methylcytidine. This product is intended for research and analytical applications. 3-Methylcytidine, a urinary nucleoside, can be used as a biomarker of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.
