Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.
Opioid Receptor Isoform Specific Products
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Opioid Receptor Inhibitors
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Opioid Receptor Agonists
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Opioid Receptor Antagonists
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Opioid Receptor Activators
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Opioid Receptor Modulators
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Opioid Receptor Controls
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Opioid Receptor Ligands
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Opioid Receptor Related Products (617)
Related Products (617)
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Antibodies (3)
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Opioid Receptor Isoform Comparison
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RM1490
0 ImagesCat. No.: HY-182453CAS No.: 2849392-47-6RM1490 (Compound 251) acts as an inhibitor of μ-opioid receptor (MOR) (IC50 ≤ 300 nM), an activator of δ-opioid receptor (DOR) (EC50 > 3000 nM), and an inhibitor of κ-opioid receptor (KOR) (IC50 ≤ 300 nM). RM1490 is applicable to the research of neuropsychiatric disorders.
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ICI-199441
0 ImagesCat. No.: HY-101205ACAS No.: 116508-24-8ICI-199441 is a potent and selective κ-opioid receptor agonist with analgesic effects. ICI 199441 can improve heart resistance to ischemia/reperfusion.
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KOR agonist 6
0 ImagesCat. No.: HY-175486KOR agonist 6 is a KOR agonist (Ki = 0.25 pM). KOR agonist 6 shows agonistic activity at MOR and DOR in CHO cells and inhibits Forskolin (HY-15371)-stimulated cAMP accumulation. KOR agonist 6 stimulates KOR-mediated [35S]GTPγS binding and inhibits cAMP accumulation in KOR-expressing HEK293 cells with potent agonistic activity, while showing lower β-arrestin recruitment potency. KOR agonist 6 demonstrates anti-nociceptive efficacy in mice. KOR agonist 6 can be used for the study of analgesics with reduced central nervous system (CNS) side effects.
![[DPro10] Dynorphin A (1-11), porcine hydrochloride](https://file.medchemexpress.com/product_pic/hy-p3647a.gif "Click to View [DPro10] Dynorphin A (1-11), porcine hydrochloride Product Detail")
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ORL1 antagonist 1
0 ImagesCat. No.: HY-112263CAS No.: 1174985-59-1ORL1 antagonist 1 is an opioid receptor-like 1 (ORL1) antagonist with an IC50 of 61 nM.
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MOR agonist-1
0 ImagesCat. No.: HY-153471CAS No.: 2305781-14-8MOR agonist-1 is a MOR (μ-opioid receptor) agonist. MOR agonist-1 has good analgesic effect. MOR agonist-1 can be used for the research of pain and pain-related disorders.
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3,4-Difluoro-N,N-didesmethyl U-47700 TFA
0 ImagesCat. No.: HY-W725197CAS No.: 2751977-98-53,4-Difluoro-N,N-didesmethyl U-47700 TFA is an opioid.
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FEKAP
0 ImagesCat. No.: HY-171236CAS No.: 2324155-84-0FEKAP is a brain-penetrant and selective kappa opioid receptor (KOR) agonist (Ki = 0.43 nM) which isotope labeled form exhibits excellent imaging properties. 11C-FEKAP can be utilized as a radiotracer for imaging KOR.
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2-(Di-sec-butylamino)-1-(1-(2-fluorobenzyl)-1H-pyrrol-2-yl)ethan-1-ol
0 ImagesCat. No.: HY-W725208CAS No.: 63880-43-32-(Di-sec-butylamino)-1-(1-(2-fluorobenzyl)-1H-pyrrol-2-yl)ethan-1-ol is structurally similar to known opioids.
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N,N-didesmethyl AH 7921
0 ImagesCat. No.: HY-W046349CAS No.: 1580956-92-8N,N-didesmethyl AH 7921 is structurally categorized as an opioid metabolite and is a metabolite of AH 7921.
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BW-180C (Standard)
0 ImagesSynonyms: [D-Ala2, D-Leu5]-Enkephalin (Standard); DADLE (Standard)BW-180C (Standard) is the analytical standard of BW-180C (HY-105343). This product is intended for research and analytical applications. BW-180C ([D-Ala2, D-Leu5]-Enkephalin; DADLE) is an δ opioid receptor (DOR) agonist, which belongs to the enkephalin family. Neuroprotective agent. BW-180C reversibly inhibits cellular transcription in neurons without causing cell injury.
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ICI-204448 free acid
0 ImagesCat. No.: HY-126063CAS No.: 125190-72-9ICI-204448 free acid is a κ-opioid agonist with limited access to the CNS, ICI-204448 free acid can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes.
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Trimebutine maleate (Standard)
0 ImagesTrimebutine maleate (Standard) is the analytical standard of Trimebutine maleate (HY-B0380A). This product is intended for research and analytical applications. Trimebutine maleate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine maleate inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine maleate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine maleate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine maleate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).
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Loperamide-d6
0 ImagesSynonyms: ADL 2-1294-d6Loperamide-d6 is the deuterium labeled Loperamide.
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Opioid receptor modulator 1
0 ImagesCat. No.: HY-U00420CAS No.: 77514-44-4Opioid receptor modulator 1 is a opioid receptor modulator extracted from patent WO2014072809A2, Compound RA11 in EXAMPLE 7.
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Isopaynantheine
0 ImagesCat. No.: HY-N13293CAS No.: 22032-51-5Synonyms: 3-IsopaynantheineIsopaynantheine (3-Isopaynantheine), an alkaloid, is an opioid. Isopaynantheine has antinociceptive activity in mice.
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Nor-6α-Oxycodol
0 ImagesCat. No.: HY-114861CAS No.: 116499-16-2Nor-6α-Oxycodol is structurally similar to known opioids and is a metabolite of Oxycodone.
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Difelikefalin-d5
0 ImagesCat. No.: HY-17609SSynonyms: CR-845-d5; FE-202845-d5Difelikefalin-d5 (CR-845-d5; FE-202845-d5) is the deuterated-labeled Difelikefalin (HY-17609). Difelikefalin (CR-845; FE-202845) is an orally active peripherally acting kappa opioid receptor agonist. Difelikefalin reduces acute kidney injury, decreases oliguria, maintains urine flow, inhibits cytokine expression, and improves survival in endotoxemia after ischemia/reperfusion. Difelikefalin suppresses pruritus signals and exhibits neuromodulatory antipruritic activity. Difelikefalin can be used in research related to acute kidney injury, chronic kidney disease-associated pruritus, and atopic dermatitis.
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DuP 747
0 ImagesCat. No.: HY-120045CAS No.: 142515-44-4DuP 747 is a select opioid kappa agonist analgesic amine.
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Iprindole (Standard)
0 ImagesIprindole (Standard) is the analytical standard of Iprindole. This product is intended for research and analytical applications. Iprindole, an opioid receptor agonist, is a tricyclic antidepressant. Iprindole shortens the immobility time in mice forced swimming test, which can be reversed by the opiate antagonist Naloxone (HY-17417A). Iprindole induces lamellar body formation but devoid of lamellar bodies. Iprindole hydrochloride can be used for the research of depression.
