Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.
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Opioid Receptor Inhibitors
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Opioid Receptor Agonists
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Opioid Receptor Antagonists
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Opioid Receptor Activators
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Opioid Receptor Modulators
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Opioid Receptor Controls
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Opioid Receptor Ligands
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Opioid Receptor Verwandte Produkte (614)
Verwandte Produkte (614)
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Antibodies (3)
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Opioid Receptor Isoform Comparison
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BU09059
0 ImagesArt. -Nr.: HY-119733CAS. Nr.: 1541206-05-6BU09059 is a potent and selective Kappa-opioid receptor antagonist with a pA2 of 8.62. BU09059 has nanomolar affinity for the κ-receptor, with 15-fold and 616-fold selectivity over μ- and δ-receptors, respectively. BU09059 significantly blocks U50488 (HY-15997B)-induced antinociception.
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RO-76
0 ImagesArt. -Nr.: HY-162728RO-76 is a mu opioid receptor (μOR) selective partial agonist. RO-76 binds to μOR-G-protein complex with an EC50 value of 454 nM. RO-76 reduces β-Arrestin-1/2 recruitment. RO-76 shows antinociception activity.
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MOR agonist-2
0 ImagesArt. -Nr.: HY-155706CAS. Nr.: 2833692-02-5MOR agonist-2 (compound 46) is a antagonist of D3R and agonist of MOR (Ki: 7.26 nM and 564 nM, respectively). MOR agonist-2 has the potential to produce analgesic effects through MOR partial agonism. MOR agonist-2 reduces opioid-misuse liability via D3R antagonism.
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α-Endorphin (human, mouse, rat, porcine, bovine, ovine)
0 Imagesα-Endorphin (human, mouse, rat, porcine, bovine, ovine) is a neuropeptide, that acts on the central nervous system (CNS) and peripheral nervous system (PNS). α-Endorphin (human, mouse, rat, porcine, bovine, ovine) binds μ-opioid receptor, and exhibits analgesic efficacy. α-Endorphin (human, mouse, rat, porcine, bovine, ovine) regulates sexual behaviors and pleasure felling.
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ID110460001
0 ImagesArt. -Nr.: HY-W399025CAS. Nr.: 1110883-26-5ID110460001 is a full agonist of μ-opioid receptor and an agonist of δ-opioid receptor. ID110460001 exhibits high intrinsic efficacy for G protein pathway activation of μ-opioid receptor, and this property is not affected by the reduction in receptor quantity. ID110460001 acts only as a very weak partial agonist in the β-arrestin-2 pathway of both receptors, and binds to μ-opioid receptor via a specific mode. The efficacy of ID110460001 in the G protein pathway of δ-opioid receptor is sensitive to changes in receptor quantity. ID110460001 can be used in pain-related research.
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β-Endorphin (6-31), human
0 ImagesArt. -Nr.: HY-P3517CAS. Nr.: 77761-27-4Synonyms: β-EP (6-31), humanβ-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation.
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TIPP
0 ImagesArt. -Nr.: HY-120277CAS. Nr.: 146369-65-5Synonyms: H-Tyr-Tic-Phe-Phe-OHTIPP is a potent and selective δ-opioid antagonist with a Ki value of 1.22 nM.
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Dermorphin Analog
0 ImagesArt. -Nr.: HY-P1577CAS. Nr.: 115814-08-9Dermorphin Analog is an analog of Dermorphin. Dermorphin is a natural heptapeptide μ-opioid receptor agonist found in amphibian skin.
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Trimebutine-d5 fumarate
0 ImagesArt. -Nr.: HY-B0380S1CAS. Nr.: 2747915-18-8Trimebutine-d5 fumarate is deuterium labeled Trimebutine fumarate. Trimebutine fumarate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine fumarate inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine fumarate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine fumarate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine fumarate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).
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β-Lipotropin (60-65)
0 ImagesArt. -Nr.: HY-P3550CAS. Nr.: 60117-19-3Synonyms: β-LPH (60-65); [Arg0] Met-Enkephalinβ-Lipotropin (60-65) (β-LPH (60-65)), an opioid peptide, is a potent opioid agonist.
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Dynorphin A (1-13) amide
0 ImagesArt. -Nr.: HY-P5061CAS. Nr.: 79515-34-7Dynorphin A (1-13) amide is an endogenous opioid peptide that antagonizes morphine-induced analgesia.
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DSLET
0 ImagesArt. -Nr.: HY-P1332CAS. Nr.: 75644-90-5Synonyms: [D-Ser2, Leu5, Thr6]-enkephalinDSLET ([D-Ser2, Leu5, Thr6]-enkephalin) is a highly specific agonist of the δ-receptor. DSLET is an enkephalin-related peptide selectively bound to the δ opioid receptor.
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MOR agonist-5
0 ImagesArt. -Nr.: HY-179705CAS. Nr.: 3085132-31-3MOR agonist-5 is a selective and potent mu-opioid receptor (MOR) agonist with an EC50 of 0.25 nM. MOR agonist-5 shows an EC50 of 10 nM for DOR and >10000 nM for KOR and NOR. MOR agonist-5 exerts significant antinociceptive activity. MOR agonist-5 can be used for the research of pain.
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β-Casomorphin, human
0 ImagesArt. -Nr.: HY-P1481CAS. Nr.: 102029-74-3Synonyms: Human β-casomorphin 7is an opioid peptide, acts as an agonist of opioid receptor.
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Azo-enkephalin
0 ImagesArt. -Nr.: HY-129237CAS. Nr.: 76995-89-6Azo-enkephalin is an endorphin analog with significant analgesic activity. Azo-enkephalin can be used in the development of opioid analgesics.
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Ketazocine
0 ImagesArt. -Nr.: HY-122169CAS. Nr.: 36292-69-0Synonyms: KetocyclazocineKetazocine (Ketocyclazocine) is a selective κ-opioid receptor (KOR) agonist. Ketazocine is promising for research of analgesics and sedatives.
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RM1490
0 ImagesArt. -Nr.: HY-182453CAS. Nr.: 2849392-47-6RM1490 (Compound 251) acts as an inhibitor of μ-opioid receptor (MOR) (IC50 ≤ 300 nM), an activator of δ-opioid receptor (DOR) (EC50 > 3000 nM), and an inhibitor of κ-opioid receptor (KOR) (IC50 ≤ 300 nM). RM1490 is applicable to the research of neuropsychiatric disorders.
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ICI-199441
0 ImagesArt. -Nr.: HY-101205ACAS. Nr.: 116508-24-8ICI-199441 is a potent and selective κ-opioid receptor agonist with analgesic effects. ICI 199441 can improve heart resistance to ischemia/reperfusion.
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KOR agonist 6
0 ImagesArt. -Nr.: HY-175486KOR agonist 6 is a KOR agonist (Ki = 0.25 pM). KOR agonist 6 shows agonistic activity at MOR and DOR in CHO cells and inhibits Forskolin (HY-15371)-stimulated cAMP accumulation. KOR agonist 6 stimulates KOR-mediated [35S]GTPγS binding and inhibits cAMP accumulation in KOR-expressing HEK293 cells with potent agonistic activity, while showing lower β-arrestin recruitment potency. KOR agonist 6 demonstrates anti-nociceptive efficacy in mice. KOR agonist 6 can be used for the study of analgesics with reduced central nervous system (CNS) side effects.
