PPAR
Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating gene expression. There are three main isoforms: PPARα, PPARβ/δ, and PPARγ, each with distinct tissue distribution and biological roles. PPARα is primarily expressed in liver, heart, and muscle, where it regulates fatty acid oxidation and lipid metabolism[1]. PPARβ/δ is widely expressed and involved in energy homeostasis, glucose metabolism, and inflammation modulation[1]. PPARγ is highly expressed in adipose tissue and plays a central role in adipogenesis, insulin sensitivity, and lipid storage[2].
References:
- [1]. Man versus microbe. Nat Med. 2004 Dec;10(12 Suppl):S69. doi: 10.1038/nm1149. PMID: 15577933; PMCID: PMC7096048. et al. Nat Med. 2004 Dec;10(12 Suppl):S69. [Content Brief]
- [2]. Kiros M, et al. Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence analysis. Virol J. 2023 Oct 25;20(1):243. [Content Brief]
- [3]. Brent J, et al. Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. N Engl J Med. 1999 Mar 18;340(11):832-8. [Content Brief]
- [4]. Liu Y, et al. Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE. Nat Med. 2006 May;12(5):518-25. [Content Brief]
- [5]. Paranjape AN, et al. Introduction of SV40ER and hTERT into mammospheres generates breast cancer cells with stem cell properties. Oncogene. 2012 Apr 12;31(15):1896-909. [Content Brief]
- [6]. Iancu-Rubin C, et al. Whirling Platelets Away for Transfusion. Cell. 2018 Jul 26;174(3):503-504. [Content Brief]
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PPAR Related Products (400)
Related Products (400)
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PPARγ agonist 5
0 ImagesPPARγ agonist 5 (Compound 1) is a potent and selective agonist of PPARγ. PPARγ agonist 5 has the potential for the research of cancer diseases.
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Sodium propionate-13C
0 ImagesSodium propionate-13C is the 13C labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease.
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Elafibranor sulfoxide
0 ImagesCat. No.: HY-176510Elafibranor (GFT505) sulfoxide is a sulfoxide metabolite of Elafibranor (HY-16737). Elafibranor is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively. Elafibranor can be used for the study of primary biliary cholangitis.
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9-Octadecynoic acid
0 Images9-Octadecynoic acid is a DNA binding agent with a dissociation constant of 1.8 mM. 9-Octadecynoic acid is also an agonist for peroxisome proliferator-activated receptor γ (PPARγ).
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SR10221
0 ImagesSR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines.
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BVT.13
0 ImagesBVT.13 is an orally active and selective PPARγ agonist with a maximal efficacy similar to that of Rosiglitazone (HY-17386). In addition, BVT.13 exhibits antidiabetic activity in ob/ob mice.
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Methyl dehydroabietate
0 ImagesMethyl dehydroabietate is an orally active resin acid. Methyl dehydroabietate disrupts microbial cell walls and exhibits significant antibacterial activity. Methyl dehydroabietate induces the expression of PPARα in the liver and PPARγ in adipose tissue, and promotes adipocyte differentiation. Methyl dehydroabietate improves insulin resistance, reduces TNFα levels, and alleviates adipocyte hypertrophy and hepatic steatosis in obese mice. Methyl dehydroabietate can be used in research related to obesity, insulin resistance and hepatic steatosis.
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1-Methyladenosine-d3 hydrochloride
0 ImagesCat. No.: HY-113081ASPurity: 98.05%1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium labeled 1-Methyladenosine (HY-113081). 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis.
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Pemafibrate-d4
0 ImagesSynonyms: (R)-K-13675-d4Pemafibrate-d4 is deuterated labeled Pemafibrate (HY-17618). Pemafibrate is a highly selective PPARα agonist, with an EC50 of 1 nM.
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Oleoylethanolamide (Standard)
0 ImagesSynonyms: N-Oleoylethanolamide (Standard); Oleamide MEA (Standard); Oleic acid monoethanolamide (Standard)Oleoylethanolamide (Standard) is the analytical standard of Oleoylethanolamide. This product is intended for research and analytical applications. Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.
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Troglitazone-d4
0 ImagesSynonyms: CS-045-d4Troglitazone-d4 is deuterium labeled Troglitazone. Troglitazone is a PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively.
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SP4f
0 ImagesSP4f is an activator ofPPAR-γ, with the EC50 of 826 nM in HK-2 cells. SP4f reduces the blood glucose levels and lipid peroxidation, and increases glutathione levels and catalase activityin the Swiss albino mice.
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CCT-010354
0 ImagesCCT-010354 (Compound 63e) is an agent intermediate that can be used to synthesize PPARα/δ dual agonist.
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CUDA disodium
0 ImagesCat. No.: HY-121538APurity: 98.0%CUDA disodium is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA disodium selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA disodium may be valuable for the research of cardiovascular disease.
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E17241
0 ImagesE17241 is an inducer of the expression of ABCA1 that increases the protein levels of ABCA1 in RAW 264.7 macrophages. E17241 is also an agonist of peroxisome proliferator-activated receptors (PPARs ). E17241 decreases plasma glucose levels and body weight in KKAy diabetic mice fed a high-fat and high-glucose (HFHG) diet.
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Ragaglitazar
0 ImagesSynonyms: (-)-DRF 2725; NNC 61-0029
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15-Deoxy-Δ-12,14-prostaglandin J2-d4
0 ImagesSynonyms: 15d-PGJ2-d4; 15-Deoxy-Δ12,14-PGJ2-d415-Deoxy-Δ-12,14-prostaglandin J2-d4 is the deuterium labeled 15-Deoxy-Δ-12,14-prostaglandin J2. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 μM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.
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Ppara Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS10920Ppara Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppara gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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ISX-3
0 ImagesISX-3 is a potent anti-adipogenic and pro-osteogenic agent. ISX-3 increases the expression of PPARγ. ISX-3 has the potential for the research of osteopenia and osteoporosis.
