Phosphodiesterase (PDE)
Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.
Phosphodiesterase (PDE) Isoform Specific Products
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Phosphodiesterase (PDE)
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PDE1
(60)
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PDE2
(51)
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PDE3
(93)
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PDE4
(197)
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PDE5
(97)
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PDE6
(22)
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PDE7
(28)
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PDE9
(19)
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PDE10
(53)
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PDE11
(13)
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PDE12
(2)
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PDE8
(11)
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Autotaxin
(36)
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All Product Categories
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Phosphodiesterase (PDE) Inhibitors
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Phosphodiesterase (PDE) Agonists
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Phosphodiesterase (PDE) Antagonists
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Phosphodiesterase (PDE) Activators
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Phosphodiesterase (PDE) Modulators
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Phosphodiesterase (PDE) Degraders
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Phosphodiesterase (PDE) Controls
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Phosphodiesterase (PDE) Substrates
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Phosphodiesterase (PDE) Ligand
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Phosphodiesterase (PDE) Related Products (1006)
Related Products (1006)
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Antibodies (4)
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Phosphodiesterase (PDE) Isoform Comparison
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Leniquinsin
0 ImagesCat. No.: HY-113892CAS No.: 10351-50-5Synonyms: U-1085Leniquinsin is a phosphodiesterase inhibitor, which is used as a vasodilator.
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OPC 3911
0 ImagesCat. No.: HY-165568CAS No.: 76470-87-6OPC 3911 is a highly selective inhibitor of cGMP-inhibited cAMP phosphodiesterase (cGI-PDE/PDE3) and a vasodilator, with an IC50 of 0.042 μM against rat cGI-PDE. OPC 3911 upregulates the expression of Osteopontin. OPC 3911 mediates vasodilation of arterial smooth muscle, induces vasodilatory responses in isolated rat arteriovenous tissues, and exhibits additive vasodilatory effects with Isoprenaline (HY-108353) and Forskolin (HY-15371). OPC 3911 can be used in studies related to congestive heart failure and insulin resistance.
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Braylin
0 ImagesBraylin, a coumarin, is a potent phosphodiesterase-4 (PDE4) inhibitor and is involved in anti-inflammatory and immunomodulation, which may serve as a potential target for the study of immunoinflammatory diseases.
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RS-25344 hydrochloride (Standard)
0 ImagesCat. No.: HY-108621RCAS No.: 152815-28-6RS-25344 hydrochloride (Standard) is the analytical standard of RS-25344 (hydrochloride) (HY-108621). This product is intended for research and analytical applications. RS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC50 of 0.28 nM in human lymphocytes. RS-25344 hydrochloride has only weak inhibitory effects on PDE I, II, III (IC50 of >100 μM, 160 μM, 330 μM, respectively). RS-25344 hydrochloride has anti-inflammatory, memory- and cognition enhancing, and antineoplastic effects.
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MK-0952 (Standard)
0 ImagesCat. No.: HY-11070RCAS No.: 934995-87-6
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Furamidine dihydrochloride (Standard)
0 ImagesCat. No.: HY-110137RCAS No.: 55368-40-6Synonyms: DB75 dihydrochloride (Standard); NSC 305831 dihydrochloride (Standard)Furamidine (dihydrochloride) (Standard) is the analytical standard of Furamidine (dihydrochloride). This product is intended for research and analytical applications. Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent.
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Desmethyl thiosildenafil
0 ImagesCat. No.: HY-131473CAS No.: 479073-86-4Desmethyl thiosildenafil is a phosphodiesterase type 5 (PDE5) inhibitor[1].
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JNJ-10258859
0 ImagesCat. No.: HY-123145CAS No.: 374927-03-4JNJ-10258859 is a potent and selective phosphodiesterase type 5 inhibitor, with a Ki of 0.23 nM. JNJ-10258859 can be used for erectile dysfunction research.
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Eurycomanone (Standard)
0 ImagesCat. No.: HY-N5012RCAS No.: 84633-29-4Synonyms: Pasakbumin A (Standard)Eurycomanone (Standard) is the analytical standard of Eurycomanone. This product is intended for research and analytical applications. Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.
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5,6-DM-cBIMP
0 ImagesCat. No.: HY-131824CAS No.: 142754-31-2
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MMPX
0 ImagesCat. No.: HY-100990CAS No.: 78033-08-6MMPX is a potent PDE1 inhibitor.
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SDZ-MKS 492 (Standard)
0 ImagesCat. No.: HY-100164RCAS No.: 114606-56-3Synonyms: MKS 492 (Standard)SDZ-MKS 492 (Standard) is the analytical standard of SDZ-MKS 492 (HY-100164). This product is intended for research and analytical applications. SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats.
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BMS-341400 mesylate
0 ImagesCat. No.: HY-107022ACAS No.: 296250-54-9BMS-341400 mesylate is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM. BMS-341400 mesylate reduces the degradation of cyclic guanosine monophosphate (cGMP), thereby enhancing nitric oxide (NO)-mediated relaxation of the smooth muscle of the corpus cavernosum and promoting erection. BMS-341400 mesylate can be used to study erectile dysfunction.
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BAY 73-6691 (Standard)
0 ImagesCat. No.: HY-104028RCAS No.: 794568-92-6BAY 73-6691 (Standard) is the analytical standard of BAY 73-6691 (HY-104028). This product is intended for research and analytical applications. BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor.
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Sequoiaflavone
0 ImagesCat. No.: HY-119416CAS No.: 21763-71-3Sequoiaflavone is a biflavonoid compound with multiple activities. Sequoiaflavone suppresses hepatic CYP1A1/(7-Ethoxycoumarin O-deethylase) ECOD, prevents Aβ1-42 fibrillization (IC50 = 0.29 μM) and disaggregates amyloid fibrils (EC50 = 2.04 μM), inhibits Alternaria alternata and inhibits human recombinant PDE5A1 overexpressed in COS-7 cells (IC50 = 19.9 μM) to exert NO-independent vasodilation. Sequoiaflavone can be used in Alzheimer's disease, peripheral circulatory disorder, and antifungal research.
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Fenspiride hydrochloride (Standard)
0 ImagesFenspiride (hydrochloride) (Standard) is the analytical standard of Fenspiride (hydrochloride). This product is intended for research and analytical applications. Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases.
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GSK256066 (Standard)
0 ImagesGSK256066 (Standard) is the analytical standard of GSK256066. This product is intended for research and analytical applications. GSK256066 is a selective and high-affinity phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 3.2 pM for PDE4B. GSK256066 is developed for the research of chronic obstructive pulmonary disease.
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Irsogladine (Standard)
0 ImagesSynonyms: Dicloguamine (Standard)Irsogladine (Standard) is the analytical standard of Irsogladine. This product is intended for research and analytical applications. 0
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Roflumilast Impurity E (Standard)
0 ImagesCat. No.: HY-100640RCAS No.: 1391052-76-8Roflumilast Impurity E (Standard) is the analytical standard of Roflumilast Impurity E. This product is intended for research and analytical applications. Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast(Daliresp) is a agent which acts as a selective and long-acting inhibitor of the enzyme PDE-4 with an IC50 value of 0.8 nM.
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NHTD
0 ImagesCat. No.: HY-164513CAS No.: 2540915-70-4NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC).
