2. Signaling Pathways
  3. Immunology/Inflammation
  4. CD74
  5. CD74 Inhibitor

CD74 Inhibitor

CD74 Inhibitors (8):

Cat. No. Product Name Effect Purity
  • HY-P99731
    Milatuzumab
    		Inhibitor 99.39%
    Milatuzumab (hLL1; MEDI-115) is a humanized anti-CD74 monoclonal antibody. CD74, a integral membrane protein, is associated with the promotion of B-cell growth and survival. Milatuzumab causes free radical oxygen generation, and loss of mitochondrial membrane potential. Milatuzumaba also decreases CD20/CD74 aggregates and cell adhesion, to lead to cell death.
  • HY-103333
    Arvanil
    		Inhibitor 99.1%
    Arvanil (N-Vanillylarachidonamide) is a mixed agonist of CB1 and TRPV1 receptors. Arvanil downregulates CD25, HLA-DR, CD134/OX40, blocks G1/S phase transition, and induces phosphorylation of Akt. Arvanil does not induce apoptosis in cells. Arvanil inhibits lymphocyte activation and ameliorates autoimmune encephalomyelitis. Arvanil can be used in research related to Huntington's disease, vomiting, and multiple sclerosis.
  • HY-P990728
    Bezetabart
    		Inhibitor 99.00%
    Bezetabart is an anti-CD74 human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-P991844
    Anti-HLA-DQ Antibody (1a3)
    		Inhibitor
    Anti-HLA-DQ Antibody (1a3) reacts with human HLA-DQ. HLA-DQ (DQ) is a cell surface receptor protein found on antigen-presenting cells. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978).
  • HY-P991837
    Anti-HLA-DP Antibody (B7/21)
    		Inhibitor
    Anti-HLA-DP Antibody (B7/21) reacts with the class II major histocompatibility complex (MHC) antigen. Anti-HLA-DP Antibody (B7/21) recognizes a monomorphic determinant present on cells expressing DP1, DP2, DP3, DP4 and DP5. Recommend Isotype Controls: Mouse IgG3 kappa, Isotype Control (HY-P99985).
  • HY-N2245
    Schisandrone
    		Inhibitor 99.78%
    Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera. Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia.
  • HY-128356
    SPL-410
    		Inhibitor 99.38%
    SPL-410 is an orally active, highly potent and selective hydroxyethylamine based SPPL2a (Signal Peptide Peptidase Like 2a) inhibitor, with an IC50 of 9 nM.
  • HY-107101
    (5R)-5-Hydroxytriptolide
    		Inhibitor 99.67%
    (5R)-5-Hydroxytriptolide is an extracted compound from Tripterygium, and shows lower cell cytotoxicity and higher immunosuppressive activity. (5R)-5-Hydroxytriptolide can be used for study of rheumatoid arthritis.