Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Related Products (4062)
Related Products (4062)
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1-(1-Adamantyl)-3-butyl-2-thiourea
0 ImagesCat. No.: HY-167919CAS No.: 25444-87-51-(1-Adamantyl)-3-butyl-2-thiourea is a compound with antiviral activity, demonstrating efficacy against various viral pathogens; 1-(1-Adamantyl)-3-butyl-2-thiourea serves as a potential therapeutic agent in the treatment of viral infections.
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Anticancer agent 344
0 ImagesCat. No.: HY-184947CAS No.: 3099598-95-2Anticancer agent 344 is a heterobifunctional anticancer compound with moderate cancer cell growth inhibitory activity, and it also exhibits inhibitory activity against ERα-overexpressing cells. Anticancer agent 344 can be used in cancer-related research.
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4-Methoxy-α-pyrrolidinopropiophenone tosylate
0 ImagesCat. No.: HY-158805CAS No.: 2748561-60-4Synonyms: 4'-MeO-α-ppp tosylate; 4'-Meoppp tosylate; Moppp tosylate4-Methoxy-α-pyrrolidinopropiophenone (4'-MeO-α-ppp) tosylate is a biomolecule.
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Lianqiaoxinoside C
0 ImagesCat. No.: HY-N17514CAS No.: 1802416-77-8Lianqiaoxinoside C is a natural product that can be found in Forsythia suspensa?(Thunb.) Vahl.
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Loncipoetin alfa
0 ImagesCat. No.: HY-P992119CAS No.: 3052736-86-1Loncipoetin alfa is a mutant of human erythropoietin, which can be used in the research of anemia.
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Esterbut-6
0 ImagesCat. No.: HY-118719CAS No.: 125161-48-0Esterbut-6 is an active compound.
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Antiproliferative agent-76
0 ImagesCat. No.: HY-182053CAS No.: 33757-62-9Antiproliferative agent-76 (Compound II-2) is an 8-sulfonamidoquinoline derivative and a selective anticancer agent. Antiproliferative agent-76 blocks the NF-κB and WNT signaling pathways. Antiproliferative agent-76 promotes cancer cell Apoptosis. Antiproliferative agent-76 exhibits anticancer activity against colorectal cancer and leukemia.
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12-O-Methylinophyllum D
0 ImagesCat. No.: HY-N13802CAS No.: 40883-10-1Synonyms: 12-Methoxyinophyllum D12-O-Methylinophyllum D (12-Methoxyinophyllum D) is a natural coumarin.
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(Rac)-Luciferin 6′-methyl ether sodium
0 ImagesCat. No.: HY-115749ACAS No.: 646450-23-9Synonyms: (Rac)-6′-Methoxyluciferin sodiumD-Luciferin 6′-methyl ether (6′-Methoxyluciferin; compound 19a) sodium is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC50 of 0.1 μM. D-Luciferin 6′-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site.
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BIBW 22
0 ImagesCat. No.: HY-123360CAS No.: 137694-16-7Synonyms: BIBW22BSBIBW 22 (BIBW22BS) is a dipyridamole analogue. BIBW 22 is a potent bifunctional modulator that affects p-glycoprotein and nucleoside transport in tumor cells.
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Emeheterone
0 ImagesCat. No.: HY-N8957CAS No.: 117333-12-7Emeheterone is a natural alkaloid.
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Aminopentamide
0 ImagesAminopentamide is a structural analog of Disopyramide (HY-12533) and parasympatholytic agent.
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pNPS-DHA
0 ImagesCat. No.: HY-139247CAS No.: 2454246-25-2pNPS-DHA (Compound 19) is an orally active DHA-ethanolamide (DHEA) derivative that has antiallergic activity. pNPS-DHA inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice. pNPS-DHA has anti-degranulating activity in RBL-2H3 mast cells with an IC50 of 15 μM.
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anti-TNBC agent-10
0 ImagesCat. No.: HY-175544CAS No.: 2923722-02-3anti-TNBC agent-10 is an anti-TNBC agent. anti-TNBC agent-10 shows potent anti-TNBC activity against BT549 cells (IC50 = 0.018 μM) and maintains activity against MDA-MB-231 cells (IC50 = 4.16 μM). anti-TNBC agent-10 9 demonstrates significant anti-tumor efficacy in mice bearing subcutaneous MDA-MB-231 TNBC xenografts. anti-TNBC agent-10 can be used for the study of triple-negative breast cancer (TNBC).
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Afeletecan
0 ImagesCat. No.: HY-123043CAS No.: 215604-75-4Synonyms: BAY 56-3722 free base; BAY-383441 free baseAfeletecan is an active compound.
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Fmoc-NH-C2-diphosphate-dexamethasone
0 ImagesCat. No.: HY-180953CAS No.: 1815577-55-9Fmoc-NH-C2-diphosphate-dexamethasone (Compound 17) is a derivative of Dexamethasone (HY-14648) and can be used as a drug intermediate for the synthesis of the Raltitrexed (HY-10821)-Dexamethasone conjugate.
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(-)-Lyoniresinol 9-O-glucoside
0 ImagesCat. No.: HY-N17178CAS No.: 162613-63-0(-)-Lyoniresinol 9-O-glucoside is a natural lignan.
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9-Hydroxy-13E-labden-15-oic acid
0 ImagesCat. No.: HY-N7184CAS No.: 132915-47-09-Hydroxy-13E-labden-15-oic acid is a natural diterpene.
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(+)-Mornaphthoate C
0 ImagesCat. No.: HY-N17498CAS No.: 2409077-02-5
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MNA 279
0 ImagesCat. No.: HY-129442CAS No.: 185915-32-6Synonyms: X 910279; HMR-279; FK-779MNA 279 (X 910279) is an orally active, immunosuppressive malononitrilamide and A 771726 derivative. MNA 279 suppresses IgM and IgG antibody production. MNA 279 prevents the development of systemic lupus erythematosus (SLE)-like disease in mice. MNA 279 prolongs skin xenograft survival in a mouse-to-rat model.
