mAChR
Muscarinic acetylcholine receptor
mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.
mAChR Isoform Specific Products
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mAChR Inhibitors
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mAChR Agonists
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mAChR Antagonists
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mAChR Activators
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mAChR Modulators
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mAChR Inducer
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mAChR Controls
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mAChR Ligands
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mAChR Related Products (727)
Related Products (727)
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Antibodies (2)
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mAChR Isoform Comparison
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KTX-005
0 ImagesCat. No.: HY-173031CAS No.: 162182-77-6KTX-005 is the agonist for mAChR that regulates the signaling pathway of the neurotransmitter acetylcholine, and can be used for research of schizophrenia.
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PF-3635659
0 ImagesCat. No.: HY-15502CAS No.: 931409-24-4PF-3635659 is a potent antagonist of the muscarinic M3 receptor (mAChR3). PF-3635659 can be used for chronic obstructive pulmonary disease (COPD) research.
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Ipratropium-d7 bromide
0 ImagesCat. No.: HY-B0241S1Synonyms: Sch 1000-d7 bromideIpratropium-d7 (bromide)eis the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma.
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VU0357017
0 ImagesCat. No.: HY-19752CAS No.: 1135681-23-0Synonyms: CID-25010775 free baseVU0357017 (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM). VU0357017 can be used for the research of Alzheimer’s disease and schizophrenia.
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RLH-033
0 ImagesCat. No.: HY-120842CAS No.: 157097-10-4RLH-033 is a potent and selective ligand for the sigma 1 recognition site. RLH-033 has high affinity for sigma 1 sites labeled by [3H](+)-pentazocine with a Ki of 50 pM.
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Pirenzepine dihydrochloride (Standard)
0 ImagesSynonyms: LS 519 (Standard); Pirenzepin dihydrochloride (Standard); Gastrozepin dihydrochloride (Standard)Pirenzepine (dihydrochloride) (Standard) is the analytical standard of Pirenzepine (dihydrochloride). This product is intended for research and analytical applications. Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells.
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AQ-RA 721
0 ImagesCat. No.: HY-126862CAS No.: 139051-89-1AQ-RA 721 is a muscarinic receptor antagonist with differential affinity for the m4 and M2 sites, which can be used to characterize muscarinic receptor subtypes. Other muscarinic receptor antagonists have differential affinity for the M1 (rat cerebral cortex), M2 (rat heart), M3 (rat submandibular gland), m4 (receptor expressed in Chinese hamster ovary cells transfected with CHO), and guinea pig uterine smooth muscle at the muscarinic binding site.
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Sabcomeline
0 ImagesCat. No.: HY-106432CAS No.: 159912-53-5Synonyms: SB-202026; MemricSabcomeline (SB-202026) is a potent and functionally selective muscarinic M1 receptor partial agonist that improve cognition. Sabcomeline can be used for Alzheimer's disease research.
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trans-Cevimeline hydrochloride
0 ImagesCat. No.: HY-116459CAS No.: 107220-29-1Synonyms: AF102A hydrochlorideTrans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease.
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Fazadinium bromide
0 ImagesCat. No.: HY-127147CAS No.: 49564-56-9Synonyms: AH 8165 bromideFazadinium bromide (AH 8165 bromide) is a species-specific neuromuscular blocking agent that primarily targets the acetylcholine receptor (AChR) at the skeletal neuromuscular junction, blocking the receptor agonist binding site in a competitive and reversible manner. Fazadinium bromide induces sustained tetanic fade, and tetanic contractions are more sensitive than single twitches. Fazadinium bromide can be used in anesthesia and research related to neuromuscular transmission.
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Methacholine chloride (Standard)
0 ImagesMethacholine (chloride) (Standard) is the analytical standard of Methacholine (chloride). This product is intended for research and analytical applications. Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates.
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Pilocarpine nitrate (Standard)
0 ImagesPilocarpine (nitrate) (Standard) is the analytical standard of Pilocarpine (nitrate). This product is intended for research and analytical applications. Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
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AE9C90CB
0 ImagesCat. No.: HY-134971CAS No.: 893426-98-7AE9C90CB, muscarinic receptor antagonist, has greater affinity for M3 muscarinic receptors with pKi of 9.90 and was 20-fold more selective for M3 than for M2 muscarinic receptors.
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Secoverine
0 ImagesCat. No.: HY-183540CAS No.: 57558-44-8Secoverine is a muscarinic cholinergic receptor (mAChR) antagonist and antispasmodic with blood-brain barrier permeability. Secoverine binds competitively to muscarinic receptors, blocks central cholinergic effects, and inhibits cholinergically induced gastrointestinal motility, intestinal smooth muscle contraction, and acetylcholine-mediated neurotransmitter release. Secoverine exerts direct antispasmodic activity on intestinal smooth muscle independent of receptor blockade, and exhibits characteristics such as reversible smooth muscle activity and long duration of action. Secoverine can be used in studies related to hyperintestinal motility, diverticular disease, and colonic spasm.
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Olanzapine-d4
0 ImagesCat. No.: HY-14541S1CAS No.: 1252611-62-3Synonyms: LY170053-d4
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RHC 80267 (Standard)
0 ImagesCat. No.: HY-107416RCAS No.: 83654-05-1Synonyms: U-57908 (Standard)RHC 80267 (Standard) is the analytical standard of RHC 80267 (HY-107416). This product is intended for research and analytical applications. RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC50 of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC50 of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC).
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Cevimeline hydrochloride hemihydrate (Standard)
0 ImagesCat. No.: HY-76772RCAS No.: 153504-70-2Synonyms: SNI-2011 (Standard); AF102B hydrochloride hemihydrate (Standard)Cevimeline (hydrochloride hemihydrate) (Standard) is the analytical standard of Cevimeline (hydrochloride hemihydrate). This product is intended for research and analytical applications. Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB).
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CDD0102 hydrochloride
0 ImagesCat. No.: HY-U00230ACAS No.: 1196130-86-5CDD0102 Hydrochloride is a potent M1 Muscarinic receptor agonist.
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Piperidolate (Standard)
0 ImagesCat. No.: HY-B0962ARCAS No.: 82-98-4Piperidolate (Standard) is the analytical standard of Piperidolate. This product is intended for research and analytical applications. Piperidolate is a cholinergic antagonist. Piperidolate prevents ventricular fibrillation during hypothermic cardiac manipulations to support cardiac procedures post-preoperative defibrillation. Piperidolate causes dose-dependent cardiac depression. Piperidolate can be used for the research of ventricular fibrillation.
