nAChR
Nicotinic acetylcholine receptors
nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".
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nAChR Related Products (484)
Related Products (484)
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Antibodies (5)
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S 24795 (Standard)
0 ImagesCat. No.: HY-11053RCAS No.: 304679-75-2
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Hydroxy Varenicline
0 ImagesCat. No.: HY-114736CAS No.: 357424-21-6Synonyms: 2-Hydroxyvarenicline
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Magnocurarine chloride
0 ImagesCat. No.: HY-N6609BCAS No.: 75413-87-5Magnocurarine chloride is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine chloride exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine chloride does not affect the spinal multineuronal reflex in frogs. Magnocurarine chloride exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models.
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bPiDDB (Standard)
0 ImagesCat. No.: HY-107674RCAS No.: 525596-66-1bPiDDB (Standard) is the analytical standard of bPiDDB (HY-107674). This product is intended for research and analytical applications. bPiDDB is a potent nAChR antagonist. bPiDDB potently (IC50=2 nM) inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs.
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3-Pyr-Cytisine
0 ImagesCat. No.: HY-107680CAS No.: 948027-43-8Synonyms: 3-Pyr-Cyt3-Pyr-Cytisine (3-Pyr-Cyt) is a cytisine derivative. 3-Pyr-Cytisine is a very weak α4β2 nAChR partial agonist that has been studied as an antidepressant.
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18-Methoxycoronaridine
0 ImagesCat. No.: HY-106980CAS No.: 308123-60-6Synonyms: (-)-18-Methoxycoronaridine18-Methoxycoronaridine ((-)-18-Methoxycoronaridine) is an orally active and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist. 18-Methoxycoronaridine is an inhibitor of serotonin transporter (SERT) and norepinephrine transporter (NET), with IC50 values of 51.6 μM and 121 μM for SERT and NET, respectively. 18-Methoxycoronaridine inhibits the function of SERT and NET, promotes 5-HT3A receptor desensitization, blocks α3β4 nAChR, and modulates receptor signaling pathways associated with reinforcement. 18-Methoxycoronaridine also exhibits potent antiparasitic activity. 18-Methoxycoronaridine can be used in research related to depression, obesity, alcoholism, smoking addiction, and cutaneous leishmaniasis.
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Sofinicline benzenesulfonate
0 ImagesCat. No.: HY-14824ACAS No.: 876170-44-4Synonyms: ABT 894 benzenesulfonateSofinicline benzenesulfonate (ABT 894 benzenesulfonate) is a novel nicotinic acetylcholine receptor agonist, specifically acting on the α4β2 subtype of nAChR (IC50=0.1 nM). Sofinicline benzenesulfonate has the potential to improve cognitive function, including attention, memory and working memory. Sofinicline benzenesulfonate can be used in studies of attention deficit, hyperactivity disorder (ADHD).
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Microgrewiapine A
0 ImagesCat. No.: HY-N10132CAS No.: 1420777-30-5
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Desformylflustrabromine hydrochloride (Standard)
0 ImagesCat. No.: HY-107675RCAS No.: 951322-11-5Synonyms: Deformylflustrabromine hydrochloride (Standard); dFBr hydrochloride (Standard)Desformylflustrabromine hydrochloride (Standard) is the analytical standard of Desformylflustrabromine hydrochloride (HY-107675). This product is intended for research and analytical applications. Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48.
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Insecticidal agent 20
0 ImagesCat. No.: HY-173073Insecticidal agent 20 (Compound 17) is an insecticide that can bind to AChBP. Insecticidal agent 20 exhibits good insecticidal activity against the larvae (LC50: 1.57 ppm) and pupae (LC50: 4.17 ppm) of Culex pipiens.
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4BP-TQS (Standard)
0 ImagesCat. No.: HY-110087RCAS No.: 360791-49-7
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Varenicline (Standard)
0 ImagesSynonyms: CP 526555 (Standard)Varenicline (Standard) is the analytical standard of Varenicline. This product is intended for research and analytical applications. Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC50 = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α7β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation.
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Facinicline
0 ImagesCat. No.: HY-108057CAS No.: 677306-35-3Synonyms: RG3487 free baseFacinicline (RG3487) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM.
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Vecuronium bromide (Standard)
0 ImagesSynonyms: ORG NC 45 (Standard)Vecuronium (bromide) (Standard) is the analytical standard of Vecuronium (bromide). This product is intended for research and analytical applications. Vecuronium (ORG NC 45) bromide is a non-depolarizing neuromuscular blocking agent that also acts as a nicotinic acetylcholine receptor (nAChR) inhibitor, a muscle relaxant, and can be used for pre-surgical anesthesia.
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AChE/nAChR-IN-1
0 ImagesCat. No.: HY-175607CAS No.: 59417-09-3
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(±) Anabasine hydrochloride
0 ImagesCat. No.: HY-W209279CAS No.: 352220-15-6(±) Anabasine hydrochloride is the racemic form of Anabasine (HY-B1532). (±) Anabasine hydrochloride stimulates the release of [3H]-Dopamine from mouse striatal synaptosomes. (±) Anabasine hydrochloride inhibits the high-affinity binding of [3H]-S-(-)-Nicotine to the striatal membrane. Anabasine hydrochloride is an agonist of α7nAChR and possesses anti-inflammatory and insecticidal activities.
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UFR2709 hydrochloride
0 ImagesCat. No.: HY-137231CAS No.: 100609-40-3UFR2709 hydrochloride is a blood-brain barrier-permeable, non-selective competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChR). UFR2709 hydrochloride exerts anxiolytic effects in adult zebrafish, reduces alcohol-seeking behavior, ethanol consumption and ethanol preference in rats, increases water intake in rats, and does not alter locomotor/grooming activity or body weight in rats. UFR2709 hydrochloride can be used in research related to anxiety disorders, nicotine addiction, alcoholism and alcohol dependence.
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(±)-Epibatidine dihydrochloride
0 ImagesSynonyms: CMI 545 dihydrochloride(±)-Epibatidine (CMI 545) dihydrochloride is a neuronal nicotinic acetylcholine receptor (nAChR) agonist that targets brain nicotinic receptors, inhibits afferent micturition pathways and sensory pathways, thereby inhibiting the micturition reflex and mediating antihyperalgesic effects. (±)-Epibatidine dihydrochloride can be used for research on trigeminal neuralgia.
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Varenicline-13C,15N
0 ImagesCat. No.: HY-10019S2CAS No.: 2140265-12-7Synonyms: CP 526555-13C,15NVarenicline-13C15N (CP 526555-13C15N) is 13C and 15N labeled Varenicline. Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC50 = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α7β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation.
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DBO-83 free base
0 ImagesCat. No.: HY-167129CAS No.: 286946-32-5DBO-83 free base is a brain-penetrant nicotinic acetylcholine receptor (nAChR) agonist. DBO-83 free base activates peripheral nicotinic acetylcholine receptors to evoke non-stimulated ileum contractions. DBO-83 free base shows antinociceptive and anti-amnesic activities.
