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Cat. No.: HY-48682

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AKT ligand-2

AKT ligand-2 (compound 5) is an AKT ligand. AKT ligand-2 can be combined with VHL ligand (S,R,S)-AHPC (HY-125845) through linker to synthesize PROTAC MS21 (HY-141807).

For research use only. We do not sell to patients.

CAS No.: 2376139-61-4
Formula: C₃₀H₄₁ClN₈O₃
Molecular Weight:597.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AKT ligand-2 Chemical Structure

CAS No.: 2376139-61-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

AKT ligand-2 (compound 5) is an AKT ligand. AKT ligand-2 can be combined with VHL ligand (S,R,S)-AHPC (HY-125845) through linker to synthesize PROTAC MS21 (HY-141807)^[1].

All Akt Isoforms :

Chemical Information

CAS No. 2376139-61-4
Molecular Weight 597.15
Formula C₃₀H₄₁ClN₈O₃
SMILES

ClC(C=C1)=CC=C1[C@H](CCN2CCNCC2)NC(C3(CCN(C4=C5C(NC=C5)=NC=N4)CC3)NC(OC(C)(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu J, et al. AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B. Cancer Discov. 2021 Dec [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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