Aleuritic acid
Based on 1 publication(s) in Google Scholar
Aleuritic acid ((±)-erythro-Aleuritic acid; α-Aleuritic acid) is a polyhydroxy fatty acid found in plant cutin and shellac. Aleuritic acid disrupts the Mycobacterium tuberculosis Nei2-β-clamp (DnaN) interaction and binds to the Mycobacterium tuberculosis β-clamp without affecting the intrinsic DNA glycosylase activity of Nei2. Aleuritic acid self-assembles with pectin to form cutin body nanoparticles. Aleuritic acid is the major component of Croton crassifolius. Aleuritic acid is used in mycobacterial and fragrance-related research.
For research use only. We do not sell to patients.
- Purity : 99.73%
- CAS No.: 533-87-9
- Formula: C16H32O5
- Molecular Weight:304.42
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Aleuritic acid
More
Biological Activity
Description
In Vitro
Aleuritic acid (50-800 µM; 30 min) inhibits the interaction between Mycobacterium tuberculosis Nei2 and the β clamp with an IC50 of 71.49 µM, without affecting the intrinsic glycosylase activity of MtbNei2[2].
Aleuritic acid binds to the Mycobacterium tuberculosis β-clamp with a KD of 27 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 533-87-9
-
Appearance Solid
-
Molecular Weight 304.42
-
Formula C16H32O5
-
Color White to off-white
-
SMILES
OCCCCCC[C@H](O)[C@H](O)CCCCCCCC(O)=O
-
Synonyms
(±)-erythro-Aleuritic acid; α-Aleuritic acid
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Cell Rep
2025 Apr 16;44(5):115572. PMID: 40249703
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (328.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.21 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.21 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2849 mL | 16.4247 mL | 32.8494 mL | 82.1234 mL |
| 5 mM | 0.6570 mL | 3.2849 mL | 6.5699 mL | 16.4247 mL | |
| 10 mM | 0.3285 mL | 1.6425 mL | 3.2849 mL | 8.2123 mL | |
| 15 mM | 0.2190 mL | 1.0950 mL | 2.1900 mL | 5.4749 mL | |
| 20 mM | 0.1642 mL | 0.8212 mL | 1.6425 mL | 4.1062 mL | |
| 25 mM | 0.1314 mL | 0.6570 mL | 1.3140 mL | 3.2849 mL | |
| 30 mM | 0.1095 mL | 0.5475 mL | 1.0950 mL | 2.7374 mL | |
| 40 mM | 0.0821 mL | 0.4106 mL | 0.8212 mL | 2.0531 mL | |
| 50 mM | 0.0657 mL | 0.3285 mL | 0.6570 mL | 1.6425 mL | |
| 60 mM | 0.0547 mL | 0.2737 mL | 0.5475 mL | 1.3687 mL | |
| 80 mM | 0.0411 mL | 0.2053 mL | 0.4106 mL | 1.0265 mL | |
| 100 mM | 0.0328 mL | 0.1642 mL | 0.3285 mL | 0.8212 mL |
Aleuritic acid Related Classifications
HY-N7076 Related Classifications
Powered by Bioz
Keywords
- Aleuritic acid
- 533-87-9
- (±)-erythro-Aleuritic acid
- α-Aleuritic acid
- Bacterial
- Biochemical Assay Reagents
- Mycobacterium tuberculosis β-clamp
- autophagic flux
- nociceptive behavior
- liver cancer cells
- capsaicin
- hypertonic saline
- acid saline
- cGMP signaling
- mitochondria-dependent apoptosis
- Nei2-β-clamp interaction
- Inhibitor
- inhibitor
- inhibit