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Beta-Sitosterol (purity>80%)

22 Cited Publications
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Based on 22 publication(s) in Google Scholar

Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.

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  • Reinheit: 94.91%
  • CAS. Nr.: 83-46-5
  • Formel: C29H50O
  • Molecular Weight:414.71
  • Speicherung:

    -20°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Beta-Sitosterol (purity>80%) Chemical Structure
  • Experimental Validation Results for Beta-Sitosterol (purity>80%)
  • Experimental Validation Results for Beta-Sitosterol (purity>80%)
  • Experimental Validation Results for Beta-Sitosterol (purity>80%)
  • Experimental Validation Results for Beta-Sitosterol (purity>80%)
  • Experimental Validation Results for Beta-Sitosterol (purity>80%)
  • Beta-Sitosterol (purity>80%) Chemical Structure
    Beta-Sitosterol (purity>80%) Chemical Structure
  • Experimental Validation Results for Beta-Sitosterol (purity>80%)
  • Experimental Validation Results for Beta-Sitosterol (purity>80%)
  • Experimental Validation Results for Beta-Sitosterol (purity>80%)
  • Experimental Validation Results for Beta-Sitosterol (purity>80%)
  • Experimental Validation Results for Beta-Sitosterol (purity>80%)
CAS. Nr.: 83-46-5
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  • Beta-Sitosterol (purity>80%) Chemical Structure
    Beta-Sitosterol (purity>80%) Chemical Structure
    1/16
  • 1/16

    Beta-Sitosterol (purity>80%) purchased from MedChemExpress. Usage Cited in: Front Oncol. 2022 Aug 10;12:882784. [Abstract]

    Customer Validation
     TNBC cells were simultaneously treated with quercetin and/or β-sitosterol for 48 h. Cell viability was measured via CCK-8 assay.

  • 1/16

    Beta-Sitosterol (purity>80%) purchased from MedChemExpress. Usage Cited in: Front Oncol. 2022 Aug 10;12:882784. [Abstract]

    Customer Validation
     Mice were administered β-sitosterol (75 mg/kg) each day via oral gavage. Nude mice were subcutaneously injected with MDA-MB-231 cells. Representative images showed the dissected tumors in distinct treatment groups as specified at the endpoint.

  • 1/16

    Beta-Sitosterol (purity>80%) purchased from MedChemExpress. Usage Cited in: Front Oncol. 2022 Aug 10;12:882784. [Abstract]

    Customer Validation
     Mice were administered β-sitosterol (75 mg/kg) each day via oral gavage. Tumor lysates were collected, and the protein profile was established by immunoblotting analysis.

  • 1/16

    Beta-Sitosterol (purity>80%) purchased from MedChemExpress. Usage Cited in: Biosci Rep. 2020 Oct 30;40(10):BSR20201349. [Abstract]

    Customer Validation
     Beta-sitosterol (5–100 μM; 48 h). Different concentrations of active compounds on improvement rate.

  • 1/16

    Beta-Sitosterol (purity>80%) purchased from MedChemExpress. Usage Cited in: Biosci Rep. 2020 Oct 30;40(10):BSR20201349. [Abstract]

    Customer Validation
     Beta-Sitosterol (40 μM; 30 min) reduced IL-6 concentration.

  • Beta-Sitosterol (purity>80%)