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Art. -Nr.: HY-15581S

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MMAD-d₈

(Synonyms: Demethyldolastatin 10-d₈; Monomethylauristatin D-d₈; Monomethyl Dolastatin 10-d₈)

Kundenbewertung

Based on 1 Customer Validation

MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.95%
Formel: C₄₁H₅₈D₈N₆O₆S
Molecular Weight:779.11

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years

* The compound is unstable in solutions, freshly prepared is recommended.

MMAD-d₈ Chemical Structure

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Anwendung
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

IC₅₀ & Target

Auristatin

Alle ADC Payloads Isoform-spezifische Produkte anzeigen :

In Vitro

MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 203849-91-6
Appearance Solid
Molecular Weight 779.11
Formel C₄₁H₅₈D₈N₆O₆S
Color White to off-white
SMILES

O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@@H](OC)[C@H]3N(C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@](C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])([2H])NC([C@H](C(C)C)NC)=O)=O)C)=O)CCC3
Synonyms

Demethyldolastatin 10-d₈; Monomethylauristatin D-d₈; Monomethyl Dolastatin 10-d₈
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years

* The compound is unstable in solutions, freshly prepared is recommended.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (128.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.2835 mL

6.4176 mL

12.8352 mL

5 mM

0.2567 mL

1.2835 mL

2.5670 mL

10 mM

0.1284 mL

0.6418 mL

1.2835 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.2835 mL	6.4176 mL	12.8352 mL	32.0879 mL
	5 mM	0.2567 mL	1.2835 mL	2.5670 mL	6.4176 mL
	10 mM	0.1284 mL	0.6418 mL	1.2835 mL	3.2088 mL
	15 mM	0.0856 mL	0.4278 mL	0.8557 mL	2.1392 mL
	20 mM	0.0642 mL	0.3209 mL	0.6418 mL	1.6044 mL
	25 mM	0.0513 mL	0.2567 mL	0.5134 mL	1.2835 mL
	30 mM	0.0428 mL	0.2139 mL	0.4278 mL	1.0696 mL
	40 mM	0.0321 mL	0.1604 mL	0.3209 mL	0.8022 mL
	50 mM	0.0257 mL	0.1284 mL	0.2567 mL	0.6418 mL
	60 mM	0.0214 mL	0.1070 mL	0.2139 mL	0.5348 mL
	80 mM	0.0160 mL	0.0802 mL	0.1604 mL	0.4011 mL
	100 mM	0.0128 mL	0.0642 mL	0.1284 mL	0.3209 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Anwendung
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Menge:
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MMAD-d8

Alle ADC Payloads Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MMAD-d8 Related Classifications

HY-15581S Related Classifications

MMAD-d₈

MMAD-d₈ Related Classifications