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Mdivi-1

(Synonyms: Mitochondrial division inhibitor 1)
346 Cited Publications
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Based on 346 publication(s) in Google Scholar

Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor.

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  • Reinheit: 99.96%
  • CAS. Nr.: 338967-87-6
  • Formel: C15H10Cl2N2O2S
  • Molecular Weight:353.22
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Mdivi-1 Chemical Structure
    Mdivi-1 Chemical Structure
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
  • Experimental Validation Results for Mdivi-1
CAS. Nr.: 338967-87-6
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  • Mdivi-1 Chemical Structure
    Mdivi-1 Chemical Structure
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    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 26;13(1):18. [Abstract]

    Customer Validation
     Effect of Mdivi-1 (250 nM; 200 μM) on the proliferation of MC3T3-E1 cells was determined by CCK-8 assay after 2 days of stimulation.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 26;13(1):18. [Abstract]

    Customer Validation
     IF staining of BNIP3, NIX, and DRP1 expression in MC3T3-E1 cells treated with DEX and Mdivi1 (5 μM). Scale bar = 50 μm.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 26;13(1):18. [Abstract]

    Customer Validation
     WB analysis of BNIP3, NIX, DRP1, MFN1 and MFN2 expression in MC3T3-E1 cells treated with DEX and Mdivi1 (5 μM).

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 26;13(1):18. [Abstract]

    Customer Validation
     The evaluation MMP was performed using JC-1 staining following DEX and Mdivi1 (5 μM) intervention. Scale bar = 200 μm.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Jun;21(6):1228-1244. [Abstract]

    Customer Validation
     Mdivi-1 (20 μM) significantly inhibits the S. Typhimurium infection-induced colocalization of mitochondria (labeled by TIMM23) with the autophagy marker LC3B in RAW264.7 cells, indicating that it blocked the occurrence of mitophagy.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Jun;21(6):1228-1244. [Abstract]

    Customer Validation
     Mdivi-1 (50 mg/kg/day; i.p.;Mice infected with S. Typhimurium for 5 consecutive days ). Representative histologicalexaminations and pathological tubular injury scores were performed by H-E staining in mice infected with S. Typhimurium and S.T-ΔSseJ strains and treated withdifferent drugs.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Jan 23:80:103511. [Abstract]

    Customer Validation
     Mdivi-1 (10 mg/kg; i.p.; single dose) inhibits the NRG-1 postconditioning-induced increase in LC3B fluorescence intensity in rat myocardial tissue.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Dec 27:79:103471. [Abstract]

    Customer Validation
     Cell viability assayed by cellular CCK8 activity of NMCMs subjected to H/R with or without Mdixi-1 or FCCP.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Jan 23:80:103511. [Abstract]

    Customer Validation
     Mdivi-1 (10 mg/kg; i.p.; single dose) significantly reduces the NRG-1 postconditioning-induced PINK1 protein expression in rat myocardial tissue.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Dec 27:79:103471. [Abstract]

    Customer Validation
     Mdivi-1 (5 μM). Representative images and statistical data of MMP in NMCMs. Scale bar, 75 μm.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Feb 4;23(1):156. [Abstract]

    Customer Validation
     Flow cytometry analysis of the impact of Mdivi-1 (20µM) pretreatment, with or without added IL10 (1ng/ml), on the bacterial load of BMDMs infected with GFP-S. aureus (MOI = 10) for 24 h. Quantitative analysis of the proportion of BMDMs infected with GFP-S. aureus.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Feb 4;23(1):156. [Abstract]

    Customer Validation
     Flow cytometry analysis of mtROS levels in BMDMs 24 h after infection with S. aureus (MOI = 10) in various treatment groups. Quantitative analysis of intracellular mtROS levels (IL-10:1 ng/mL, 24 h,Mdivi-1:20 µM, 24 h).

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 16;15(1):8927. [Abstract]

    Customer Validation
     Immunoblot analysis of the lysates of PDPK1-KO HEK293T cells transfected with the indicated vectors in the presence or absence of Mdivi-1 (2.5 μM; 4 h), CQ (50 μM; 4 h) or wortmannin (Wor.) (5 μM; 4 h) (n = 3 biological replicates).

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Jan;21(1):102-119. [Abstract]

    Customer Validation
     Mdivi-1 (25 μM; 6 h) treatment can rescue the degradation of exogenous and endogenous MAVS induced by SFTSV NP overexpression. 293T cells were co-transfected with Flag-MAVS (2 μg) along with HA-NP plasmid (2 μg) or empty vector (pCAGGS) for 20 h and then treated with Mdivi-1 (25 μM) or vehicle (DMSO) for 6 h. The cell lysates were analyzed with western blot.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Jan;21(1):102-119. [Abstract]

    Customer Validation
     Mdivi-1 (25 μM; 6 h) treatment can rescue the degradation of exogenous and endogenous MAVS induced by SFTSV NP overexpression. 293T cells were co-transfected with HA-NP plasmid (2 μg) or empty vector (pCAGGS) for 20 h and then treated with Mdivi-1 (25 μM) or vehicle (DMSO) for 6 h. The cell lysates were analyzed with western blot.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Jan;21(1):102-119. [Abstract]

    Customer Validation
     Mdivi-1 (10-25 μM; 24  h) reduces intracellular SFTSV S, M, and L segments mRNA levels in infected HeLa cells.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Aug 3:S2090-1232(24)00326-6. [Abstract]

    Customer Validation
     Mdivi-1 (10 μM) increases the expression of TNF-α and IL-1β

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Aug 3:S2090-1232(24)00326-6. [Abstract]

    Customer Validation
     Western blot analysis of the cytoplasmic and nuclear proteins in BV2 cells treated with CCCP or Mdivi-1.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Aug 3:S2090-1232(24)00326-6. [Abstract]

    Customer Validation
     N2A cells were treated with conditional medium derived from HSV-1 infected BV2 cells with or without CCCP or Mdivi-1 for 24 h and cell viability was examined.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Small. 2023 Aug;19(33):e2301497. [Abstract]

    Customer Validation
     Effect of different treatment combinations, including nMIL-100(Fe) (12.5 µg/mL, 48 h), RGD-nMIL-100(Fe) (12.5 µg/mL, 48 h), β-Lap (1.0 × 10−6 m, 4 h) and Mdivi-1(10 × 10−6 m, 1 h) pretreatment on KLE and AN3CA cell viability.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2023 Jun:62:102663. [Abstract]

    Customer Validation
     The effect of Mdivi-1 (50 μM) on α-KG activity in human chondrocytes. The protein expression of MMP13, IL-6, and TNF-α were determined by western blot.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2023 Jun:62:102663. [Abstract]

    Customer Validation
     The effect of Mdivi-1 (50 μM) on the activity of α-KG in human chondrocytes. IF was used to determine protein expression of COL2A1, scale bar = 25 μm, n=3.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2023 Jun:62:102663. [Abstract]

    Customer Validation
     The effect of Mdivi-1 (50 μM) on α-KG activity in human chondrocytes. RT-qPCR was used to determine the mRNA expression of PINK1.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Vet Microbiol. 2023 May:280:109697. [Abstract]

    Customer Validation
     S.aureus-induced reduction of mitochondrial proteins is blocked by Mdivi-1 (20 μM; 2 h) in BMECs.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Autophagy. 2021 Nov;17(11):3592-3606. [Abstract]

    Customer Validation
     Effect of Mdivi-1 on CBD-induced mitophagy in glioma cells. U251 cells were pretreated with mdivi-1 (2.5 μM) for 1 h and then treated with CBD (20 μM) for 24 h. Mitophagy induction was evaluated by immunoblotting of PINK1, PRKN, LC3, TOMM20, and COX4I1.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2022 Feb 15;424(Pt A):127268. [Abstract]

    Customer Validation
     Mdivi-1 (25 mg/kg, i.p.) significantly reduces the levels of apoptosis-related proteins (including C-Casp3 and C-PARP) in the placentas of Cd-exposed CD-1 mice.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2022 Feb 15;424(Pt A):127268. [Abstract]

    Customer Validation
     Mdivi-1 (5 μM; 1 h) rescues environmental cadmium-induced apoptosis in human primary trophoblasts by decreasing C-Casp3 levels.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Jan 1;11(2):522-539. [Abstract]

    Customer Validation
     Mdivi-1 (1.2 mg/kg; i.v. injection 30 min before SAH) reduces DHE- and TUNEL-positive cells in the SAH+PGC-1α siRNA+Mdivi-1 group when compared with the SAH + PGC-1α group.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Theranostics. 2019 Feb 28;9(6):1698-1713. [Abstract]

    Customer Validation
     Western blotting of SDs and markers of podocyte dedifferentiation with the treatment of PA , BBR + PA and Mdivi1+PA.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Mar 8;10(3):232. [Abstract]

    Customer Validation
     HepG2/ADM cells are pretreated with mdivi-1 (10 μM) for 1 h, followed by treatment with B5G1 (6 μM) for another 24 h. Mitochondrial colocalization with LC3 is detected by immunofluorescence.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Mar 8;10(3):232. [Abstract]

    Customer Validation
     HepG2/ADM cells are pretreated with mdivi-1 (10 μM) for 1 h, followed by treatment with B5G1 (6 μM) for another 48 h. Apoptosis-related proteins expression level is detected by western blotting. β-actin was used as a loading control.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Brain Res. 2019 May 15:1711:68-76. [Abstract]

    Customer Validation
     Levels of CytC in cytosol (Cyto-CytC), CytC in mitochondria (Mito- CytC) and cleaved caspase-3 in hippocampus are determined by western blot with the treatment of sham, HIR, MDV or FK506.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: J Pineal Res. 2018 Sep;65(2):e12491. [Abstract]

    Customer Validation
     Inhibition of mitochondrial fission with mdivi-1 or Drp1 siRNA suppresses hyperglycemia-induced oxidative stress. Protein expression of Nox4.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Transl Res. 2018 Apr:194:68-78. [Abstract]

    Customer Validation
     Representative western blot analysis of pDrp1-616 and total Drp1 protein expression in the hippocampus (left). Tubulin is used as the loading control. Protein expressions are quantified by western blot band intensity (right).

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2017 Nov:112:336-349. [Abstract]

    Customer Validation
     Mdivi-1 administration reduces NF-κB-dependent inflammation. A. Western blot assay and quantitative analysis of Cyto-p65 (A) and Nec-p65 (B) expression. ß-actin and H3 are used as internal controls of cytosolic and nuclear subfractions, respectively.

  • 1/16

    Mdivi-1 purchased from MedChemExpress. Usage Cited in: Exp Neurol. 2017 Sep:295:116-124. [Abstract]

    Customer Validation
     Mdivi-1 treatment inhibits the expression of DRP1, alleviates ROS and reduces the expression of NLRP3 and cleaved caspase-1 at 24 h after SAH. Representative Western blots showing levels of DRP1.

  • Mdivi-1