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Art. -Nr.: HY-149811

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AcrB-IN-3

Efflux pump-IN-3 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-3 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-3 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model.

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CAS. Nr.: 2890177-94-1
Formel: C₃₀H₃₃NO₇
Molecular Weight:519.59

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AcrB-IN-3 Chemical Structure

CAS. Nr.: 2890177-94-1

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
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Beschreibung

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In Vitro

Efflux pump-IN-3 (compound G10) (8-128 μg/mL) shows outstanding antibacterial synergism with at least one of the antibiotics (ERY, LEV and MIN). Efflux pump-IN-3 show antibacterial synergism with MIN, and reduces the MIC value of ERY by 4-fold at 64 μg/mL^[1].
Efflux pump-IN-3 (50 μM, 100 μM) shows strong inhibitory activity at the lowest concentration of 50 μM, to inhibit Nile Red efflux^[1].
Efflux pump-IN-3 (4-256 μg/mL) does not cause hemolysis of mice red blood cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Efflux pump-IN-3 (compound G10) (128 μg/mL; 72 h) shows no significant and in vivo toxicity against Caenorhabditis elegans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2890177-94-1
Molecular Weight 519.59
Formel C₃₀H₃₃NO₇
SMILES

O=C(C1=CC(OCCCOC2=CC=CC3=C2C=C(C(N4CCOCC4)=O)C5=C3OC(C)(CC5)C)=CC=C1)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Guo T, et al. Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance. Eur J Med Chem. 2023 Mar 5;249:115148. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vivo
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AcrB-IN-3

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Biologische Aktivität

Chemical Information

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AcrB-IN-3 Related Classifications

HY-149811 Related Classifications