Art. -Nr.: HY-N6929

Angelic acid

1 Cited Publications

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Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity.

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Reinheit: 99.20%
CAS. Nr.: 565-63-9
Formel: C₅H₈O₂
Molecular Weight:100.12

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Angelic acid Chemical Structure

CAS. Nr.: 565-63-9

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Angelic acid (200 μM; 24 h) synergistically inhibits the cell viability and cell proliferation of DLD1 and SW480 colorectal cancer cells with RSL3 (2 μM)^[1].
Angelic acid (200 μM; 24 h) upregulates the mRNA expression of ferroptosis-related genes CHAC1 and PTGS2 in DLD1 cells, reduces the protein level of NRF2, and increases K48 ubiquitination modification^[1].
Angelic acid (5-15 μM; 6 h pretreatment + UVA irradiation) significantly reduces the level of intracellular reactive oxygen species induced by UVA in the ROS detection experiment of normal human dermal fibroblasts (NHDFs), restores the GSH content, and upregulates the gene expression of antioxidant enzymes such as GPx1, SOD1/2, and CAT^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Angelic acid (8 mg/kg; intraperitoneal injection; once every 2 days; 20 days) synergistically inhibits tumor growth in the CT26 colorectal cancer subcutaneous xenograft model in Balb/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Balb/c mice with CT26 colorectal cancer subcutaneous xenograft model^[1]
Dosage:

8 mg/kg with or without Sulfasalazine 10 mg/kg
Administration:

Intraperitoneal injection, every 2 days, for a total 20 days
Result:

Combination treatment significantly retarded tumor growth compared to single-agent therapy (tumor volume inhibition rate: Combination group > Angelic acid group > Sulfasalazine group).
No significant changes in body weight were observed across groups, and H&E staining of major organs (heart, liver, spleen, lung, kidney) showed no pathological abnormalities, indicating no severe systemic toxicity.
Tumor tissues from the combination group exhibited enhanced lipid peroxidation and reduced NRF2 expression compared to controls.

Chemical Information

CAS. Nr. 565-63-9
Appearance Solid
Molecular Weight 100.12
Formel C₅H₈O₂
Color White to off-white
SMILES

C/C=C(C)\C(O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Plants
- Umbelliferae
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Res Sq

2026 Jan 30.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 200 mg/mL (1997.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

9.9880 mL

49.9401 mL

99.8801 mL

5 mM

1.9976 mL

9.9880 mL

19.9760 mL

10 mM

0.9988 mL

4.9940 mL

9.9880 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (49.94 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (49.94 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (49.94 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cao Y, et al. Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability. J Nat Med. 2025 Jan;79(1):82-94. [Content Brief]

[2]. Jung-Eun Ku. Photodamage attenuation effect by angelic acid in UVA irradiation-induced damages in normal human dermal fibroblast. Biomedical Dermatologyvolume 2, Article number: 8 (2018).

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	9.9880 mL	49.9401 mL	99.8801 mL	249.7004 mL
	5 mM	1.9976 mL	9.9880 mL	19.9760 mL	49.9401 mL
	10 mM	0.9988 mL	4.9940 mL	9.9880 mL	24.9700 mL
	15 mM	0.6659 mL	3.3293 mL	6.6587 mL	16.6467 mL
	20 mM	0.4994 mL	2.4970 mL	4.9940 mL	12.4850 mL
	25 mM	0.3995 mL	1.9976 mL	3.9952 mL	9.9880 mL
	30 mM	0.3329 mL	1.6647 mL	3.3293 mL	8.3233 mL
	40 mM	0.2497 mL	1.2485 mL	2.4970 mL	6.2425 mL
	50 mM	0.1998 mL	0.9988 mL	1.9976 mL	4.9940 mL
	60 mM	0.1665 mL	0.8323 mL	1.6647 mL	4.1617 mL
	80 mM	0.1249 mL	0.6243 mL	1.2485 mL	3.1213 mL
	100 mM	0.0999 mL	0.4994 mL	0.9988 mL	2.4970 mL

Keywords

Angelic acid

1 Cited Publications

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Angelic acid

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Publications Citing Use of MedChemExpress (MCE) Angelic acid

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Angelic acid Related Classifications

HY-N6929 Related Classifications