Antimalarial agent 12
Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC50=155 nM), 3D7 strain (EC50=136 nM). Antimalarial agent 12 has CC50 values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli.
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- CAS. Nr.: 2715225-58-2
- Formel: C26H18BrClN2O2
- Molecular Weight:505.79
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
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Plasmodium |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>50000 nM
Compound: (R)-3b
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Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based fluorescence assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based fluorescence assay
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[PMID: 35300082] |
| Hepatocyte | CC50 |
>10000 nM
Compound: (R)-3b
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Cytotoxicity against human primary hepatocytes assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based fluorescence assay
Cytotoxicity against human primary hepatocytes assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based fluorescence assay
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[PMID: 35300082] |
Chemical Information
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CAS. Nr. 2715225-58-2
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Molecular Weight 505.79
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Formel C26H18BrClN2O2
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SMILES
O=C(C1=CC2=CC(Br)=CC=C2O1)N([C@@H]3C4=CC=C(Cl)C=C4)CCC5=C3NC6=C5C=CC=C6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antimalarial agent 12 Related Classifications
HY-143487 Related Classifications
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