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Art. -Nr.: HY-149938

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Antimalarial agent 25

Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo.

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CAS. Nr.: 2944456-41-9
Formel: C₂₁H₁₈N₄O₃
Molecular Weight:374.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Antimalarial agent 25 Chemical Structure

CAS. Nr.: 2944456-41-9

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Bioz

Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	289.2 μM Compound: 8	Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay	[PMID: 37130472]
Vero	CC₅₀	400.6 μM Compound: 8	Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay	[PMID: 37130472]

In Vitro

Antimalarial agent 25 (compound 8) inhibits P. falciparum with IC₅₀ of 4.2 μM, while shows CC₅₀ on mammalian cells with CC50s of 289.2 μM (HepG2), and 400.6 μM (Vero), respectively^[1].
Antimalarial agent 25 (compound 8) (15.62-1000 μM; 2 h) shows hemolytic activity below 40% at concentrations from 15.6 to 250 μM in uninfected human erythrocytes^[1].
Antimalarial agent 25 (compound 8) (30-0.411 μg/mL; 48 h) causes morphological changes such as complete cytoplasmic degradation and loss of membrane integrity in the W2 strain of P. falciparum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

W2 strain of P. falciparum (CQ-resistant)
Concentration:

30 - 0.411 μg/mL
Incubation Time:

48 h
Result:

Presented completely degraded cytoplasm with loss of membrane integrity, dense cytoplasm with some possible undefined organelles in degenerating stage, and a possible deteriorated food vacuole.

In Vivo

Antimalarial agent 25 (compound 8) (30 mg/kg; po; once daily for 4 consecutive days) shows antimalarial activity in female albino swiss mice^[1]. Antimalarial agent 25 (300 mg/kg; po; single dose) shows no significant pathological changes and histopathological damage in female mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice infected with Plasmodium berghei ANKA^[1]
Dosage:

30 mg/kg
Administration:

Oral administration; for 4 consecutive days
Result:

Partly reduced P. berghei infection.
Parasitemia decreased by 33% on the seventh day (post-treatment).

Chemical Information

CAS. Nr. 2944456-41-9
Molecular Weight 374.39
Formel C₂₁H₁₈N₄O₃
SMILES

COC1=CC=C(C=C1)C2=CN(N=N2)CCNC3=CC(C4=CC=CC=C4C3=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Costa Souza RM, et al. Biological activity of 1,2,3-triazole-2-amino-1,4-naphthoquinone derivatives and their evaluation as therapeutic strategy for malaria control. Eur J Med Chem. 2023 Jul 5;255:115400. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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Antimalarial agent 25

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Antimalarial agent 25 Related Classifications

HY-149938 Related Classifications