Arbaprostil
Arbaprostil is an orally active PGE1 (HY-B0131) analog. Arbaprostil protects the gastrointestinal mucosa from stomach acid and other irritants, promotes healing rate of gastric ucler through the antisecretory effect.
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- CAS. Nr.: 55028-70-1
- Formel: C21H34O5
- Molecular Weight:366.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vivo
Arbaprostil (1-100 μg/kg, p.o., single dose) pH-dependently inhibits gastric secretion, promotes the gastric ucler healing (3-10 μg/kg, p.o., twice daily for 4 weeks) in Donryu rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rat[1]
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Dosage:1-100 μg/kg
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Administration:i.v., single dose
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Result:Increased secrection of HCO3+.
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Animal Model:Donryu rats[2]
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Dosage:1-100 μg/kg
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Administration:1-100 μg/kg, p.o. and i.d. (intraduodenally), single dose; 3-10 μg/kg, p.o., twice daily for 4 weeks
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Result:Inhibited the gastric secretion when intraduodenally administrated.
Increased the gastric secretion when orally administrated.
Accelerated the healing rate of gastric ucler.
Chemical Information
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CAS. Nr. 55028-70-1
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Molecular Weight 366.49
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Formel C21H34O5
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SMILES
CCCCC[C@@](O)(/C=C/[C@H]1[C@@H](CC([C@@H]1C/C=C\CCCC(O)=O)=O)O)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Li JY, Nagata T, Yoshida M, Yagi N, Katoh K, Haramoto T, Itoh K, Iwasaki A, Matsuo Y. Effect of 15(R)-15-methyl PGE2 (arbaprostil) on duodenal bicarbonate secretion in rat. Gastroenterol Jpn. 1989 Feb;24(1):8-11. [Content Brief]
[2]. Okabe S, et al., Effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in rats. Jpn J Pharmacol. 1986 Feb;40(2):329-37. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Arbaprostil Related Classifications
HY-129471 Related Classifications
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