Art. -Nr.: HY-P9952

Biologically Validated

Belimumab

Name: Belimumab
Brand: MedChemExpress
SKU: HY-P9952
Price: 72.00 USD
Availability: InStock
Rating: 5 (6 reviews)

(Synonyms: LymphoStat B)

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

Belimumab (LymphoStat B) is a human IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research. The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.4%
CAS. Nr.: 356547-88-1
Molecular Weight:144.54 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Belimumab Chemical Structure

CAS. Nr.: 356547-88-1

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Publications (6)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Belimumab (LymphoStat B) is a human IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research^[1]^[2]^[3]^[4]. The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.

Isotype

Human IgG1 lambda2

Recommend Isotype Controls

Human IgG1 lambda2, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

TNFSF13B/BAFF/CD257

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

Belimumab (5, 15 or 50 mg/kg, i.v., once every 2 weeks for 13 or 26 weeks) decreases CD20+ B lymphocytes in the peripheral blood in cynomolgus monkeys^[3].

Single-Dose Pharmacokinetics of i.v. Belimumab in Cynomolgus Monkeys^[3]

Parameters	C_max (μg/mL)	AUC_0-∞ (day μg/mL)	V₁ (mL/kg)	V_ss (mL/kg)	CL (mL/day/kg)	T_1/2,α (day)	T_1/2,term (day)	MRT (day)
5 mg/kg (n=4)	111±2	901±40	45.0±0.7	85.0±2.1	5.6±0.2	0.52±0.13	11.2±0.7	15.4±1.0
50 mg/kg (n=3)	1230±180	8970±320	42.4±5.9	108±14	5.6±0.2	0.44±0.20	14.0±1.8	19.1±2.1
150 mg/kg (n=3)	3778±326	22,693±3990	39.7±3.3	89.8±11.4	6.8±1.3	0.41±0.55	11.5±1.7	13.7±3.5

Pharmacokinetics of Belimumab after 4 times Weekly i.v. Doses in Male and Female Cynomolgus Monkeys^[3]

Parameters	C_max (μg/mL)	AUC_0-∞ (day μg/mL)	V₁ (mL/kg)	V_ss (mL/kg)	CL (mL/day/kg)	T_1/2,α (day)	T_1/2,term (day)	MRT (day)
5 mg/kg (n=4)	102±14	717±129	49.7±6.8	126±18	7.2±1.5	0.71±0.26	13.5±1.8	17.8±2.5
50 mg/kg (n=4)	313±38	2365±501	48.4±6.2	108±10	6.5±1.2	1.29±0.61	14.0±3.1	17.0±4.2
150 mg/kg (n=4)	1064±190	9286±1809	48.0±7.8	106±18	5.5±1.1	0.77±0.16	14.6±2.2	19.4±3.5

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Healthy cynomolgus monkeys^[3]
Dosage:

5, 15 or 50 mg/kg
Administration:

peripheral vein injection, once every 2 weeks for 13 or 26 weeks
Result:

Dose-dependently decreased circulating peripheral blood B lymphocytes persisted through at least week 39 and in some monkeys longer despite cessation of treatment at week 26.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

10673 [NCBI]

Accession

Q9Y275

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 lambda

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized BAFF/TNFSF13B Protein, Human (CHO, HY-P7003) can bind Belimumab. The EC₅₀ for this effect is 12 ng/mL.
Flow cytometric analysis of 1.5×10⁶ THP-1 cells with Belimumab (HY-P9952, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2 Isotype Control (HY-P990096, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

Chemical Information

CAS. Nr. 356547-88-1
Appearance Solid
Molecular Weight 144.54 kDa
Color White to off-white
SMILES

[Belimumab]
Synonyms

LymphoStat B
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (6)

All Flow Cytometry

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Leukemia

The bone marrow immune ecosystem shapes daratumumab acquired resistance in plasma cell myeloma. [Abstract]

2025 Aug 1. PMID: 40750676

Belimumab purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Aug 1. [Abstract]

Bone marrow mononuclear cells (BMMCs) from acquired resistant PCM patients were used in Dara-induced ADCC assays. CD138-positive plasma cells were quantified by flow cytometry. BMMCs were treated with Dara (5 or 10 μg/mL) ± inhibitors (Belimumab [BAFF], 4-IPP [MIF], and MYCi975 [MYC]) for 24 h, then co-cultured with NK-cells at an effector:target (E:T) ratio = 1:1 for 12 h. The amount of released LDH was determined using a cytotoxicity assay kit to calculate the % of lysed cells.
Biochim Biophys Acta Mol Basis Dis

2026 Nov;1872(8):168342. PMID: 42385863
Clin Immunol

NETosis promotes chronic inflammation and fibrosis in systemic lupus erythematosus and COVID-19. [Abstract]

2023 Sep:254:109687. PMID: 37419296
Immunopharmacol Immunotoxicol

Inhibition of long-lived plasma cells, a critical role for Telitacicept treatment to systemic lupus erythematosus. [Abstract]

2025 Jul 30:1-11. PMID: 40734465
Kaohsiung J Med Sci

TLR9 regulates the autophagy-lysosome pathway to promote dendritic cell maturation and activation by activating the TRAF6-cGAS-STING pathway. [Abstract]

2023 Dec;39(12):1200-1212. PMID: 37850718
bioRxiv

B-cell activating factor plays a critical role in CAR-T cell-associated cytokine release syndrome. [Abstract]

2025 Nov 25:2025.11.22.689920. PMID: 41404620

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Hannah A Blair, et al. Belimumab: A Review in Systemic Lupus Erythematosus. Drugs. 2018 Mar;78(3):355-366. [Content Brief]

[2]. Stohl W, et al. The discovery and development of belimumab: the anti-BLyS-lupus connection. Nat Biotechnol. 2012 Jan 9;30(1):69-77. [Content Brief]

[3]. Halpern WG, et al. Chronic administration of belimumab, a BLyS antagonist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys: pharmacokinetic, pharmacodynamic, and toxicologic effects. Toxicol Sci. 2006 Jun;91(2):586-99. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Belimumab

6 Cited Publications

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Belimumab

Publications Citing Use of MedChemExpress (MCE) Belimumab

Alle TNF Receptor Isoform-spezifische Produkte anzeigen