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Art. -Nr.: HY-184345

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(+)-Cyclozonarone

(+)-Cyclozonarone is a benzoquinone derivative found in brown algae Dictyopteris undulata, with activity against T. cruzi epimastigotes, Tulahuen strains. (+)-Cyclozonarone inhibits growth of cancer and endothelial cells, and exhibits anti-leishmanial activity. (+)-Cyclozonarone can be used for the research of lung carcinoma, colon carcinoma, prostate carcinoma.

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CAS. Nr.: 332858-46-5
Formel: C₂₁H₂₄O₂
Molecular Weight:308.41

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(+)-Cyclozonarone Chemical Structure

CAS. Nr.: 332858-46-5

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In Vitro

(+)-Cyclozonarone shows selective cytotoxicity toward MS-1 mouse endothelial cells with an IC₅₀ of 0.1-0.5 μg/mL, and has IC₅₀ values of 1-5 μg/mL for A-549 cells, 5 μg/mL for H-116 and PC-3 cells, and 1 μg/mL for HT-29 cells^[1].
(+)-Cyclozonarone potently inhibits the growth of T. cruzi Tulahuen strain epimastigotes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 332858-46-5
Molecular Weight 308.41
Formel C₂₁H₂₄O₂
SMILES

C[C@@]12C3=CC(C(C=CC4=O)=O)=C4C=C3CC[C@@]1([H])C(C)(CCC2)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Virginia Delgado, et al. Synthesis of racemic and chiral albicanol, albicanyl acetate and cyclozonarone: cytotoxic activity of ent-cyclozonarone. January 2008. Journal of the Brazilian Chemical Society. 19(7):1258-1263.

[2]. Wijeratne EM, et al. Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert. J Nat Prod. 2008 Feb;71(2):218-22. [Content Brief]

[3]. Rosales Martínez A, et al. Cp2TiCl-catalyzed, concise synthetic approach to marine natural product (±)-cyclozonarone. Synthetic Communications, 49(19), 2554-2560.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Konzentration Konzentration

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Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(+)-Cyclozonarone

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(+)-Cyclozonarone Related Classifications

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