D-Serine-d3
Based on 1 Customer Validation
D-Serine-d3 ((R)-Serine-d3) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.
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- Reinheit: 99%
- CAS. Nr.: 1414348-52-9
- Formel: C3H4D3NO3
- Molecular Weight:108.11
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Speicherung:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1414348-52-9
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Unlabeled Cas 312-84-5
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Appearance Solid
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Molecular Weight 108.11
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Formel C3H4D3NO3
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Color White to off-white
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SMILES
OC([C@@](N)([2H])C([2H])([2H])O)=O
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Synonyms
(R)-Serine-d3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Lösungsmittel & Löslichkeit
H2O : 50 mg/mL (462.49 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [Content Brief]
[2]. Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.
[3]. MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression Front Psychiatry. 2019 Feb 6;10:25. [Content Brief]
[4]. Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986. [Content Brief]
[5]. Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.2498 mL | 46.2492 mL | 92.4984 mL | 231.2460 mL |
| 5 mM | 1.8500 mL | 9.2498 mL | 18.4997 mL | 46.2492 mL | |
| 10 mM | 0.9250 mL | 4.6249 mL | 9.2498 mL | 23.1246 mL | |
| 15 mM | 0.6167 mL | 3.0833 mL | 6.1666 mL | 15.4164 mL | |
| 20 mM | 0.4625 mL | 2.3125 mL | 4.6249 mL | 11.5623 mL | |
| 25 mM | 0.3700 mL | 1.8500 mL | 3.6999 mL | 9.2498 mL | |
| 30 mM | 0.3083 mL | 1.5416 mL | 3.0833 mL | 7.7082 mL | |
| 40 mM | 0.2312 mL | 1.1562 mL | 2.3125 mL | 5.7811 mL | |
| 50 mM | 0.1850 mL | 0.9250 mL | 1.8500 mL | 4.6249 mL | |
| 60 mM | 0.1542 mL | 0.7708 mL | 1.5416 mL | 3.8541 mL | |
| 80 mM | 0.1156 mL | 0.5781 mL | 1.1562 mL | 2.8906 mL | |
| 100 mM | 0.0925 mL | 0.4625 mL | 0.9250 mL | 2.3125 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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