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Art. -Nr.: HY-121398

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Dipivefrin

Dipivefrin is an α/β-adrenoceptor agonist and a prodrug of epinephrine. Dipivefrin regulates intraocular pressure by agonizing α/β-adrenoceptors and modulating the aqueous humor outflow pathway. Dipivefrin acts on neuroblastoma cells and downregulates glutamate-induced intracellular calcium levels. Dipivefrin is used in research related to α/β-adrenoceptor-mediated diseases, such as glaucoma.

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CAS. Nr.: 52365-63-6
Formel: C₁₉H₂₉NO₅
Molecular Weight:351.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Dipivefrin Chemical Structure

CAS. Nr.: 52365-63-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Protokoll (2)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

α adrenergic receptor

β adrenergic receptor

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Dipivefrin (2.8-280 μM; 100 min) significantly inhibits the proliferation of cultured human corneal stromal cells only at a high concentration of 280 μM^[3].
Dipivefrin (0.28-28 mM; 100 seconds) dose-dependently inhibits glutamate-induced elevation of [Ca²⁺]_i and decreases basal [Ca²⁺]_i in cultured N1E-115 neuroblastoma cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

Dipivefrin hydrochloride (3 μL of 0.1%; topical ocular; single dose) exhibits a significant intraocular pressure-lowering effect in ddY mice^[1].
Dipivefrin (10 µg/kg; i.p.; before memory retrieval) administered before memory retrieval enhances the ability of alcohol-associated light cues to serve as conditioned reinforcers, indicating bidirectional modulation of alcohol memory reconsolidation through enhanced central adrenergic signaling^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 52365-63-6
Molecular Weight 351.44
Formel C₁₉H₂₉NO₅
SMILES

CC(C)(C(OC1=CC=C(C=C1OC(C(C)(C)C)=O)C(CNC)O)=O)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Signal Pathway Related Cell Biology

Calcium Spark Assay
Calcium sparks are localized, transient increases in intracellular calcium concentration ([Ca²⁺]i) that occur in cardiac myocytes and represent elementary events underlying excitation-contraction coupling. These events are generated by the coordinated opening of clusters of ryanodine receptors (RyRs) on the sarcoplasmic reticulum membrane, leading to a brief release of Ca²⁺ into the cytosol. The detection and analysis of calcium sparks provide insights into the mechanisms of calcium handling and signaling in cardiac cells. Imaging techniques using fluorescent calcium indicators such as Fluo-3 are employed to visualize these subcellular calcium transients with high spatial and temporal resolution. The protocol is based on established methodologies described in primary literature for both experimental measurement and automated analysis of calcium sparks.
Ca²⁺ Staining Technique
Ca²⁺ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca²⁺ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Akaishi T, et al. Ocular hypotensive effects of anti-glaucoma agents in mice. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2009 Oct;25(5):401-8.

[2]. Barak S, et al. Targeting the Reconsolidation of Licit Drug Memories to Prevent Relapse: Focus on Alcohol and Nicotine. International journal of molecular sciences. 2021 Apr 15;22(8):4090.

[3]. Wu KY, et al. Effects of antiglaucoma drugs on cellular proliferation in cultured human corneal keratocytes. The Kaohsiung journal of medical sciences. 2006 Mar;22(3):120-5.

[4]. Hong SJ, et al. Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2003 Jun;19(3):205-15.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Protokoll
Reinheit & Dokumentation
Verweise

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Dipivefrin

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen