EphB1-IN-2
EphB1-IN-2 is a mutant-selective kinase inhibitor of ABL and FGFR4, with an IC50 of 14 nM against ABLG321C mutant and 163 nM against FGFR4G556C mutant. EphB1-IN-2 shows selectively over wild-type ABL and FGFR4.
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- CAS. Nr.: 2097512-73-5
- Formel: C17H15ClN4O2
- Molecular Weight:342.78
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Help & FAQs
Biologische Aktivität
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FGFR4 >10000 nM (IC50) |
EphB1-IN-2 (compound 10) shows 37-fold selective inhibition of ABLG321C over wild-type ABL, with IC50 values of 14 nM and 530 nM, respectively[2].
EphB1-IN-2 shows greater than 61-fold selective inhibition of FGFR4G556C over wild-type FGFR4, with an IC50 of 163 nM against FGFR4G556C and an IC50 greater than 10,000 nM against wild-type FGFR4[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2097512-73-5
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Molecular Weight 342.78
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Formel C17H15ClN4O2
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SMILES
O=C(CCl)NC1=CC2=NC=NC(NC3=CC(OC)=CC=C3)=C2C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
EphB1-IN-2 Related Classifications
HY-183909 Related Classifications
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