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Art. -Nr.: HY-150791

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FLDP-5

FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 cells.

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CAS. Nr.: 950665-12-0
Formel: C₂₁H₂₁NO₅
Molecular Weight:367.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

FLDP-5 Chemical Structure

CAS. Nr.: 950665-12-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
C6	IC₅₀	3.9 μM Compound: 14	Antiproliferative activity against rat C6 cells after 72 hrs by MTT assay Antiproliferative activity against rat C6 cells after 72 hrs by MTT assay	[PMID: 20831222]
Caco-2	IC₅₀	0.2 μM Compound: 14	Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay	[PMID: 20831222]
HaCaT	IC₅₀	3 μM Compound: 14	Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay	[PMID: 20831222]
HT-22	IC₅₀	3.1 μM Compound: 14	Antiproliferative activity against mouse HT22 cells after 72 hrs by MTT assay Antiproliferative activity against mouse HT22 cells after 72 hrs by MTT assay	[PMID: 20831222]
NB-4	IC₅₀	0.4 μM Compound: 231	Cytotoxicity against human NB4 cells assessed as reduction in cell viability after 72 hrs by MTS assay Cytotoxicity against human NB4 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 24960549]
NIH3T3	IC₅₀	4.2 μM Compound: 14	Antiproliferative activity against BALB/c mouse 3T3 cells after 72 hrs by MTT assay Antiproliferative activity against BALB/c mouse 3T3 cells after 72 hrs by MTT assay	[PMID: 20831222]
SH-SY5Y	IC₅₀	2.1 μM Compound: 14	Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTT assay Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 20831222]

In Vitro

FLDP-5 (0-20 μM; 24 h) has cytotoxicity on human glioblastoma multiforme (GBM) LN-18 cells and HBEC-5i^[1].
FLDP-5 (2.5 μM; 0-6 h) induces superoxide and hydrogen peroxide in LN-18 cell death^[1].
FLDP-5 (2.5 μM; 0-4 h) induces DNA damage with a time-dependent manner in LN-18 cells^[1].
FLDP-5 (1.25 and 2.5 μM; 24 and 48 h) potentiates anti-migration effects in LN-18 cells^[1].
FLDP-5 (1.25 and 2.5 μM; 24 h) reduces the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner^[1].
FLDP-5 (0.625 and 1.25 μM; 24 h) induces arrest in S phase in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

LN-18 and HBEC-5i cells
Concentration:

0-20 μM
Incubation Time:

24 h
Result:

Exhibited cytotoxicity on human GBM LN-18 cells and HBEC-5i with IC₅₀s of 2.4 μM and 5.6 μM.

Cell Migration Assay ^[1]

Cell Line:

LN-18 cells
Concentration:

1.25 and 2.5 μM
Incubation Time:

24 and 48 h
Result:

Potentiated anti-migration effects in LN-18 cells with wound closure of 56.43% ± 6.28 and 3.17% ± 0.71 at 1.25 μM and 2.5 μM (48 h), respectively.

Cell Invasion Assay^[1]

Cell Line:

LN-18 cells
Concentration:

1.25 and 2.5 μM
Incubation Time:

24 h
Result:

Reduced the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:

LN-18 cells
Concentration:

0.625 and 1.25 μM
Incubation Time:

24 h
Result:

Induced arrest in S phase in a concentration-dependent manner, and exhibited accumulation of 63.38% ± 4.42 at 1.25 μM.

Chemical Information

CAS. Nr. 950665-12-0
Molecular Weight 367.40
Formel C₂₁H₂₁NO₅
SMILES

O=C1/C(CNC/C1=C\C2=CC=C(O)C(OC)=C2)=C/C3=CC=C(O)C(OC)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Razali NSC, et al. Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells. Sci Rep. 2022 Jul 30;12(1):13131. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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FLDP-5

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

FLDP-5 Related Classifications

HY-150791 Related Classifications