Foscarnet sodium
Based on 3 publication(s) in Google Scholar
Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis.
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- Reinheit: 98.0%
- CAS. Nr.: 63585-09-1
- Formel: CNa3O5P
- Molecular Weight:191.95
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Foscarnet sodium
MoreAlle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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DNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEL | IC50 |
15.5 μM
Compound: phosphonoformate
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Inhibition of human CMV DNA synthesis in CMV-infected HEL cells.
Inhibition of human CMV DNA synthesis in CMV-infected HEL cells.
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[PMID: 7752205] |
| HFF | IC50 |
>100 μM
Compound: Foscarnet sodium
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Compound was evaluated for the visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration
Compound was evaluated for the visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration
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[PMID: 7562945] |
| Vero | ED50 |
>5000 μM
Compound: Foscarnet sodium
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Compound was tested for antiviral activity against vaccinia
Compound was tested for antiviral activity against vaccinia
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[PMID: 3016264] |
| Vero | ED50 |
170 μM
Compound: Foscarnet sodium
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Compound was tested for antiviral activity against Herpes simplex virus type 1(KOS)
Compound was tested for antiviral activity against Herpes simplex virus type 1(KOS)
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[PMID: 3016264] |
| Vero | ED50 |
20 μM
Compound: Foscarnet sodium
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Compound was tested for antiviral activity against Herpes simplex virus type 2 of strain 333
Compound was tested for antiviral activity against Herpes simplex virus type 2 of strain 333
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[PMID: 3016264] |
| Vero | ED50 |
230 μM
Compound: Foscarnet sodium
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Compound was tested for antiviral activity against Herpes simplex virus type 1 (HF)
Compound was tested for antiviral activity against Herpes simplex virus type 1 (HF)
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[PMID: 3016264] |
| Vero | ED50 |
89 μM
Compound: Foscarnet sodium
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Compound was tested for antiviral activity against Herpes simplex virus type 2 (MS)
Compound was tested for antiviral activity against Herpes simplex virus type 2 (MS)
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[PMID: 3016264] |
| Vero | ED50 |
>5000 μM
Compound: Foscarnet sodium
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Compound was tested for antiviral activity against measles virus
Compound was tested for antiviral activity against measles virus
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[PMID: 3016264] |
| Vero | ED50 |
5 mM
Compound: Foscarnet sodium
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Compound was tested for antiviral activity against para 3
Compound was tested for antiviral activity against para 3
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[PMID: 3016264] |
Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM),HSV-1, several strains (IC50=0.4-3.5 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 63585-09-1
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Appearance Solid
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Molecular Weight 191.95
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Formel CNa3O5P
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Color White to off-white
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SMILES
O=P(O[Na])(O[Na])C(O[Na])=O
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Synonyms
Trisodium phosphonoformate; Phosphonoformic acid trisodium salt
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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J Med Virol
2023 Jan;95(1):e28352. PMID: 36437481 -
Antiviral Res
Generation of a panel of mutants that are resistant to standard of care therapies in a clinically relevant strain of human cytomegalovirus for drug resistance profiling. [Abstract]2025 Sep:241:106237. PMID: 40653174 -
Viruses
Role of PARP-1 in Human Cytomegalovirus Infection and Functional Partners Encoded by This Virus. [Abstract]2022 Sep 15;14(9):2049. PMID: 36146855
Lösungsmittel & Löslichkeit
H2O : 16.67 mg/mL (86.85 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
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- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. [Content Brief]
[2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415. [Content Brief]
[3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.2097 mL | 26.0485 mL | 52.0969 mL | 130.2423 mL |
| 5 mM | 1.0419 mL | 5.2097 mL | 10.4194 mL | 26.0485 mL | |
| 10 mM | 0.5210 mL | 2.6048 mL | 5.2097 mL | 13.0242 mL | |
| 15 mM | 0.3473 mL | 1.7366 mL | 3.4731 mL | 8.6828 mL | |
| 20 mM | 0.2605 mL | 1.3024 mL | 2.6048 mL | 6.5121 mL | |
| 25 mM | 0.2084 mL | 1.0419 mL | 2.0839 mL | 5.2097 mL | |
| 30 mM | 0.1737 mL | 0.8683 mL | 1.7366 mL | 4.3414 mL | |
| 40 mM | 0.1302 mL | 0.6512 mL | 1.3024 mL | 3.2561 mL | |
| 50 mM | 0.1042 mL | 0.5210 mL | 1.0419 mL | 2.6048 mL | |
| 60 mM | 0.0868 mL | 0.4341 mL | 0.8683 mL | 2.1707 mL | |
| 80 mM | 0.0651 mL | 0.3256 mL | 0.6512 mL | 1.6280 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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