Eef2 - eukaryotic translation elongation factor 2 Gene

Also Known as Ef-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13629

Summary

Enables GTPase activity. Acts upstream of or within hematopoietic progenitor cell differentiation and translational elongation. Located in cytoplasm. Part of polysome. Is active in synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in glaucoma and spinocerebellar ataxia type 26. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Eef2 Products (1)

mRNA Protein Name
NM_007907.2 NP_031933.1 elongation factor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables GTPase activity IDA
IDA: Inferred from direct assay
22157746 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22157746 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24029230 MGI
acts upstream of or within translational elongation IDA
IDA: Inferred from direct assay
22157746 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12426392 MGI
NOT located in nucleus IDA
IDA: Inferred from direct assay
12426392 MGI
located in ribosome IDA
IDA: Inferred from direct assay
22157746 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16452087 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16452087 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

elongation factor 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-117684 Cabamiquine Inhibitor 99.61% Phase 2

Pre-clinical Phase

Bioactive Molecules (20)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-110096 A-484954 Inhibitor 99.57% Unkown
HY-124447 BTYNB 98.0% Unkown
HY-100576 NH125 Inhibitor 99.63% Unkown
HY-126396 Sordarin sodium Inhibitor 99.0% Unkown
HY-146324 PROTAC eEF2K degrader-1 Activator 98.64% Unkown
HY-117684A Cabamiquine succinate Inhibitor 99.80% Unkown
HY-120904 AMPK-IN-1 Activator 95.19% Unkown
HY-112393 TX-1918 Inhibitor / Unkown
HY-121828 TX-1123 Inhibitor / Unkown
HY-123024 Cefatrizine / Unkown
HY-176149 Fluoxetine-Conjugated Platinum(IV) prodrug-1 / Unkown
HY-177720 eEF2K degrader-2 / Unkown
HY-181506 TYMJ-01 / Unkown
HY-184950 eEF2K ligand-1 Ligand / Unkown
HY-RS04180 EEF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04181 EEF2K Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20013 Eef2k Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20725 Eef2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26516 Eef2k Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27237 Eef2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eef2 NCBI NCBI:1938