MAFF - MAF bZIP transcription factor F Gene

Also Known as U-MAF; hMafF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23764

About MAFF

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,201,994-38,216,511 (from NCBI)

This gene has 8 transcripts (splice variants), 190 orthologues and 6 paralogues. Ubiquitous expression in gall bladder (RPKM 22.1), fat (RPKM 18.9) and 25 other tissues.

Summary

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the Oxytocin Receptor (OTR) gene and most likely heterodimerizes with Other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

MAFF Products (4)

mRNA	Protein	Name
NM_001161572.2	NP_001155044.1	transcription factor MafF isoform a
NM_001161573.1	NP_001155045.1	transcription factor MafF isoform a
NM_001161574.2	NP_001155046.1	transcription factor MafF isoform b
NM_012323.4	NP_036455.1	transcription factor MafF isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12490281	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8932385	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12490281	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	23661758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAFF Protein Structure

bZIP_Maf

0
100
164 a.a.

Protein Preferred Names	Protein Names
transcription factor MafF	v-maf avian musculoaponeurotic fibrosarcoma oncogene family protein F

MAFF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MAFF	Q9ULX9	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	MAFF	Q9ULX9	NFE2L3	Homo sapiens	Q9Y4A8	FRET	23661758
Intra	MAFF	Q9ULX9	NFE2L3	Homo sapiens	Q9Y4A8	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	NFE2L3	Homo sapiens	Q9Y4A8	Anti Tag CoIP	28514442
Intra	MAFF	Q9ULX9	BACH1	Homo sapiens	O14867	FRET	23661758
Intra	MAFF	Q9ULX9	BACH2	Homo sapiens	Q9BYV9	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	BACH2	Homo sapiens	Q9BYV9	FRET	23661758
Intra	MAFF	Q9ULX9	BACH2	Homo sapiens	Q9BYV9	Anti Tag CoIP	28514442
Intra	MAFF	Q9ULX9	NFE2L2	Homo sapiens	Q16236	FRET	23661758
Intra	MAFF	Q9ULX9	NFE2L2	Homo sapiens	Q16236	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	NFE2L1	Homo sapiens	Q14494	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	NFE2L1	Homo sapiens	Q14494	FRET	23661758
Intra	MAFF	Q9ULX9	NFIL3	Homo sapiens	Q16649	FRET	23661758
Intra	MAFF	Q9ULX9	ATF3	Homo sapiens	P18847	FRET	23661758
Intra	MAFF	Q9ULX9	MAFG	Homo sapiens	O15525	FRET	23661758
Intra	MAFF	Q9ULX9	BATF2	Homo sapiens	Q8N1L9	FRET	23661758

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy	Autosomal Dominant Adult-Onset Proximal Sma Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type Finkel Disease Smafk Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant Autosomal Dominant Adult Proximal Spinal Muscular Atrophy Finkel Late-Adult Type Sma
Multicentric Carpotarsal Osteolysis Syndrome	Multicentric Carpo-Tarsal Osteolysis With Or Without Nephropathy MCTO Osteolysis, Hereditary, Of Carpal Bones With Or Without Nephropathy Idiopathic Multicentric Osteolysis With Or Without Nephropathy Autosomal Dominant Multicentric Osteolysis Hereditary Osteolysis Of Carpal Bones With Or Without Nephropathy Multicentric Osteolysis, Autosomal Dominant Multicentric Osteolysis Nephropathy Osteolysis, Carpotarsal, Multicentric Syndrome Lytic Lesion
Duane Retraction Syndrome	Stilling-Turk-Duane Syndrome Duane'S Syndrome Duane Syndrome Isolated Duane Retraction Syndrome Co-Contractive Retraction Syndrome Duane Anomaly, Isolated Ocular Retraction Syndrome Drs Durs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS07960	MAFF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18246	Maff Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24726	Maff Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAFF	VGNC	VGNC:31140
Macaca mulatta	MAFF	VGNC	VGNC:95357
Mus musculus	MAFF	MGD	MGI:96910
Rattus norvegicus	MAFF	RGD	RGD:1309531
Canis familiaris	MAFF	VGNC	VGNC:49919
Others	MAFF	NCBI