PNLIPRP1 - pancreatic lipase related protein 1 Gene

Also Known as PLRP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5407

About PNLIPRP1

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:116,590,959-116,609,175 (from NCBI)

This gene has 21 transcripts (splice variants), 136 orthologues and 9 paralogues. Restricted expression toward pancreas (RPKM 974.1).

Summary

Predicted to enable calcium ion binding activity. Predicted to be involved in lipid catabolic process. Predicted to be located in extracellular region. Biomarker of prostate Cancer. [provided by Alliance of Genome Resources, Apr 2022]

PNLIPRP1 Products (2)

mRNA Protein Name
NM_001303135.1 NP_001290064.1 inactive pancreatic lipase-related protein 1 precursor
NM_006229.4 NP_006220.1 inactive pancreatic lipase-related protein 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
NOT enables lipase activity IDA
IDA: Inferred from direct assay
19824014 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Verweise Source
NOT located in extracellular space IDA
IDA: Inferred from direct assay
19824014 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PNLIPRP1 Protein Structure

Lipase

Lipase: Lipase (18 - 353)

PLAT

PLAT: PLAT/LH2 domain (358 - 460)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 467 a.a.
Protein Preferred Names Protein Names

inactive pancreatic lipase-related protein 1

PNLIPRP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PNLIPRP1 P54315 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
PNLIPRP1 P54315 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
PNLIPRP1 P54315 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra
PNLIPRP1 P54315 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
PNLIPRP1 P54315 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 GDAP1 Homo sapiens Q8TB36
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 GDAP1 Homo sapiens Q8TB36
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 GDAP1 Homo sapiens Q8TB36
Y2H Array
32296183
Intra
PNLIPRP1 P54315 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 LRRC25 Homo sapiens Q8N386
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra
PNLIPRP1 P54315 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
PNLIPRP1 P54315 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 TMPPE Homo sapiens Q6ZT21
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 TMPPE Homo sapiens Q6ZT21
Y2H Array
32296183
Intra
PNLIPRP1 P54315 TMPPE Homo sapiens Q6ZT21
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra
PNLIPRP1 P54315 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 AQP2 Homo sapiens P41181
Y2H Array
32296183
Intra
PNLIPRP1 P54315 SLC34A2 Homo sapiens O95436-2
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 SLC34A2 Homo sapiens O95436-2
Y2H Array
32296183
Intra
PNLIPRP1 P54315 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra
PNLIPRP1 P54315 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
PNLIPRP1 P54315 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
PNLIPRP1 P54315 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
PNLIPRP1 P54315 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
PNLIPRP1 P54315 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
PNLIPRP1 P54315 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra
PNLIPRP1 P54315 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
PNLIPRP1 P54315 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
PNLIPRP1 P54315 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
PNLIPRP1 P54315 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
PNLIPRP1 P54315 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
PNLIPRP1 P54315 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
PNLIPRP1 P54315 BEST2 Homo sapiens Q8NFU1
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 BEST2 Homo sapiens Q8NFU1
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 BEST2 Homo sapiens Q8NFU1
Y2H Array
32296183
Intra
PNLIPRP1 P54315 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
PNLIPRP1 P54315 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 MCFD2 Homo sapiens Q8NI22
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 MCFD2 Homo sapiens Q8NI22
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 MCFD2 Homo sapiens Q8NI22
Y2H Array
32296183
Intra
PNLIPRP1 P54315 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
PNLIPRP1 P54315 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra
PNLIPRP1 P54315 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
PNLIPRP1 P54315 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra
PNLIPRP1 P54315 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 TSPAN8 Homo sapiens P19075
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 TSPAN8 Homo sapiens P19075
Y2H Array
32296183
Intra
PNLIPRP1 P54315 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
PNLIPRP1 P54315 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
PNLIPRP1 P54315 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
PNLIPRP1 P54315 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 NDUFAF1 Homo sapiens Q9Y375
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 NDUFAF1 Homo sapiens Q9Y375
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 NDUFAF1 Homo sapiens Q9Y375
Y2H Array
32296183
Intra
PNLIPRP1 P54315 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
PNLIPRP1 P54315 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
PNLIPRP1 P54315 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
PNLIPRP1 P54315 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PNLIPRP1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70991 PLRP1 Protein, Human (HEK293, His) AAH25784.1 (K18-C467) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Macular Degeneration, Age-Related, 10

  • ARMD10

  • Age Related Macular Degeneration 10

  • Macular Degeneration, Age-Related, Type 10
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10781 PNLIPRP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19849 Pnliprp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26347 Pnliprp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PNLIPRP1 VGNC VGNC:44746
Macaca mulatta PNLIPRP1 VGNC VGNC:76198
Rattus norvegicus PNLIPRP1 RGD RGD:620792
Mus musculus PNLIPRP1 MGD MGI:97723
Others PNLIPRP1 NCBI