SAT1 - spermidine/spermine N1-acetyltransferase 1 Gene

Also Known as SAT; DC21; KFSD; SSAT; KFSDX; SSAT-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6303

About SAT1

Cytogenetic location: Xp22.11 Genomic coordinates (GRCh38): X:23,783,173-23,786,210 (from NCBI)

This gene has 8 transcripts (splice variants), 293 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 336.5), thyroid (RPKM 226.9) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

SAT1 Products (1)

mRNA	Protein	Name
NM_002970.4	NP_002961.1	diamine acetyltransferase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables N-acetyltransferase activity	IDA IDA: Inferred from direct assay	15283699	GOA
enables diamine N-acetyltransferase activity	IDA IDA: Inferred from direct assay	15283699	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in angiogenesis	IEP IEP: Inferred from expression pattern	11866539	GOA
involved in polyamine biosynthetic process	IDA IDA: Inferred from direct assay	15283699	GOA
involved in spermidine acetylation	IDA IDA: Inferred from direct assay	15283699	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAT1 Protein Structure

Acetyltransf_1

0
100
171 a.a.

Protein Preferred Names	Protein Names
diamine acetyltransferase 1	diamine N-acetyltransferase 1

SAT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SAT1	P21673	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	32296183
Intra	SAT1	P21673	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	SAT1	P21673	FH	Homo sapiens	P07954	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	FH	Homo sapiens	P07954	Y2H Array	32296183
Intra	SAT1	P21673	CDC42EP1	Homo sapiens	Q00587-2	Validated Y2H	32296183
Intra	SAT1	P21673	CDC42EP1	Homo sapiens	Q00587-2	Y2H Array	32296183
Intra	SAT1	P21673	CDC42EP1	Homo sapiens	Q00587-2	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	SAT1	P21673	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	SAT1	P21673	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
Intra	SAT1	P21673	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
Intra	SAT1	P21673	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Array	32296183
Intra	SAT1	P21673	FAM86C1P	Homo sapiens	Q9NVL1-2	Validated Y2H	32296183
Intra	SAT1	P21673	FAM228A	Homo sapiens	Q86W67	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	FAM228A	Homo sapiens	Q86W67	Validated Y2H	32296183
Intra	SAT1	P21673	FAM228A	Homo sapiens	Q86W67	Y2H Array	32296183
Intra	SAT1	P21673	LYRM7	Homo sapiens	Q5U5X0	Validated Y2H	32296183
Intra	SAT1	P21673	LYRM7	Homo sapiens	Q5U5X0	Y2H Array	32296183
Intra	SAT1	P21673	LYRM7	Homo sapiens	Q5U5X0	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SAT1	P21673	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	SAT1	P21673	BHLHA9	Homo sapiens	Q7RTU4	Y2H Array	32296183
Intra	SAT1	P21673	BHLHA9	Homo sapiens	Q7RTU4	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	BHLHA9	Homo sapiens	Q7RTU4	Validated Y2H	32296183
Intra	SAT1	P21673	SPMIP10	Homo sapiens	Q6ZNM6	Validated Y2H	32296183
Intra	SAT1	P21673	SPMIP10	Homo sapiens	Q6ZNM6	Y2H Array	32296183
Intra	SAT1	P21673	SPMIP10	Homo sapiens	Q6ZNM6	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	CCDC148	Homo sapiens	Q8NFR7	Y2H Prey Pooling	25416956
Intra	SAT1	P21673	CCDC148	Homo sapiens	Q8NFR7	Y2H Array	19060904
Intra	SAT1	P21673	CCDC148	Homo sapiens	Q8NFR7	Y2H Pooling	19060904
Intra	SAT1	P21673	ABHD15	Homo sapiens	Q6UXT9	Validated Y2H	32296183
Intra	SAT1	P21673	MYPOP	Homo sapiens	Q86VE0	Validated Y2H	32296183
Intra	SAT1	P21673	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	SAT1	P21673	DDX39A	Homo sapiens	O00148	Validated Y2H	25416956
Intra	SAT1	P21673	DDX39A	Homo sapiens	O00148	Y2H Array	25416956
Intra	SAT1	P21673	EIF3D	Homo sapiens	O15371	Validated Y2H	25416956
Intra	SAT1	P21673	MRPL12	Homo sapiens	P52815	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	MRPL12	Homo sapiens	P52815	Y2H Array	32296183
Intra	SAT1	P21673	MRPL12	Homo sapiens	P52815	Validated Y2H	32296183
Intra	SAT1	P21673	PSMA1	Homo sapiens	P25786	Validated Y2H	32296183
Intra	SAT1	P21673	PSMA1	Homo sapiens	P25786	Y2H Array	32296183
Intra	SAT1	P21673	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	RPP25	Homo sapiens	Q9BUL9	Y2H Array	32296183
Intra	SAT1	P21673	RPP25	Homo sapiens	Q9BUL9	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	RPP25	Homo sapiens	Q9BUL9	Validated Y2H	32296183
Intra	SAT1	P21673	CASP7	Homo sapiens	P55210	Y2H Prey Pooling	25416956
Intra	SAT1	P21673	CASP7	Homo sapiens	P55210	Validated Y2H	25416956
Intra	SAT1	P21673	CASP7	Homo sapiens	P55210	Validated Y2H	32296183
Intra	SAT1	P21673	KCNA4	Homo sapiens	P22459	Validated Y2H	32296183
Intra	SAT1	P21673	KCNA4	Homo sapiens	P22459	Y2H Pooling	16169070
Intra	SAT1	P21673	KCNA4	Homo sapiens	P22459	Y2H Array	32296183
Intra	SAT1	P21673	KCNA4	Homo sapiens	P22459	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	TCF25	Homo sapiens	Q9BQ70	Y2H Prey Pooling	25416956
Intra	SAT1	P21673	RBM17	Homo sapiens	Q96I25	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	TCF25	Homo sapiens	Q9BQ70	Y2H Pooling	16189514
Intra	SAT1	P21673	RBM17	Homo sapiens	Q96I25	Y2H Array	31515488
Intra	SAT1	P21673	TCF25	Homo sapiens	Q9BQ70	Y2H Array	19060904
Intra	SAT1	P21673	TCF25	Homo sapiens	Q9BQ70	Y2H Array	31515488
Intra	SAT1	P21673	RBM17	Homo sapiens	Q96I25	Y2H Pooling	16189514
Intra	SAT1	P21673	TCF25	Homo sapiens	Q9BQ70	Validated Y2H	25416956
Intra	SAT1	P21673	RBM17	Homo sapiens	Q96I25	Validated Y2H	32296183
Intra	SAT1	P21673	RBM17	Homo sapiens	Q96I25	Y2H Array	25416956
Intra	SAT1	P21673	TCF25	Homo sapiens	Q9BQ70	Validated Y2H	32296183
Intra	SAT1	P21673	RBM17	Homo sapiens	Q96I25	Y2H Array	32296183
Intra	SAT1	P21673	RBM17	Homo sapiens	Q96I25	Y2H Prey Pooling	25416956
Intra	SAT1	P21673	MTA1	Homo sapiens	Q13330	Validated Y2H	25416956
Intra	SAT1	P21673	MTA1	Homo sapiens	Q13330	Y2H Array	25416956
Intra	SAT1	P21673	MTA1	Homo sapiens	Q13330	Y2H Prey Pooling	25416956
Intra	SAT1	P21673	COX6C	Homo sapiens	P09669	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	DIPK1B	Homo sapiens	Q5VUD6	Y2H Prey Pooling	25416956
Intra	SAT1	P21673	DIPK1B	Homo sapiens	Q5VUD6	Validated Y2H	25416956
Intra	SAT1	P21673	DIPK1B	Homo sapiens	Q5VUD6	Validated Y2H	32296183
Intra	SAT1	P21673	DIPK1B	Homo sapiens	Q5VUD6	Y2H Array	25416956
Intra	SAT1	P21673	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	SAT1	P21673	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	SAT1	P21673	LNX1	Homo sapiens	Q8TBB1	Y2H Pooling	16189514
Intra	SAT1	P21673	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	SAT1	P21673	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	SAT1	P21673	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	19060904
Intra	SAT1	P21673	NIF3L1	Homo sapiens	Q9GZT8	Y2H Pooling	19060904
Intra	SAT1	P21673	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	32296183
Intra	SAT1	P21673	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	32296183
Intra	SAT1	P21673	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	SAT1	P21673	C19orf25	Homo sapiens	Q9UFG5	Y2H Prey Pooling	25416956
Intra	SAT1	P21673	C19orf25	Homo sapiens	Q9UFG5	Y2H Array	25416956
Intra	SAT1	P21673	HOXB9	Homo sapiens	P17482	Validated Y2H	25416956
Intra	SAT1	P21673	HOXB9	Homo sapiens	P17482	Y2H Array	25416956
Intra	SAT1	P21673	TNNI1	Homo sapiens	P19237	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	TEAD4	Homo sapiens	Q15561	Validated Y2H	32296183
Intra	SAT1	P21673	TACO1	Homo sapiens	Q9BSH4	Y2H Pooling	16189514
Intra	SAT1	P21673	TACO1	Homo sapiens	Q9BSH4	Validated Y2H	32296183
Intra	SAT1	P21673	SAT2	Homo sapiens	Q96F10	Y2H Array	31515488
Intra	SAT1	P21673	SAT2	Homo sapiens	Q96F10	Y2H Pooling	16189514
Intra	SAT1	P21673	SAT2	Homo sapiens	Q96F10	Validated Y2H	32296183
Intra	SAT1	P21673	FAM156B	Homo sapiens	Q8NDB6	Y2H Prey Pooling	25416956
Intra	SAT1	P21673	FAM156B	Homo sapiens	Q8NDB6	Validated Y2H	25416956
Intra	SAT1	P21673	GAS2L2	Homo sapiens	Q8NHY3	Validated Y2H	32296183
Intra	SAT1	P21673	KHDC4	Homo sapiens	Q7Z7F0-4	Y2H Array	32296183
Intra	SAT1	P21673	KHDC4	Homo sapiens	Q7Z7F0-4	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	KHDC4	Homo sapiens	Q7Z7F0-4	Validated Y2H	32296183
Intra	SAT1	P21673	DMRT3	Homo sapiens	Q9NQL9	Y2H Prey Pooling	32296183
Intra	SAT1	P21673	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183
Intra	SAT1	P21673	DMRT3	Homo sapiens	Q9NQL9	Y2H Array	32296183
Intra	SAT1	P21673	DMRT3	Homo sapiens	Q9NQL9	Y2H Prey Pooling	25416956
Intra	SAT1	P21673	SNAI2	Homo sapiens	O43623	Y2H Array	25416956
Intra	SAT1	P21673	SNAI2	Homo sapiens	O43623	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Keratosis Follicularis Spinulosa Decalvans	Kfsd Keratosis Follicularis Spinulosa Decalvans Cum Ophiasi Keratosis Follicularis Spinulosa Decalvans, X-Linked Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant
Keratosis	Actinic Keratosis Hyperkeratosis
Tungiasis	Tunga Penetrans Infestation Chigger Flea S Penetrans Sarcopsylla Penetrans T Penetrans Tunga Penetrans Sand-Flea Infestation Jiggers Infestation Chigoe Infestation Jigger Disease
Syndromic X-Linked Intellectual Disability Snyder Type	Snyder-Robinson Syndrome Mental Retardation, X-Linked, Snyder-Robinson Type Spermine Synthase Deficiency Srs Snyder-Robinson Mental Retardation Syndrome X-Linked Intellectual Disability Snyder-Robinson Type Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type Snyder-Robinson X-Linked Mental Retardation Syndrome
Keratosis Pilaris Atrophicans	KPA Burnett Schwartz Berberian Syndrome
Acute Pancreatitis	Pancreatitis Pancreatitis, Acute Necrotizing Pancreatitis Nos Acute Pancreas Inflammation
Olmsted Syndrome, X-Linked	OLMSX Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-Linked Ppkmx X-Linked Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques X-Linked Olmsted Syndrome Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques, X-Linked
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS12455	SAT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13134	SLC26A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-175000	L14-8		/	Unkown
HY-N4161	Euparin	Inhibitor	99.0%	Unkown
HY-RS13217	SLC38A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17374	Sat1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23828	Sat1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26725	Slc38a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SAT1	RGD	RGD:1586174
Mus musculus	SAT1	MGD	MGI:98233
Macaca mulatta	SAT1	VGNC	VGNC:76973
Bos taurus	SAT1	VGNC	VGNC:34296
Canis familiaris	SAT1	VGNC	VGNC:82297
Others	SAT1	NCBI