CD69 - CD69 molecule Gene

Also Known as AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 969

About CD69

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:9,752,486-9,760,901 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 23 paralogues. Biased expression in bone marrow (RPKM 55.9), lymph node (RPKM 41.3) and 13 other tissues.

Summary

This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]

CD69 Products (1)

mRNA	Protein	Name
NM_001781.2	NP_001772.1	early activation antigen CD69

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	11101293	GOA
enables molecular sequestering activity	IDA IDA: Inferred from direct assay	37039481	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16525420	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	24752896	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of T cell migration	IDA IDA: Inferred from direct assay	37039481	GOA
involved in negative regulation of T-helper 17 cell lineage commitment	IDA IDA: Inferred from direct assay	24752896	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	37039481	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11101293	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD69 Protein Structure

Lectin_C

0
100
199 a.a.

Protein Preferred Names	Protein Names
early activation antigen CD69	C-type lectin domain family 2, member C

CD69 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CD69	Q07108	TMEM190	Homo sapiens	Q8WZ59	Validated Y2H	32296183
Intra	CD69	Q07108	TMEM190	Homo sapiens	Q8WZ59	Y2H Array	25416956
Intra	CD69	Q07108	NINJ2	Homo sapiens	Q9NZG7	Complementation	32296183
Intra	CD69	Q07108	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	CD69	Q07108	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	CD69	Q07108	SLC35B2	Homo sapiens	Q8TB61	Validated Y2H	32296183
Intra	CD69	Q07108	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	CD69	Q07108	BRICD5	Homo sapiens	Q6PL45-2	Validated Y2H	32296183
Intra	CD69	Q07108	S1PR1	Homo sapiens	P21453	Anti Bait CoIP	16525420
Intra	CD69	Q07108	S1PR1	Homo sapiens	P21453	Anti Tag CoIP	16525420
Intra	CD69	Q07108	EBP	Homo sapiens	Q15125	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD69 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P72713	CD69 Protein, Human (HEK293, His)	Q07108 (G64-K199)	≥ 95%, as determined by reducing SDS-PAGE.

CD69 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81373	CD69 Antibody (YA1118)	IHC-P	Human
HY-P81373A	CD69 Antibody (YA1118)(PBS only)	IHC-P	Human
HY-P84504	CD69 Antibody (YA4201)	IHC-P, FC, ELISA	Human
HY-P84504A	CD69 Antibody (YA4201)(PBS only)	IHC-P, FC, ELISA	Human
HY-P85004	CD69 Antibody (YA4696)	ELISA	Human

Related Diseases

Diseases	Alias
Coccidioidomycosis	Valley Fever Primary Extrapulmonary Coccidioidomycosis Coccidioides Immitis Infection Coccidiosis Coccidioides Infection Coccidioidomycosis, Unspecified San Joaquin Fever California Disease Desert Fever Desert Rheumatism San Joaquin Valley Fever Enteric Coccidiosis Primary Pulmonary Coccidioidomycosis Acute Coccidioidomycosis Posadas Wernicke Disease
Eosinophilic Pneumonia	Pneumonia, Eosinophilic Pulmonary Eosinophilia Asthmatic Pulmonary Eosinophilia Pneumonia Eosinophilic Simple Pulmonary Eosinophilia Eosinophilic Asthma
Milk Allergy	Milk Allergic Reaction Milk Hypersensitivity Allergy Milk
Intermediate Uveitis	Uveitis, Intermediate Chronic Cyclitis Peripheral Uveoretinitis Iu Uveitis Intermediate
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Peritonitis	Retractile Mesenteritis Sclerosing Mesenteritis Acute Generalized Peritonitis Primary Bacterial Peritonitis Idiopathic Sclerosing Mesenteritis Mesenteric Panniculitis Peritoneal Retractile Mesenteritis Liposclerotic Mesenteritis Mesenteric Fibromatosis Mesenteric Lipodystrophy Mesenteric Lipogranuloma Fibromatosis, Abdominal Peritoneum Inflammation Peritonitis Of Undetermined Cause Peritonitis Of Unspecified Cause Pelviperitonitis Pelvic Peritonitis, Nos Generalised Peritonitis Nos Abdominal Peritonitis Acute Idiopathic Peritonitis Acute Lesser Sac Peritonitis Acute Peritoneal Inflammation Diffuse Peritonitis Peritoneal Inflammation Acute Primary Peritonitis Pneumococcal Peritonitis
Uveitis
Synovitis
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Leishmaniasis	Post-Kala-Azar Dermal Leishmaniasis Post Kala-Azar Dermal Leishmaniasis Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis Cutaneous Leishmaniasis Kala-Azar Visceral Leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis, Visceral Leishmania Leishmania Infection Leishmaniosis
Hypereosinophilic Syndrome	Eosinophilia HES Eosinophilic Leukocytosis Hypereosinophilic Syndrome, Idiopathic Idiopathic Hypereosinophilic Syndrome Disseminated Eosinophilic Collagen Disease Eosinophilic Disorder Disorders With Increased Eosinophil Counts
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Psoriasis
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Carbapenem Allergy
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Primary Bacterial Infectious Disease
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P991900	LY3541860	Inhibitor	≥99.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-160229	ssRNA40 sodium		98.34%	Unkown
HY-155978A	RDN2150 TFA	Inhibitor	99.80%	Unkown
HY-108944	LYP-IN-1	Inhibitor	99.82%	Unkown
HY-155978	RDN2150	Inhibitor	/	Unkown
HY-18164	TASP0277308	Antagonist	99.00%	Unkown
HY-145373	BMS-986143	Inhibitor	/	Unkown
HY-145884	BTK-IN-8	Inhibitor	/	Unkown
HY-152201	BTK-IN-18	Inhibitor	/	Unkown
HY-159123	KHK-6	Inhibitor	/	Unkown
HY-181884	TLR9-IN-3		/	Unkown
HY-182503	GP515	Inhibitor	/	Unkown
HY-NP078A	Pisum Sativum Agglutinin (FITC)		/	Unkown
HY-RS02262	CD69 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17265	Cd69 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23719	Cd69 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990358	Anti-CD7 Antibody	Inhibitor	99.46%	Unkown
HY-P991479	Amtabafusp alfa		99%	Unkown
HY-P992375	HuMax-IL15	Inhibitor	/	Unkown
HY-P990265	Anti-Mouse CD69 Antibody (CD69.2.2)	Inhibitor	/	Unkown
HY-P990357	Anti-CD69 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD69	VGNC	VGNC:70776
Mus musculus	CD69	MGD	MGI:88343
Felis catus	CD69	VGNC	VGNC:83519
Rattus norvegicus	CD69	RGD	RGD:61318
Canis familiaris	CD69	VGNC	VGNC:38968
Bos taurus	CD69	VGNC	VGNC:27043
Macaca fascicularis	CD69	NCBI	NCBI:102141561
Others	CD69	NCBI