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Art. -Nr.: HY-148277

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KTX-612

KTX-612 is an orally active IRAK4 PROTAC degrader with a DC₅₀ value of 7 nM. KTX-612 can be used for the research of oncology.
(Pink: IRAK4 ligand (HY-150735); Blue: Cereblon ligand (HY-10984); Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2573298-14-1
Formel: C₄₆H₅₁F₃N₈O₆
Molecular Weight:868.94

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

KTX-612 Chemical Structure

CAS. Nr.: 2573298-14-1

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

KTX-612 is an orally active IRAK4 PROTAC degrader with a DC₅₀ value of 7 nM. KTX-612 can be used for the research of oncology^[1]. (Pink: IRAK4 ligand (HY-150735); Blue: Cereblon ligand (HY-10984); Black: linker).

IC₅₀ & Target

IRAK4

7 nM (DC₅₀)

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Alle IRAK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
OCI-Ly10	IC₅₀	8 nM Compound: 24	Antiproliferative activity against human OCI-Ly10 cells measured after 4 days by CellTiter-Glo Luminescent Cell Viability Assay Antiproliferative activity against human OCI-Ly10 cells measured after 4 days by CellTiter-Glo Luminescent Cell Viability Assay	[PMID: 38920289]

In Vitro

KTX-612 has activity for IRAK4 with a DC₅₀ value of 7 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KTX-612 (oral; 10 mg/kg) impacts oral absorption^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rat^[1]
Dosage:

10 mg/kg
Administration:

Oral
Result:

Rat PO PK (10 mg/kg) KTX-612

%F 1

AUC(μM*hr) 0.060

Chemical Information

CAS. Nr. 2573298-14-1
Molecular Weight 868.94
Formel C₄₆H₅₁F₃N₈O₆
SMILES

CC(C)(O)C1=CC2=NN(C=C2C=C1NC(C3=CC=CC(C(F)(F)F)=N3)=O)[C@H](CC4)CC[C@@H]4CN(CC5)CCC5(C6)CC6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Rat PO PK (10 mg/kg)	KTX-612
%F	1
AUC(μM*hr)	0.060

KTX-612

Alle PROTACs Isoform-spezifische Produkte anzeigen

Alle IRAK Isoform-spezifische Produkte anzeigen