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United States

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Art. -Nr.: HY-176067

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LO-4-25

LO-4-25 is a CUL4^DCAF16 based covalent PROTAC-like degrader. LO-4-25 induces degradation of the androgen receptor (AR) and androgen receptor truncation variant AR-V7. LO-4-25 covalently targets cysteine residues on CUL4^DCAF16 to mediate degradation of neo-substrates. LO-4-25 triggers proteasome-dependent degradation of target proteins via CUL4^DCAF16-mediated ubiquitination. LO-4-25 can be used for the research of androgen-independent prostate cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₂H₃₇ClN₆O₅S
Molecular Weight:653.19

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

LO-4-25 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

LO-4-25 (1-10 μM; 24 h) potently degrades both AR and AR-V7 in 22Rv1 cells in a CUL4_DCAF16-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

22Rv1 androgen-independent prostate cancer cells
Concentration:

1 μM, 10 μM
Incubation Time:

24 h
Result:

Induced robust degradation of both AR and AR-V7 in 22Rv1 cells.
Completely attenuated degradation of AR and AR-V7 in 22Rv1 cells with DCAF16 knockdown via siRNA transfection.

Chemical Information

Molecular Weight 653.19
Formel C₃₂H₃₇ClN₆O₅S
SMILES

O=C(NC1=CC(Cl)=CN=C1)/C=C/C(N2CCN(CC2)C(CCCCCOC3=CC=C(C=C3)C4=CSC(N5CCOCC5)=N4)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Orr LM, et al. DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders. ACS central science. 2025 Jul 23;11(7):1207-1217. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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