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Art. -Nr.: HY-174987

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mGluR1 activator-1

mGluR1 activator-1 is a stable Vitamin K (HY-B2172) analogue and a mGluR1 activator that can penetrate the blood-brain barrier. mGluR1 activator-1 exhibits strong transcriptional activation via steroid and xenobiotic receptor as well as retinoic acid receptor. mGluR1 activator-1 induces neuronal differentiation in mouse neural progenitor cells. mGluR1 activator-1 can be used for the study of neurodegenerative disease such as Alzheimer’s.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₇H₃₀O₄
Molecular Weight:418.52

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

mGluR1 activator-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

mGluR1

Alle mGluR Isoform-spezifische Produkte anzeigen :

In Vitro

mGluR1 activator-1 (Compound 7) (1-10 μM, 48 h) regulates transcriptional activity via SXR and RAR in neural stem cells^[1].
mGluR1 activator-1 (1 μM, 48 h) significantly increases the positive signal of Map2, indicating that it can effectively induce neural progenitor cells to differentiate into neurons^[1].
mGluR1 activator-1 (1-10 μM, 24 h) shows a concentration-dependent increase in cellular uptake in MG63 cells, and can be converted by the cells into a bioactive form Menaquinone-4 (MK-4) (HY-B2156)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

Neural progenitor cellsneural progenitor cells
Concentration:

1 μM
Incubation Time:

48 h
Result:

Observed a significant increase in Map2 mRNA expression.

In Vivo

mGluR1 activator-1 (Compound 7) (10 μmol/mL, p.o., single dose) enters the brain earlier than MK-4 and is converted to MK-4 by 24 h after administration in C57BL6J mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 418.52
Formel C₂₇H₃₀O₄
SMILES

O=C(/C(C)=C/C=C/C(C)=C/CC/C(C)=C/CC1=C(C(C2=C(C1=O)C=CC=C2)=O)C)OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hirota Y, et al. A New Class of Vitamin K Analogues Containing the Side Chain of Retinoic Acid Have Enhanced Activity for Inducing Neuronal Differentiation. ACS Chem Neurosci. 2025 Jul 3. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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