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MPTP

90 Cited Publications
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Based on 90 publication(s) in Google Scholar

MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a brain penetrant dopamine neurotoxin. MPTP can be used to induce Parkinson’s Disease model. MPTP, a precusor of MPP+, induces apoptosis.

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  • Reinheit: 99.78%
  • CAS. Nr.: 28289-54-5
  • Formel: C12H15N
  • Molecular Weight:173.25
  • Speicherung:

    RT, protect from light.

    In solvent   -80°C, 1 year , -20°C, 6 months
  • MPTP Chemical Structure
    MPTP Chemical Structure
  • Experimental Validation Results for MPTP
  • Experimental Validation Results for MPTP
  • Experimental Validation Results for MPTP
  • Experimental Validation Results for MPTP
CAS. Nr.: 28289-54-5
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  • MPTP Chemical Structure
    MPTP Chemical Structure
    1/16
  • 1/16

    MPTP purchased from MedChemExpress. Usage Cited in: Brain Res. 2019 Jul 15:1715:203-212. [Abstract]

    Customer Validation
     Immunofluorescence for TH. The intranigral Apelin-13 injection significantly inhibits MPTP-induced the neurodegeneration of dopaminergic neurons in the SNpc.

  • 1/16

    MPTP purchased from MedChemExpress. Usage Cited in: Pharmacol Biochem Behav. 2019 Feb:177:1-11. [Abstract]

    Customer Validation
     Effect of treatment with Rapamycin, trehalose, or their combination on autophagy activity measured by quantified immunoreactivity of LC3-II in the s. nigra. MPTP is administered at the dose of 20 mg/kg (i.p., daily) for 4 days to induce PD-like pathology.

  • 1/16

    MPTP purchased from MedChemExpress. Usage Cited in: Pharmacol Biochem Behav. 2019 Feb:177:1-11. [Abstract]

    Customer Validation
     Effect of treatment with Rapamycin, trehalose, or their combination on tyrosine hydroxylase (TH) expression in the striatum in MPTP-induced mouse model of Parkinson’s disease.

  • 1/16

    MPTP purchased from MedChemExpress. Usage Cited in: Brain Res. 2016 Jul 1:1642:546-552. [Abstract]

    Customer Validation
     RNA 5hmC decreases in a MPTP-induced Parkinson's disease mouse model. MPTP (i.p. 60 mg/kg) is injected to induce Parkinson's disease model in mice. At 24 h after last MPTP injection, open field test is performed. After behavioral tests, the hippocampus (Hipo), the substantia nigra (SN), the striatum (Str), and the cortex (Ctx) are collected and total RNA is extracted. Total 100 ng RNA is used for dot blot analysis to detect 5hmC abundance in RNA samples from different brain regions. Methylene bl

  • MPTP