P8RI
Based on 1 Customer Validation
P8RI (D-P8RI) is a biomimetic peptide of CD31 and a CD31 agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.49%
- CAS. Nr.: 2147724-76-1
- Formel: C51H77N13O9
- Molecular Weight:1016.24
-
Speicherung:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
Anti-Cardiovascular Disease Compound Library
HY-L046
-
Anti-Lung Cancer Compound Library
HY-L075
-
Anti-Pancreatic Cancer Compound Library
HY-L077
-
Angiogenesis-Related Compound Library
HY-L088
-
Peptide Library
HY-L105
-
Antidepressant Compound Library
HY-L108
-
Heterocyclic Compound Library
HY-L138
-
Antihypertensive Compound Library
HY-L145
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Protein Kinase Compound Library
HY-L196
-
High-Throughput Bioactive Compound Library
HY-L205
-
Immunology/Inflammation Compound Library
HY-L007
-
Protein Tyrosine Kinase Compound Library
HY-L016
-
Peptide Compound Library
HY-L105S
Alle VEGFR Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
P8RI (D-P8RI) was designed as a retro-inverso peptide with all-D-amino acids allowing to maintain bioactivity and to confer resistance towards plasma proteases[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Apo E -/- mice (male, 28-week-old) implanted with Ang II-releasing pumps (a model of experimental acute aortic dissection and intramural hematoma (ADIM))[3]
-
Dosage:2.5 mg/kg
-
Administration:Subcutaneous injection; daily from 7 to 28 (after the implantation of the osmotic pump delivering Ang II)
-
Result:Aneurysmal transformation was significantly reduced.
Chemical Information
-
CAS. Nr. 2147724-76-1
-
Appearance Solid
-
Molecular Weight 1016.24
-
Formel C51H77N13O9
-
Color White to off-white
-
Synonyms
D-P8RI
-
Sequence
d(Lys-Trp-Pro-Ala-Leu-Phe-Val-Arg)
-
Sequence Shortening
d(KWPALFVR)
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
H2O : ≥ 100 mg/mL (98.40 mM)
DMSO : 100 mg/mL (98.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (277 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Diaz-Rodriguez S, et al. Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo. Eur Heart J. 2021;42(18):1760-1769. [Content Brief]
[2]. Sannier A, et al. A CD31-Derived Peptide Prevents the Development of Antibody-Mediated Lesions in a Rat Model of Aortic Allograft. Transplant Proc. 2021;53(2):746-749. [Content Brief]
[3]. Andreata F, et al. Macrophage CD31 Signaling in Dissecting Aortic Aneurysm. J Am Coll Cardiol. 2018;72(1):45-57. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.9840 mL | 4.9201 mL | 9.8402 mL | 24.6005 mL |
| 5 mM | 0.1968 mL | 0.9840 mL | 1.9680 mL | 4.9201 mL | |
| 10 mM | 0.0984 mL | 0.4920 mL | 0.9840 mL | 2.4600 mL | |
| 15 mM | 0.0656 mL | 0.3280 mL | 0.6560 mL | 1.6400 mL | |
| 20 mM | 0.0492 mL | 0.2460 mL | 0.4920 mL | 1.2300 mL | |
| 25 mM | 0.0394 mL | 0.1968 mL | 0.3936 mL | 0.9840 mL | |
| 30 mM | 0.0328 mL | 0.1640 mL | 0.3280 mL | 0.8200 mL | |
| 40 mM | 0.0246 mL | 0.1230 mL | 0.2460 mL | 0.6150 mL | |
| 50 mM | 0.0197 mL | 0.0984 mL | 0.1968 mL | 0.4920 mL | |
| 60 mM | 0.0164 mL | 0.0820 mL | 0.1640 mL | 0.4100 mL | |
| 80 mM | 0.0123 mL | 0.0615 mL | 0.1230 mL | 0.3075 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
P8RI Related Classifications
HY-P3325 Related Classifications
Powered by Bioz