PF-04677490
PF-04677490 is a PDE1 inhibitor (IC50: 21 nM). PF-04677490 has IC50s of 21 nM, 83 nM, and 118 nM for PDE1B1, PDE1C, and PDE1A, respectively. PF-04677490 efficaciously inhibits cAMP- and cGMP-hydrolytic activity.
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- CAS. Nr.: 1628342-10-8
- Formel: C17H21N5O2
- Molecular Weight:327.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PDE1B 21 nM (IC50) |
PDE1C 83 nM (IC50) |
PDE1A 118 nM (IC50) |
Chemical Information
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CAS. Nr. 1628342-10-8
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Molecular Weight 327.38
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Formel C17H21N5O2
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SMILES
CC(CC1=NNC(C)=C1)NC2=C3C=CC(OC)=C(C3=NC=N2)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PF-04677490 Related Classifications
HY-120195 Related Classifications
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