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Phellopterin (Standard)

Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

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  • CAS. Nr.: 2543-94-4
  • Formel: C17H16O5
  • Molecular Weight:300.31
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Phellopterin (Standard) Chemical Structure
    Phellopterin (Standard) Chemical Structure
CAS. Nr.: 2543-94-4
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  • Phellopterin (Standard) Chemical Structure
    Phellopterin (Standard) Chemical Structure
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  • Phellopterin (Standard)